Dietary habits and mortality in 11 000 vegetarians and health conscious people: results of a 17 year follow up

Abstract Objective: To investigate the association of dietary habits with mortality in a cohort of vegetarians and other health conscious people. Design: Observational study. Setting: United Kingdom. Subjects: 4336 men and 6435 women recruited through health food shops, vegetarian societies, and magazines. Main outcome measures: Mortality ratios for vegetarianism and for daily versus less than daily consumption of wholemeal bread, bran cereals, nuts or dried fruit, fresh fruit, and raw salad in relation to all cause mortality and mortality from ischaemic heart disease, cerebrovascular disease, all malignant neoplasms, lung cancer, colorectal cancer, and breast cancer. Results: 2064 (19%) subjects smoked, 4627 (43%) were vegetarian, 6699 (62%) ate wholemeal bread daily, 2948 (27%) ate bran cereals daily, 4091 (38%) ate nuts or dried fruit daily, 8304 (77%) ate fresh fruit daily, and 4105 (38%) ate raw salad daily. After a mean of 16.8 years follow up there were 1343 deaths before age 80. Overall the cohort had a mortality about half that of the general population. Within the cohort, daily consumption of fresh fruit was associated with significantly reduced mortality from ischaemic heart disease (rate ratio adjusted for smoking 0.76 (95% confidence interval 0.60 to 0.97)), cerebrovascular disease (0.68 (0.47 to 0.98)), and for all causes combined (0.79 (0.70 to 0.90)). Conclusions: In this cohort of health conscious individuals, daily consumption of fresh fruit is associated with a reduced mortality from ischaemic heart disease, cerebrovascular disease, and all causes combined. Key messages This study examined dietary factors associated with mortality among 11 000 health conscious people followed for an average of 17 years. After smoking was adjusted for, daily consumption of fresh fruit was associated with a 24% reduction in mortality from ischaemic heart disease, a 32% reduction in mortality from cerebrovascular disease, and a 21% reduction in all cause mortality compared with less frequent consumption.

[1]  D. Burkitt,et al.  Some diseases characteristic of modern Western civilization. , 1973, British medical journal.

[2]  L. Garfinkel,et al.  Mortality among California Seventh-Day Adventists for selected cancer sites. , 1980, Journal of the National Cancer Institute.

[3]  M. Burr,et al.  Plasma cholesterol and blood pressure in vegetarians. , 1981, Journal of human nutrition.

[4]  M. Burr,et al.  Vegetarianism, dietary fiber, and mortality. , 1982, The American journal of clinical nutrition.

[5]  R. Acheson,et al.  DOES CONSUMPTION OF FRUIT AND VEGETABLES PROTECT AGAINST STROKE? , 1983, The Lancet.

[6]  D. Snowdon,et al.  Meat consumption and fatal ischemic heart disease. , 1984, Preventive medicine.

[7]  D. Snowdon,et al.  Association between reported diet and all-cause mortality. Twenty-one-year follow-up on 27,530 adult Seventh-Day Adventists. , 1984, American journal of epidemiology.

[8]  Kay-Tee Khaw,et al.  Dietary Potassium and Stroke-Associated Mortality - A 12 Year Prospective Population Based Study , 1986 .

[9]  J. Annegers,et al.  Animal product consumption and subsequent fatal breast cancer risk among Seventh-day Adventists. , 1988, American journal of epidemiology.

[10]  B. Butland,et al.  Heart disease in British vegetarians. , 1988, The American journal of clinical nutrition.

[11]  G. Fraser,et al.  Dietary habits and breast cancer incidence among seventh‐day adventists , 1989, Cancer.

[12]  C. la Vecchia,et al.  Association between certain foods and risk of acute myocardial infarction in women. , 1990, BMJ.

[13]  P. Allhoff,et al.  The Western Electric Study , 1991 .

[14]  J. Chang-Claude,et al.  Mortality Pattern of German Vegetarians after 11 Years of Follow-up , 1992, Epidemiology.

[15]  J. Enstrom,et al.  Vitamin C Intake and Mortality among a Sample of the United States Population , 1992, Epidemiology.

[16]  G. Block,et al.  Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. , 1992, Nutrition and cancer.

[17]  E. Feskens,et al.  Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study , 1993, The Lancet.

[18]  A. Reunanen,et al.  Antioxidant vitamin intake and coronary mortality in a longitudinal population study. , 1994, American journal of epidemiology.

[19]  B. Ganesh,et al.  Role of reproductive factors in breast cancer in a low-risk area: a case-control study. , 1994, British Journal of Cancer.

[20]  M. Law,et al.  Systematic underestimation of association between serum cholesterol concentration and ischaemic heart disease in observational studies: data from the BUPA study , 1994, BMJ.

[21]  K. McPherson,et al.  Risk of death from cancer and ischaemic heart disease in meat and non-meat eaters , 1994, BMJ.

[22]  C. Cooper,et al.  Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people , 1995, BMJ.

[23]  J. Stamler,et al.  Dietary vitamin C and beta-carotene and risk of death in middle-aged men. The Western Electric Study. , 1995, American journal of epidemiology.

[24]  J. Potter Risk factors for colon neoplasia--epidemiology and biology. , 1995, European journal of cancer.

[25]  P. Wolf,et al.  Protective effect of fruits and vegetables on development of stroke in men. , 1995, JAMA.

[26]  G A Colditz,et al.  A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly. , 1995, Annals of epidemiology.