TGFβ family signaling: novel insights in development and disease

Advances in our understanding of the many levels of regulation of TGFβ and BMP signaling were reported at the recent FASEB Summer Conference entitled `The TGFβ Superfamily: Development and Disease', which was held in Carefree, Arizona, USA, on the northern edge of the Sonoran Desert. This conference was the fifth meeting in a biannual FASEB conference series and, as with the previous meetings, brought together biochemists, geneticists, developmental and tissue biologists interested in the inter-workings of TGFβ/BMP signaling pathways and in the consequences of these pathways going awry.

[1]  S. Newfeld,et al.  Informatics approaches to understanding TGFβ pathway regulation , 2009, Development.

[2]  David M. Umulis,et al.  The extracellular regulation of bone morphogenetic protein signaling , 2009, Development.

[3]  C. Heldin,et al.  The regulation of TGFβ signal transduction , 2009, Development.

[4]  M. Goumans,et al.  VEGF and inhibitors of TGFβ type-I receptor kinase synergistically promote blood-vessel formation by inducing α5-integrin expression , 2009, Journal of Cell Science.

[5]  R. Derynck,et al.  New regulatory mechanisms of TGF-beta receptor function. , 2009, Trends in cell biology.

[6]  R. Derynck,et al.  Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. , 2009, Developmental cell.

[7]  Samy Lamouille,et al.  TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. , 2009, Molecular cell.

[8]  Kai-ping Yan,et al.  Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas , 2009, PLoS genetics.

[9]  V. Corces,et al.  CTCF: Master Weaver of the Genome , 2009, Cell.

[10]  J. Parker,et al.  Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. , 2009, The Journal of clinical investigation.

[11]  O. Shimmi,et al.  The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites , 2009, Proceedings of the National Academy of Sciences.

[12]  Shawn C. Little,et al.  BMP heterodimers assemble hetero-type I receptor complexes that pattern the DV axis , 2009, Nature Cell Biology.

[13]  C. Hill,et al.  Tgf-beta superfamily signaling in embryonic development and homeostasis. , 2009, Developmental cell.

[14]  R. Derynck,et al.  TGFβ‐stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro‐migratory TGFβ switch , 2009, The EMBO journal.

[15]  Leonardo Morsut,et al.  FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination , 2009, Cell.

[16]  Q. Nie,et al.  Cell Lineages and the Logic of Proliferative Control , 2009, PLoS biology.

[17]  Li Yang,et al.  Transforming Growth Factor B : Tumor Suppressor or Promoter ? Are Host Immune Cells the Answer ? , 2008 .

[18]  Hilary L. Ashe,et al.  Type IV collagens regulate BMP signalling in Drosophila , 2008, Nature.

[19]  J. Massagué,et al.  TGFβ in Cancer , 2008, Cell.

[20]  M. Yaffe,et al.  TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal , 2008, Nature Cell Biology.

[21]  Paul A. Bates,et al.  Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system , 2008, Proceedings of the National Academy of Sciences.

[22]  田中 千夏 Long-range action of Nodal requires interaction with GDF1 , 2008 .

[23]  Y. Saijoh,et al.  Long-range action of Nodal requires interaction with GDF1. , 2007, Genes & development.

[24]  Y. Henis,et al.  A unique element in the cytoplasmic tail of the type II transforming growth factor-beta receptor controls basolateral delivery. , 2007, Molecular biology of the cell.

[25]  Y. Ip,et al.  Msk is required for nuclear import of TGF-β/BMP-activated Smads , 2007, The Journal of cell biology.

[26]  N. Minato,et al.  SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion , 2007, Nature Genetics.

[27]  D. Constam,et al.  The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. , 2006, Developmental cell.

[28]  Shawn C. Little,et al.  Extracellular modulation of BMP activity in patterning the dorsoventral axis. , 2006, Birth defects research. Part C, Embryo today : reviews.

[29]  Wei He,et al.  Hematopoiesis Controlled by Distinct TIF1γ and Smad4 Branches of the TGFβ Pathway , 2006, Cell.

[30]  A. Balmain,et al.  Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Olga Varlamova,et al.  Erratum: A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis (Proceedings of the National Academy of Sciences of the United States of America (November 8, 2005) 102, 45 (16426-16431) DOI: 10.1073/pnas.0508448102) , 2006 .

[32]  R. Derynck,et al.  SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS , 2005 .

[33]  H. Othmer,et al.  Facilitated Transport of a Dpp/Scw Heterodimer by Sog/Tsg Leads to Robust Patterning of the Drosophila Blastoderm Embryo , 2005, Cell.

[34]  D. Rifkin Latent Transforming Growth Factor-β (TGF-β) Binding Proteins: Orchestrators of TGF-β Availability* , 2005, Journal of Biological Chemistry.

[35]  J. Wrana,et al.  Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP‐dependent dendritogenesis , 2004, The EMBO journal.

[36]  G. Thomas,et al.  Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4. , 2004, Molecular biology of the cell.

[37]  E. D. De Robertis,et al.  Dorsal-ventral patterning and neural induction in Xenopus embryos. , 2004, Annual review of cell and developmental biology.

[38]  M. Goumans,et al.  Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors , 2002, The EMBO journal.

[39]  T. Nakayama,et al.  The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor. , 2001, Genes & development.

[40]  Xiang-Xi Xu,et al.  The adaptor molecule Disabled‐2 links the transforming growth factor β receptors to the Smad pathway , 2001, The EMBO journal.

[41]  S. Dixit Type-IV collagens. Isolation and characterization of two structurally distinct collagen chains from bovine kidney cortices. , 1980, European journal of biochemistry.

[42]  M. Matzuk,et al.  Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose. , 2009, Molecular endocrinology.

[43]  Leonardo Morsut,et al.  FAM / USP 9 x , a Deubiquitinating Enzyme Essential for TGF b Signaling , Controls Smad 4 Monoubiquitination , 2009 .

[44]  Samy Lamouille,et al.  TACE-Mediated Ectodomain Shedding of the Type I TGF-b Receptor Downregulates TGF-b Signaling , 2009 .

[45]  R. Derynck,et al.  TGF- and the TGF- Family , 2008 .

[46]  David M. Umulis,et al.  Robustness of embryonic spatial patterning in Drosophila melanogaster. , 2008, Current topics in developmental biology.

[47]  A. Hata,et al.  SMAD proteins control DROSHA-mediated microRNA maturation , 2008, Nature.

[48]  S. Ross,et al.  How the Smads regulate transcription. , 2008, The international journal of biochemistry & cell biology.

[49]  R. Derynck,et al.  The TGF-β Family , 2008 .

[50]  In Ho Choi,et al.  A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva , 2006, Nature Genetics.

[51]  V. Rosen,et al.  Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo. , 1996, Growth factors.

[52]  R. Randall,et al.  Transforming Growth Factor (cid:2) -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth (cid:1) † , 2008 .