A Map of Alzheimer's Disease–Signaling Pathways: A Hope for Drug Target Discovery

Alzheimer's disease (AD) is a complex neurodegenerative condition, and its drug therapy is challenging. To inform AD drug discovery, we developed the “AlzPathway,” a prototype of a comprehensive map of AD‐related signaling pathways, from information obtained through studies in the public domain. The AlzPathway provides an integrated platform for systems analyses of AD‐signaling pathways and networks.

[1]  D. Selkoe Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[2]  N. Kikuchi,et al.  CellDesigner 3.5: A Versatile Modeling Tool for Biochemical Networks , 2008, Proceedings of the IEEE.

[3]  Samik Ghosh,et al.  Payao: a community platform for SBML pathway model curation , 2010, Bioinform..

[4]  Anne Corbett,et al.  Alzheimer's disease , 2011, The Lancet.

[5]  H. Kitano A robustness-based approach to systems-oriented drug design , 2007, Nature Reviews Drug Discovery.

[6]  Samik Ghosh,et al.  AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease , 2012, BMC Systems Biology.