World Journal of Surgical Oncology Aberrant Nuclear Localization of Β-catenin without Genetic Alterations in Β-catenin or Axin Genes in Esophageal Cancer

Background: β-catenin is a multifunctional protein involved in two apparently independent processes: cell-cell adhesion and signal transduction. β-catenin is involved in Wnt signaling pathway that regulates cellular differentiation and proliferation. In this study, we investigated the expression pattern of β-catenin and cyclin D1 using immunohistochemistry and searched for mutations in exon 3 of the β-catenin gene and Axin gene in esophageal squamous cell carcinoma.

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