Investigation of multi-trait associations using pathway-based analysis of GWAS summary statistics

[1]  J. Hardy,et al.  Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis , 2018, Proceedings of the National Academy of Sciences.

[2]  Zhongming Zhao,et al.  An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies , 2018, Genome Medicine.

[3]  S C DeShields,et al.  Comparison of osteoporosis in US adults with type 1 and type 2 diabetes mellitus , 2018, Journal of Endocrinological Investigation.

[4]  Liting Guo,et al.  Effects of serum 25-hydroxyvitaminD level on decreased bone mineral density at femoral neck and total hip in Chinese type 2 diabetes , 2017, PloS one.

[5]  A. Lyra,et al.  Bone mineral density and inflammatory bowel disease severity , 2017, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[6]  M. Rietschel,et al.  Associations between SNPs and immune-related circulating proteins in schizophrenia , 2017, Scientific Reports.

[7]  G. Carter,et al.  Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease. , 2017, Cell reports.

[8]  J. Snell-Bergeon,et al.  Bone mineral density at femoral neck and lumbar spine in adults with type 1 diabetes: a meta-analysis and review of the literature , 2017, Osteoporosis International.

[9]  Christopher S. Poultney,et al.  Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia , 2017, Molecular Autism.

[10]  Alexander Gusev,et al.  Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits. , 2017, American journal of human genetics.

[11]  Helen E. Parkinson,et al.  The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog) , 2016, Nucleic Acids Res..

[12]  A. Price,et al.  Dissecting the genetics of complex traits using summary association statistics , 2016, Nature Reviews Genetics.

[13]  Adam R. Johnson,et al.  Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity , 2016, Science Translational Medicine.

[14]  K. Kahl,et al.  Bone density and depressive disorder: a meta‐analysis , 2016, Brain and behavior.

[15]  R. Djidjik,et al.  Association study of single nucleotide polymorphisms of IL23R and IL17 in rheumatoid arthritis in the Algerian population. , 2016, Acta reumatologica portuguesa.

[16]  Daniel Marbach,et al.  Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics , 2016, PLoS Comput. Biol..

[17]  Joseph K. Pickrell,et al.  Detection and interpretation of shared genetic influences on 42 human traits , 2015, Nature Genetics.

[18]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[19]  Z. Zhai,et al.  Autoimmune risk loci of IL12RB2, IKZF1, XKR6, TMEM39A and CSK in Chinese patients with systemic lupus erythematosus. , 2015, Tissue antigens.

[20]  Laura J. Scott,et al.  Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways , 2015, Nature Neuroscience.

[21]  Peilin Jia,et al.  Transcriptome Sequencing and Genome-wide Association Analyses Reveal Lysosomal Function and Actin Cytoskeleton Remodeling in Schizophrenia and Bipolar Disorder , 2014, Molecular Psychiatry.

[22]  Yongshuai Jiang,et al.  Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer’s Disease and Parkinson’s Disease , 2014, Molecular Neurobiology.

[23]  Minna Rusanen,et al.  Heart diseases and long-term risk of dementia and Alzheimer's disease: a population-based CAIDE study. , 2014, Journal of Alzheimer's disease : JAD.

[24]  M. Frye,et al.  Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2 , 2014, Molecular Psychiatry.

[25]  Karen S. Frese,et al.  Systematic permutation testing in GWAS pathway analyses: identification of genetic networks in dilated cardiomyopathy and ulcerative colitis , 2014, BMC Genomics.

[26]  Yanay Ofran,et al.  Large Scale Analysis of Phenotype-Pathway Relationships Based on GWAS Results , 2014, PloS one.

[27]  Jacqueline L Johnson,et al.  Power calculation for overall hypothesis testing with high‐dimensional commensurate outcomes , 2014, Statistics in medicine.

[28]  M. Daly,et al.  Searching for missing heritability: Designing rare variant association studies , 2014, Proceedings of the National Academy of Sciences.

[29]  Joseph K. Pickrell.  Joint analysis of functional genomic data and genome-wide association studies of 18 human traits , 2013, bioRxiv.

[30]  K. Kudsk,et al.  JAK-STAT and intestinal mucosal immunology , 2013, JAK-STAT.

[31]  S. Purcell,et al.  Pleiotropy in complex traits: challenges and strategies , 2013, Nature Reviews Genetics.

[32]  Martha L Slattery,et al.  JAK/STAT/SOCS‐signaling pathway and colon and rectal cancer , 2013, Molecular carcinogenesis.

[33]  Marylyn D. Ritchie,et al.  Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network , 2013, PLoS genetics.

[34]  Zhongming Zhao,et al.  Enriched pathways for major depressive disorder identified from a genome-wide association study. , 2012, The international journal of neuropsychopharmacology.

[35]  Colm O'Dushlaine,et al.  INRICH: interval-based enrichment analysis for genome-wide association studies , 2012, Bioinform..

[36]  Peilin Jia,et al.  Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia , 2012, PLoS Comput. Biol..

[37]  R. Plenge,et al.  JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. , 2012, Immunity.

[38]  Zhongming Zhao,et al.  A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia , 2011, Journal of Medical Genetics.

[39]  P. Mortensen,et al.  Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study. , 2011, The American journal of psychiatry.

[40]  Zhongming Zhao,et al.  Pathway-based analysis of GWAS datasets: effective but caution required. , 2011, The international journal of neuropsychopharmacology.

[41]  Frank W. Stearns.  One Hundred Years of Pleiotropy: A Retrospective , 2010, Genetics.

[42]  Peilin Jia,et al.  Common variants conferring risk of schizophrenia: A pathway analysis of GWAS data , 2010, Schizophrenia Research.

[43]  Manuel A. R. Ferreira,et al.  Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. , 2009, American journal of human genetics.

[44]  F. Collins,et al.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.

[45]  P. Matthews,et al.  Pathway and network-based analysis of genome-wide association studies in multiple sclerosis , 2009, Human molecular genetics.

[46]  O. Mors,et al.  Association of schizophrenia and autoimmune diseases: linkage of Danish national registers. , 2006, The American journal of psychiatry.

[47]  Daniel P. Faith,et al.  Compositional dissimilarity as a robust measure of ecological distance , 1987, Vegetatio.

[48]  M Claustres,et al.  Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens. , 1995, The New England journal of medicine.

[49]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[50]  D. Steinberg,et al.  The cholesterol controversy is over. Why did it take so long? , 1989, Circulation.

[51]  Morton B. Brown.  400: A Method for Combining Non-Independent, One-Sided Tests of Significance , 1975 .