Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic

[1]  Joan Eilstein,et al.  Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[2]  R. Edwards,et al.  Elucidation of Xenobiotic Metabolism Pathways in Human Skin and Human Skin Models by Proteomic Profiling , 2012, PloS one.

[3]  Jean Krutmann,et al.  Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte‐based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I) , 2012, Experimental dermatology.

[4]  Gillian Smith,et al.  Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1 , 2012, Drug Metabolism and Disposition.

[5]  R L Binder,et al.  Xenobiotic metabolism gene expression in the EpiDermin vitro 3D human epidermis model compared to human skin. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[6]  V. Lokeshwar,et al.  Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells. , 2010, Cancer research.

[7]  Dale Hattis,et al.  Genetic Polymorphism in N-Acetyltransferase (NAT): Population Distribution of NAT1 and NAT2 Activity , 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

[8]  Fernand Labrie,et al.  Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin™ and full thickness model from Episkin™ , 2009, The Journal of Steroid Biochemistry and Molecular Biology.

[9]  C. K. Svensson,et al.  Biotransformation of Drugs in Human Skin , 2009, Drug Metabolism and Disposition.

[10]  J. Cravedi,et al.  Biotransformation of vinclozolin in rat precision-cut liver slices: comparison with in vivo metabolic pattern. , 2008, Journal of agricultural and food chemistry.

[11]  Sue Gibbs,et al.  Xenobiotic metabolism in human skin and 3D human skin reconstructs: a review. , 2007, Current drug metabolism.

[12]  F. Williams,et al.  Specificity of Procaine and Ester Hydrolysis by Human, Minipig, and Rat Skin and Liver , 2007, Drug Metabolism and Disposition.

[13]  P. Gerk,et al.  Simultaneous determination of 1-chloro-2,4-dinitrobenzene, 2,4-dinitrophenyl-S-glutathione and its metabolites for human placental disposition studies by high-performance liquid chromatography. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[14]  P. Bélanger,et al.  Steroid metabolism and profile of steroidogenic gene expression in Episkin™: High similarity with human epidermis , 2007, The Journal of Steroid Biochemistry and Molecular Biology.

[15]  D. Pérez-Sala,et al.  Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. , 2007, Archives of biochemistry and biophysics.

[16]  Robert Landsiedel,et al.  Drug-Metabolizing Enzymes in the Skin of Man, Rat, and Pig , 2007, Drug metabolism reviews.

[17]  D. Tobin,et al.  Biochemistry of human skin--our brain on the outside. , 2006, Chemical Society reviews.

[18]  C. Falany,et al.  Characterization of Proline-Serine-Rich Carboxyl Terminus in Human Sulfotransferase 2B1b: Immunogenicity, Subcellular Localization, Kinetic Properties, and Phosphorylation , 2006, Drug Metabolism and Disposition.

[19]  K. Kong,et al.  Purification and biochemical properties of glutathione S-transferase from Lactuca sativa. , 2005, Journal of biochemistry and molecular biology.

[20]  Te-Mao Li,et al.  Evidence for arylamine N-acetyltransferase activity in Klebsiella pneumoniae. , 2004, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[21]  A. Galetin,et al.  Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid. , 2004, Drug metabolism and disposition: the biological fate of chemicals.

[22]  K. Wittern,et al.  Comparison of Activities Dependent on Glutathione S-Transferase and Cytochrome P-450 IA1 in Cultured Keratinocytes and Reconstructed Epidermal Models , 2002, Skin Pharmacology and Physiology.

[23]  S. D. Turner,et al.  Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates. , 2000, Drug metabolism and disposition: the biological fate of chemicals.

[24]  H. Mukhtar,et al.  Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1. , 2000, The Journal of investigative dermatology.

[25]  N. Ballatori,et al.  Endogenous glutathione conjugates: occurrence and biological functions. , 1998, Pharmacological reviews.

[26]  G. Chang,et al.  Kinetic mechanism of octopus hepatopancreatic glutathione transferase in reverse micelles. , 1996, The Biochemical journal.

[27]  Y. Berger,et al.  Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes. , 1996, The Journal of pharmacology and experimental therapeutics.

[28]  S. Ekins,et al.  Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes. , 1995, Drug metabolism and disposition: the biological fate of chemicals.

[29]  J. Thivolet,et al.  In vitro and post-transplantation differentiation of human keratinocytes grown on the human type IV collagen film of a bilayered dermal substitute. , 1991, Experimental cell research.

[30]  P. K. Smith,et al.  Measurement of protein using bicinchoninic acid. , 1985, Analytical biochemistry.

[31]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[32]  H. Kondo,et al.  S → N AND N → S REVERSE REARRANGEMENT OF S- AND N-(2,4-DINITROPHENYL)CYSTEINES , 1981 .

[33]  H. Kondo,et al.  S .fwdarw. N and N .fwdarw. S reverse rearrangement of S- and N-(2,4-dinitrophenyl)cysteines , 1981 .

[34]  U. Kürschner.  Untersuchungen zur Toxizität und Biotransformation an der humanen Keratinozytenzelllinie HaCaT , 2007 .

[35]  D. Zalko,et al.  Comparative metabolism of clenbuterol by rat and bovine liver microsomes and slices. , 1998, Drug metabolism and disposition: the biological fate of chemicals.

[36]  J. Cotovio,et al.  Effect of imidazole derivatives on cytochrome P-450 enzyme activities in a reconstructed human epidermis. , 1996, Skin pharmacology : the official journal of the Skin Pharmacology Society.