Conversion of titania (TiO2) into conductive titanium (Ti) nanotube arrays for combined drug-delivery and electrical stimulation therapy.

The conversion of titania (TiO2) nanotubes into titanium (Ti), while preserving their nanotubular structures, is demonstrated. Their application as bone implants and electrodes for combined local drug delivery and electrical stimulation therapy is proposed.

[1]  Dusan Losic,et al.  Nano-engineered titanium for enhanced bone therapy , 2013, Optics & Photonics - NanoScience + Engineering.

[2]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[3]  K. Gulati,et al.  Optimizing anodization conditions for the growth of titania nanotubes on curved surfaces , 2015 .

[4]  Ye Cai,et al.  Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas , 2007, Nature.

[5]  Dusan Losic,et al.  Drug-releasing implants: current progress, challenges and perspectives. , 2014, Journal of materials chemistry. B.

[6]  C. Rubin,et al.  Effects of electromagnetic fields in experimental fracture repair. , 1998, Clinical orthopaedics and related research.

[7]  Dusan Losic,et al.  Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays. , 2012, Therapeutic delivery.

[8]  Thomas J Webster,et al.  Decreased Staphylococcus aureus biofilm growth on anodized nanotubular titanium and the effect of electrical stimulation. , 2011, Acta biomaterialia.

[9]  T. Webster,et al.  The effect of biphasic electrical stimulation on osteoblast function at anodized nanotubular titanium surfaces. , 2010, Biomaterials.

[10]  Hongwei Ni,et al.  Antibacterial nano-structured titania coating incorporated with silver nanoparticles. , 2011, Biomaterials.

[11]  D. Losic,et al.  Luminescent Silicon Diatom Replicas: Self‐Reporting and Degradable Drug Carriers with Biologically Derived Shape for Sustained Delivery of Therapeutics , 2015 .

[12]  Jonas Addai-Mensah,et al.  Magnetic-responsive delivery of drug-carriers using titania nanotube arrays , 2012 .

[13]  Deborah McK Ciombor,et al.  Treatment of nonunions with electric and electromagnetic fields. , 2004, Clinical orthopaedics and related research.

[14]  Tejal A Desai,et al.  Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes. , 2007, Biomaterials.

[15]  Paul A. Glazer,et al.  Electrical stimulation therapies for spinal fusions: current concepts , 2006, European Spine Journal.

[16]  Dusan Losic,et al.  Non-eroding drug-releasing implants with ordered nanoporous and nanotubular structures: concepts for controlling drug release. , 2014, Biomaterials science.

[17]  Patrik Schmuki,et al.  TiO2 nanotubes: synthesis and applications. , 2011, Angewandte Chemie.

[18]  Martin J. Sweetman,et al.  Silicon diatom frustules as nanostructured photoelectrodes. , 2014, Chemical communications.

[19]  J. Addai-Mensah,et al.  A multi-drug delivery system with sequential release using titania nanotube arrays. , 2012, Chemical communications.

[20]  Dusan Losic,et al.  Nanoengineered drug-releasing Ti wires as an alternative for local delivery of chemotherapeutics in the brain , 2012, International journal of nanomedicine.

[21]  T. Okuma.  Magnesium and bone strength. , 2001, Nutrition.

[22]  K. Popat,et al.  Titania nanotube arrays as interfaces for neural prostheses. , 2015, Materials science & engineering. C, Materials for biological applications.

[23]  Thomas J Webster,et al.  Diameter of titanium nanotubes influences anti-bacterial efficacy , 2011, Nanotechnology.

[24]  Peter Pivonka,et al.  Characterization of drug-release kinetics in trabecular bone from titania nanotube implants , 2012, International journal of nanomedicine.

[25]  Dusan Losic,et al.  Titania nanotube arrays for local drug delivery: recent advances and perspectives , 2015, Expert opinion on drug delivery.

[26]  C. R. Howlett,et al.  The Effect of Magnesium Ions on Bone Bonding to Hydroxyapatite Coating on Titanium Alloy Implants , 2003 .

[27]  Tejal A Desai,et al.  Influence of engineered titania nanotubular surfaces on bone cells. , 2007, Biomaterials.

[28]  Thomas J Webster,et al.  Multiwalled carbon nanotubes enhance electrochemical properties of titanium to determine in situ bone formation , 2008, Nanotechnology.

[29]  Dusan Losic,et al.  Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection , 2011, Nanoscale research letters.

[30]  Nicole R. Luke-Marshall,et al.  Cathodic voltage-controlled electrical stimulation of titanium implants as treatment for methicillin-resistant Staphylococcus aureus periprosthetic infections. , 2015, Biomaterials.