Instrumentation and calibration protocol for imaging dynamic features in dense-scattering media by optical tomography.

Instrumentation is described that is suitable for acquiring multisource, multidetector, time-series optical data at high sampling rates (up to 150 Hz) from tissues having arbitrary geometries. The design rationale, calibration protocol, and measured performance features are given for both a currently used, CCD-camera-based instrument and a new silicon-photodiode-based system under construction. Also shown are representative images that we reconstructed from data acquired in laboratory studies using the described CCD-based instrument.

[1]  C L Odoroff,et al.  Capillary recruitment in exercise: rate, extent, uniformity, and relation to blood flow. , 1980, The American journal of physiology.

[2]  K Paulsen,et al.  Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection. , 1997, Optics express.

[3]  S. Arridge,et al.  Nonuniqueness in diffusion-based optical tomography. , 1998, Optics letters.

[4]  David Friedman,et al.  Rapid Changes of Optical Parameters in the Human Brain During a Tapping Task , 1995, Journal of Cognitive Neuroscience.

[5]  Y Wang,et al.  Regularized progressive expansion algorithm for recovery of scattering media from time-resolved data. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[6]  S Sundberg,et al.  Drug- and temperature-induced changes in peripheral circulation measured by laser-Doppler flowmetry and digital-pulse plethysmography. , 1986, Scandinavian journal of clinical and laboratory investigation.

[7]  H Witte,et al.  Dynamic coherence analysis of vasomotion and flow motion in skeletal muscle microcirculation. , 1996, Microvascular research.

[8]  S R Arridge,et al.  Simultaneous reconstruction of absorption and scattering images by multichannel measurement of purely temporal data. , 1999, Optics letters.

[9]  Y. Kakihana,et al.  Dynamic changes in intracapillary hemoglobin oxygenation in human skin following various temperature changes. , 1998, Microvascular research.

[10]  Britton Chance,et al.  Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II , 1997 .

[11]  Jody T. Bruulsema,et al.  Correlation between blood glucose concentration in diabetics and noninvasively measured tissue optical scattering coefficient. , 1997, Optics letters.

[12]  Y Pei,et al.  Modeling of sensitivity and resolution to an included object in homogeneous scattering media and in MRI-derived breast maps. , 1999, Optics express.

[13]  Peter M. Schlag,et al.  Time-domain optical mammography: results on phantoms, healthy volunteers, and patients , 1998 .

[14]  J. Hogg.  Magnetic resonance imaging. , 1994, Journal of the Royal Naval Medical Service.

[15]  L. Glass,et al.  From Clocks to Chaos: The Rhythms of Life , 1988 .

[16]  Shoko Nioka,et al.  Breast tumor detection using continuous wave light source , 1995, Photonics West.

[17]  Randall L. Barbour,et al.  Dynamic optical tomography: A new approach for investigating tissue-vascular coupling in large tissue sructures , 2000 .

[18]  Richard J. Grable,et al.  Optical tomography breast imaging , 1997, Photonics West - Biomedical Optics.

[19]  Andreas H. Hielscher,et al.  Parallelization of gradient-based iterative image reconstruction scheme , 2000 .

[20]  R. Barbour,et al.  Influence of Systematic Errors in Reference States on Image Quality and on Stability of Derived Information for dc Optical Imaging. , 2001, Applied optics.

[22]  G. M. Hale,et al.  Optical Constants of Water in the 200-nm to 200-microm Wavelength Region. , 1973, Applied optics.

[23]  R. Khurana.  Autonomic failure: A textbook of clinical disorders of the autonomic nervous system, 4th ed , 2000 .

[24]  Dario Fasino,et al.  An inverse Robin problem for Laplace's equation: theoretical results and numerical methods , 1999 .

[25]  R. Alcouffe,et al.  Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues. , 1998, Physics in medicine and biology.

[26]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[27]  C H Schmitz,et al.  Optical tomographic imaging of dynamic features of dense-scattering media. , 2001, Journal of the Optical Society of America. A, Optics, image science, and vision.

[28]  D. Goldstein.  Autonomic Failure: A Textbook of Clinical Disorders of the Autonomic Nervous System , 1985 .

[29]  B Chance,et al.  Near‐Infrared Images Using Continuous, Phase‐Modulated, and Pulsed Light with Quantitation of Blood and Blood Oxygenation a , 1998, Annals of the New York Academy of Sciences.

[30]  S. Arridge.  Optical tomography in medical imaging , 1999 .

[31]  Alessandro Torricelli,et al.  Quantitative imaging in time-resolved transillumination experiments using time-dependent contrast functions , 1999, Photonics West - Biomedical Optics.

[32]  Harry L. Graber,et al.  Algebraic reconstruction of images of a diffusive medium containing strong absorbers: comparative study of different illumination schemes and the effect of restricted view angle , 1995, Photonics West.

[33]  D. Delpy,et al.  Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation. , 1988, Biochimica et biophysica acta.

[34]  J. Brobeck,et al.  Best and Taylorʼs Physiological Basis of Medical Practice , 1977 .

[35]  I. Driver,et al.  The optical properties of aqueous suspensions of Intralipid, a fat emulsion , 1989 .

[36]  D. Boas,et al.  Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation , 1997 .

[37]  Yukio Yamada,et al.  Multichannel time-resolved optical tomographic imaging system , 1999 .

[38]  P. Rousseeuw.  Robust estimation and identifying outliers , 1990 .

[39]  B. Pogue,et al.  Comparison of imaging geometries for diffuse optical tomography of tissue. , 1999, Optics express.

[40]  S Nioka,et al.  Optical imaging of human breast cancer. , 1994, Advances in experimental medicine and biology.

[41]  James G. Fujimoto,et al.  Advances in Optical Imaging and Photon Migration , 1996 .

[42]  H Szmacinski,et al.  Frequency domain imaging of absorbers obscured by scattering. , 1992, Journal of photochemistry and photobiology. B, Biology.

[43]  S L Jacques,et al.  Optical properties of intralipid: A phantom medium for light propagation studies , 1992, Lasers in surgery and medicine.

[44]  J. Marota,et al.  Design and evaluation of a continuous-wave diffuse optical tomography system. , 1999, Optics express.

[45]  Harry L. Graber,et al.  Development and evaluation of the IRIS–OPTIscanner, a general-purpose optical tomographic imaging system , 1998 .

[46]  J. Melissen,et al.  Tomographic image reconstruction from optical projections in light-diffusing media. , 1997, Applied optics.

[47]  A Maki,et al.  Measurement system for noninvasive dynamic optical topography. , 1999, Journal of biomedical optics.

[48]  A G Yodh,et al.  Detection and characterization of optical inhomogeneities with diffuse photon density waves: a signal-to-noise analysis. , 1997, Applied optics.

[49]  Harry L. Graber,et al.  Imaging of differential reactivity of the vascular tree in the human forearm by optical tomography , 2000 .

[50]  R R Alfano,et al.  Time‐Resolved and Nonlinear Optical Imaging for Medical Applications a , 1998, Annals of the New York Academy of Sciences.