Introducing triage logic as a new strategy for the detection of signals in the WHO Drug Monitoring Database

An important role for the WHO Programme for International Drug Monitoring is to identify signals of international drug safety problems as early as possible. The signal detection strategy, operated at the Uppsala Monitoring Centre (UMC), gave too many drug–adverse drug reaction (ADR) combinations for individual review. Therefore additional selection strategies were needed to improve the likely signal‐to‐noise ratio and for the UMC to complement the efforts of national centres in an efficient way.