Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection.

The instrument development and design of a prototype frequency-domain optical imaging device for breast cancer detection is described in detail. This device employs radio-frequency intensity modulated near-infrared light to image quantitatively both the scattering and absorption coefficients of tissue. The functioning components of the system include a laser diode and a photomultiplier tube, which are multiplexed automatically through 32 large core fiber optic bundles using high precision linear translation stages. Image reconstruction is based on a finite element solution of the diffusion equation. This tool for solving the forward problem of photon migration is coupled to an iterative optical property estimation algorithm, which uses a Levenberg-Marquardt routine with total variation minimization. The result of this development is an automated frequency-domain optical imager for computed tomography which produces quantitatively accurate images of the test phantoms used to date. This paper is a description and characterization of an automated frequency-domain computed tomography scanner, which is more quantitative than earlier systems used in diaphanography because of the combination of intensity modulated signal detection and iterative image reconstruction.

[1]  Enrico Gratton,et al.  Diffusion of intensity-modulated near-infrared light in turbid media , 1991, Photonics West - Lasers and Applications in Science and Engineering.

[2]  Lihong V. Wang,et al.  Monte Carlo Modeling of Light Transport in Multi-layered Tissues in Standard C , 1992 .

[3]  B. Wilson,et al.  Monte Carlo modeling of light propagation in highly scattering tissues. I. Model predictions and comparison with diffusion theory , 1989, IEEE Transactions on Biomedical Engineering.

[4]  M W Vannier,et al.  Image reconstruction of the interior of bodies that diffuse radiation. , 1992, Investigative radiology.

[5]  Simon R. Arridge,et al.  Reconstruction methods for infrared absorption imaging , 1991, Photonics West - Lasers and Applications in Science and Engineering.

[6]  B. Wilson,et al.  A Monte Carlo model for the absorption and flux distributions of light in tissue. , 1983, Medical physics.

[7]  A E Profio,et al.  Contrast in diaphanography of the breast. , 1988, Medical physics.

[8]  A E Profio,et al.  Scientific basis of breast diaphanography. , 1989, Medical physics.

[9]  K. Paulsen,et al.  Spatially varying optical property reconstruction using a finite element diffusion equation approximation. , 1995, Medical physics.

[10]  Akira Ishimaru,et al.  Wave propagation and scattering in random media , 1997 .

[11]  P M Schlag,et al.  Frequency-domain techniques enhance optical mammography: initial clinical results. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[12]  M. Schweiger,et al.  Image reconstruction in optical tomography. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[13]  B. Pogue,et al.  Optical image reconstruction using frequency-domain data: simulations and experiments , 1996 .

[14]  Britton Chance,et al.  Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women. , 1996, Journal of biomedical optics.

[15]  R. Arridget,et al.  The theoretical basis for the determination of optical pathlengths in tissue: temporal and frequency analysis , 1992 .

[16]  D. Boas,et al.  Experimental images of heterogeneous turbid media by frequency-domain diffusing-photon tomography. , 1995, Optics letters.

[17]  B. Tromberg,et al.  Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[18]  B. Wilson,et al.  Frequency-domain reflectance for the determination of the scattering and absorption properties of tissue. , 1991, Applied optics.

[19]  K D Paulsen,et al.  Enhanced frequency-domain optical image reconstruction in tissues through total-variation minimization. , 1996, Applied optics.

[20]  E. Gratton,et al.  Image reconstruction by backprojection from frequency-domain optical measurements in highly scattering media. , 1997, Applied optics.

[21]  A Ishimaru,et al.  Diffusion of light in turbid material. , 1989, Applied optics.

[22]  G. Weiss,et al.  Model for photon migration in turbid biological media. , 1987, Journal of the Optical Society of America. A, Optics and image science.

[23]  M S Patterson,et al.  Error assessment of a wavelength tunable frequency domain system for noninvasive tissue spectroscopy. , 1996, Journal of biomedical optics.

[24]  L. Tabár,et al.  Lightscanning versus mammography for the detection of breast cancer in screening and clinical practice. A Swedish multicenter study , 1990, Cancer.

[25]  L. O. Svaasand,et al.  Properties of photon density waves in multiple-scattering media. , 1993, Applied optics.

[26]  V. Sobolev,et al.  A treatise on radiative transfer. , 1963 .

[27]  P. Jackson,et al.  The development of a system for transillumination computed tomography. , 1987, The British journal of radiology.

[28]  M S Patterson,et al.  Optical properties of normal and diseased human breast tissues in the visible and near infrared. , 1990, Physics in medicine and biology.

[29]  V V Tuchin,et al.  Effect of the scattering delay on time-dependent photon migration in turbid media. , 1997, Applied optics.

[30]  T L Troy,et al.  Optical properties of normal and diseased breast tissues: prognosis for optical mammography. , 1996, Journal of biomedical optics.

[31]  D. Watmough,et al.  Transillumination of breast tissues: factors governing optimal imaging of lesions. , 1983, Radiology.