Solvent-free synthesis, spectral correlations and antimicrobial activities of some 2′, 3′, 4′-trichlorophenyl chalcones

Background: This study aimed to synthesize some 2′, 3′, 4′-trichlorophenyl chalcones [(E)-1-(2, 3, 4-trichlorophenyl)-3-(substituted phenyl)-2-propen-1-ones] using solvent-free sulfated Titania catalyzed aldol condensation between 2, 3, 4-trichloroacetophenone and substituted benzaldehydes under microwave irradiation. To characterize these chalcones using analytical, physical and spectroscopic data and also to study their the spectral correlation and antimicrobial activities. Methods: Solvent free microwave assisted aldol condensation method was used for synthesizing substituted styryl 2′, 3′, 4′-trichlorophenyl ketones. They were characterized by UV, IR, NMR and mass spectroscopic data. The UV, IR, NMR spectral data were correlated with substituent constants, F and R parameters, using Hammett equation, to study the effect of substituents. The Bauer-Kirby method was used for the evaluation of antimicrobial activities of the synthesized chalcones. Results: The yields of the synthesized chalcones were more ...

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