Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products
暂无分享,去创建一个
T. Egan | G. Bringmann | L. Birkholtz | P. Moyo | V. Maharaj | Janette Reader | Mariëtte E. van der Watt | A. C. C. de Sousa | W. Shamburger
[1] L. Birkholtz,et al. Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites , 2020, Scientific Reports.
[2] David M. Shackleford,et al. An in vitro toolbox to accelerate anti-malarial drug discovery and development , 2020, Malaria Journal.
[3] D. Feineis,et al. Dimeric naphthylisoquinoline alkaloids: polyketide-derived axially chiral bioactive quateraryls. , 2019, Natural product reports.
[4] H. Wajant,et al. A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus. , 2019, Journal of natural products.
[5] Suttipat Srisutham,et al. An online mapping database of molecular markers of drug resistance in Plasmodium falciparum: the ACT Partner Drug Molecular Surveyor , 2019, Malaria Journal.
[6] D. Taramelli,et al. Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages , 2018, Antimicrobial Agents and Chemotherapy.
[7] Gonzalo Colmenarejo,et al. Predicting transmission blocking potential of anti-malarial compounds in the Mosquito Feeding Assay using Plasmodium falciparum Male Gamete Inhibition Assay , 2018, Scientific Reports.
[8] K. Chibale,et al. Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials , 2018, The Journal of antimicrobial chemotherapy.
[9] K. Haldar,et al. Drug resistance in Plasmodium , 2018, Nature Reviews Microbiology.
[10] M. Murata,et al. Stable C-N axial chirality in 1-aryluracil scaffold and differences in in vitro metabolic clearance between atropisomers of PDE4 inhibitor. , 2017, Bioorganic & medicinal chemistry.
[11] D. Feineis,et al. Antiplasmodial Ealapasamines A-C,‘Mixed’ Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis , 2017, Scientific Reports.
[12] Z. Gu,et al. Discovery and Assessment of Atropisomers of (±)-Lesinurad. , 2017, ACS medicinal chemistry letters.
[13] J. Burrows,et al. New developments in anti-malarial target candidate and product profiles , 2017, Malaria Journal.
[14] J. Eloff,et al. In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species. , 2016, Journal of ethnopharmacology.
[15] G. Mohamed,et al. Naphthylisoquinoline alkaloids potential drug leads. , 2015, Fitoterapia.
[16] D. Mancama,et al. Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination , 2015, Malaria Journal.
[17] R. Sinden,et al. A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs , 2014, Antimicrobial Agents and Chemotherapy.
[18] S. Abay. Blocking malaria transmission to Anopheles mosquitoes using artemisinin derivatives and primaquine: a systematic review and meta-analysis , 2013, Parasites & Vectors.
[19] T. Kupfer,et al. Jozimine A2: the first dimeric Dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity. , 2013, Chemistry.
[20] E. Winzeler,et al. The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites , 2012, PLoS medicine.
[21] Shiv k. Sharma,et al. Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities. , 2011, Journal of medicinal chemistry.
[22] D. Wright,et al. Use of the NP-40 Detergent-Mediated Assay in Discovery of Inhibitors of β-Hematin Crystallization , 2011, Antimicrobial Agents and Chemotherapy.
[23] K. Baumann,et al. QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. , 2010, European journal of medicinal chemistry.
[24] D. Wright,et al. Lipophilic Mediated Assays for β-Hematin Inhibitors , 2010 .
[25] L. Di,et al. Chapter 25 – Solubility Methods , 2008 .
[26] G. Bringmann,et al. The Novel Antimalarial Compound Dioncophylline C Forms a Complex with Heme in Solution , 2007, ChemMedChem.
[27] Inga Kajahn,et al. Ancistrocladinium A and B, the First N,C-Coupled Naphthyldihydroisoquinoline Alkaloids, from a Congolese Ancistrocladus Species¶ , 2006 .
[28] Inga Kajahn,et al. Activities of Naphthylisoquinoline Alkaloids and Synthetic Analogs against Leishmania major , 2006, Antimicrobial Agents and Chemotherapy.
[29] T. Egan,et al. A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds. , 2005, Analytical biochemistry.
[30] D. Huryn,et al. Experimental design on single-time-point high-throughput microsomal stability assay. , 2004, Journal of pharmaceutical sciences.
[31] G. Bringmann,et al. Habropetaline A, an antimalarial naphthylisoquinoline alkaloid from Triphyophyllum peltatum. , 2003, Phytochemistry.
[32] G. Bringmann,et al. Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis. , 2000, Journal of natural products.
[33] R. Obach,et al. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[34] J. Holenz,et al. Naphthylisoquinoline alkaloids against malaria: evaluation of the curative potentials of dioncophylline C and dioncopeltine A against Plasmodium berghei in vivo , 1997, Antimicrobial agents and chemotherapy.
[35] Gerhard Bringmann,et al. In vitro inhibition of liver forms of the rodent malaria parasite Plasmodium berghei by naphthylisoquinoline alkaloids – structure-activity relationships of dioncophyllines A and C and ancistrocladine , 1997, Parasitology Research.
[36] J. Holenz,et al. Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceae and Ancistrocladaceae species. , 1997, International journal for parasitology.
[37] J. Holenz,et al. Naphthylisoquinoline alkaloids exhibit strong growth-inhibiting activities against Plasmodium falciparum and P. berghei in vitro--structure-activity relationships of dioncophylline C. , 1996, Annals of tropical medicine and parasitology.
[38] G. Bringmann,et al. Activities of extracts and naphthylisoquinoline alkaloids from Triphyophyllum peltatum, Ancistrocladus abbreviatus and Ancistrocladus barteri against Plasmodium berghei (Anka strain) in vitro. , 1995, Journal of ethnopharmacology.
[39] G. Bringmann,et al. Chapter 4 The Naphthylisoquinoline Alkaloids , 1995 .
[40] G. Bringmann,et al. Activity of extracts and naphthylisoquinoline alkaloids from Triphyophyllum peltatum, Ancistrocladus abbreviatus and A. Barteri against Plasmodium falciparum in vitro , 1994 .