The Natural History of Alcoholism

Over the past 55 years, two longitudinal studies have been monitoring the drinking behaviors and their consequences of several hundred men from adolescence and early adulthood to old age. The studies identified co-occurring sociopathy, cultural factors (e.g., ethnicity), and genetic factors (i.e., a family history of alcoholism) as risk factors for alcoholism. n most alcoholics, the disease had a progressive course, resulting in increasing alcohol abuse or stable abstinence. However, some alcoholics exhibited a nonprogressive disease course and either maintained a stable level of alcohol abuse or returned to asymptomatic drinking. Long-term return to controlled drinking, however, was a rare and unstable outcome. Formal treatment, with the exception of attending Alcoholics Anonymous, did not appear to affect the men’s long-term outcomes, whereas several non-treatment-related factors were important for achieving stable recovery.

[1]  J. Kocsis,et al.  A double-blind, placebo-controlled trial of desipramine for primary alcohol dependence stratified on the presence or absence of major depression. , 1996, JAMA.

[2]  M. Schuckit A Long-Term Study of Sons of Alcoholics , 1995, Alcohol health and research world.

[3]  K. Merikangas,et al.  Comorbidity for alcoholism and depression. , 1990, The Psychiatric clinics of North America.

[4]  D. Ostrow,et al.  Lithium treatment of depressed and nondepressed alcoholics. , 1989, JAMA.

[5]  M. Schuckit,et al.  Changes in depression among abstinent alcoholics. , 1988, Journal of studies on alcohol.

[6]  C. Robert Cloninger,et al.  Childhood personality predicts alcohol abuse in young adults. , 1988, Alcoholism, clinical and experimental research.

[7]  R. Jessor Problem-behavior theory, psychosocial development, and adolescent problem drinking. , 1987, British journal of addiction.

[8]  A. Washton,et al.  Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors , 1986 .

[9]  M. Sanchez-Craig,et al.  Disadvantages to imposing the goal of abstinence on problem drinkers: an empirical study. , 1986, British journal of addiction.

[10]  A. Farmer,et al.  The extent of long-term moderate drinking among alcoholics discharged from medical and psychiatric treatment facilities. , 1985, The New England journal of medicine.

[11]  K. Kidd,et al.  Psychiatric disorders in the relatives of probands with affective disorders. The Yale University--National Institute of Mental Health Collaborative Study. , 1984, Archives of general psychiatry.

[12]  J. Chick Alcoholism Treatment in Transition. , 1981 .

[13]  R. Frances,et al.  Studies of familial and nonfamilial alcoholism. I. Demographic studies. , 1980, Archives of general psychiatry.

[14]  G. Bigelow Behavioral Treatment of Alcohol Problems , 1980 .

[15]  Americal Psychiatric Press Diagnostic and Statistical Manual of Mental Disorders, Third Edition , 1980 .

[16]  W. Kurtines,et al.  Personality characteristics of long-term recovered alcoholics: a comparative analysis. , 1978, Journal of consulting and clinical psychology.

[17]  L. Sobell,et al.  Behavioral Treatment of Alcohol Problems , 1978 .

[18]  J. Morrison Bipolar affective disorder and alcoholism. , 1974, The American journal of psychiatry.

[19]  D. W. Goodwin,et al.  Felons who drink: an 8-year follow-up. , 1971, Quarterly journal of studies on alcohol.