Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study.

[1]  E. Achten,et al.  1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique , 2010, Magnetic Resonance Materials in Physics, Biology and Medicine.

[2]  Ludovico Minati,et al.  Quantitation of normal metabolite concentrations in six brain regions by in-vivo 1H-MR spectroscopy , 2010, Journal of medical physics.

[3]  Peter Mattsson,et al.  Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1h magnetic resonance spectroscopy (MRS) study , 2010, Acta radiologica.

[4]  Kuncheng Li,et al.  Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and alzheimer disease , 2009, Acta radiologica.

[5]  Linda Chang,et al.  Effects of age and sex on brain glutamate and other metabolites. , 2009, Magnetic resonance imaging.

[6]  E Moser,et al.  Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy. , 2008, European journal of radiology.

[7]  Linda Chang,et al.  Regional variations and the effects of age and gender on glutamate concentrations in the human brain. , 2008, Magnetic resonance imaging.

[8]  R. Morris,et al.  The relationship between white matter brain metabolites and cognition in normal aging: The GENIE study , 2007, Brain Research.

[9]  N. Giusto,et al.  Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system , 1992, Lipids.

[10]  G. Rouser,et al.  Curvilinear regression course of human brain lipid composition changes with age , 1968, Lipids.

[11]  B. Barbiroli,et al.  Assessment of glutamate and glutamine contribution to in vivo N‐acetylaspartate quantification in human brain by 1H‐magnetic resonance spectroscopy , 2005, Magnetic resonance in medicine.

[12]  Chris Boesch,et al.  Integrated data acquisition and processing to determine metabolite contents, relaxation times, and macromolecule baseline in single examinations of individual subjects , 2005, Magnetic resonance in medicine.

[13]  Hans-Jochen Heinze,et al.  Quantitative MR analyses of the hippocampus: Unspecific metabolic changes in aging , 2004, Journal of Neurology.

[14]  K. R. Ridderinkhof,et al.  Age-related changes in the efficiency of cognitive processing across the life span. , 2004, Acta psychologica.

[15]  R. Sutherland,et al.  The aging hippocampus: cognitive, biochemical and structural findings. , 2003, Cerebral cortex.

[16]  Matthijs Oudkerk,et al.  Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. , 2003, Radiology.

[17]  Stephen K Fisher,et al.  Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance , 2002, Journal of neurochemistry.

[18]  Derek K. Jones,et al.  Evidence for cortical “disconnection” as a mechanism of age-related cognitive decline , 2001, Neurology.

[19]  N Roberts,et al.  A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. , 2001, Cerebral cortex.

[20]  H. Nishitani,et al.  Multivariate analysis of regional metabolic differences in normal ageing on localised quantitative proton MR spectroscopy , 2001, Neuroradiology.

[21]  M W Weiner,et al.  Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging , 2001, Magnetic resonance in medicine.

[22]  A. Apkarian,et al.  Aging alters regional multichemical profile of the human brain: an in vivo1H‐MRS study of young versus middle‐aged subjects , 2001, Journal of neurochemistry.

[23]  T Horinouchi,et al.  Development and aging of the cerebrum: assessment with proton MR spectroscopy. , 2001, AJNR. American journal of neuroradiology.

[24]  J J Mallet,et al.  Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study. , 2001, AJNR. American journal of neuroradiology.

[25]  E G Tangalos,et al.  Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease , 2000, Neurology.

[26]  G J Barker,et al.  A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis. , 2000, Magnetic resonance imaging.

[27]  J R Griffiths,et al.  Aging of the adult human brain: In vivo quantitation of metabolite content with proton magnetic resonance spectroscopy , 1999, Journal of magnetic resonance imaging : JMRI.

[28]  K. Berman,et al.  Context-dependent, neural system-specific neurophysiological concomitants of ageing: mapping PET correlates during cognitive activation. , 1999, Brain : a journal of neurology.

[29]  Gioacchino Tedeschi,et al.  MR image segmentation and tissue metabolite contrast in 1H spectroscopic imaging of normal and aging brain , 1999, Magnetic resonance in medicine.

[30]  K O Lim,et al.  In vivo spectroscopic quantification of the N‐acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: Effects of normal aging , 1999, Magnetic resonance in medicine.

[31]  J. Frahm,et al.  Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS , 1998, Magnetic resonance in medicine.

[32]  G. Fein,et al.  Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease , 1997, Neurology.

[33]  D. Graham,et al.  Aging‐associated Changes in Human Brain , 1997, Journal of neuropathology and experimental neurology.

[34]  P. Landfield,et al.  Brain Creatine Kinase with Aging in F-344 Rats: Analysis by Saturation Transfer Magnetic Resonance Spectroscopy , 1997, Neurobiology of Aging.

[35]  L. Svennerholm,et al.  Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes , 1997, Acta Neuropathologica.

[36]  K. Takenouchi,et al.  Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects , 1997 .

[37]  K. Lim,et al.  Estimating NAA in cortical gray matter with applications for measuring changes due to aging , 1997, Magnetic resonance in medicine.

[38]  I. Wilkinson,et al.  Cerebral volumes and spectroscopic proton metabolites on MR: is sex important? , 1997, Magnetic resonance imaging.

[39]  D J Jenden,et al.  In vivo proton magnetic resonance spectroscopy of the normal aging human brain. , 1996, Life sciences.

[40]  A. Alavi,et al.  Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[41]  B D Ross,et al.  Absolute Quantitation of Water and Metabolites in the Human Brain. I. Compartments and Water , 1993 .

[42]  O Almkvist,et al.  White-matter hyperintensity and neuropsychological functions in dementia and healthy aging. , 1992, Archives of neurology.

[43]  William H. Oldendorf,et al.  N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain , 1989, Neuroscience & Biobehavioral Reviews.

[44]  R. DeTeresa,et al.  Neocortical cell counts in normal human adult aging , 1987, Annals of neurology.

[45]  P. Sastry,et al.  Lipids of nervous tissue: composition and metabolism. , 1985, Progress in lipid research.

[46]  H. Tallan.  Studies on the distribution of N-acetyl-L-aspartic acid in brain. , 1957, The Journal of biological chemistry.