Isomer-specific separation of 2378-substituted polychlorinated dibenzo-p-dioxins by high-resolution gas chromatography/mass spectrometry

All polychlorinated dibenzo-p-dioxin (PCDD) isomers containing four and more chlorine substituents were prepared by micropyrolysis of chlorophenates. The syntheses included the preparation of all 22 tetra-, 14 penta-, 10 hexa-, 2 hepta-, and octachlorinated species (tetra- to octa-CDD). The gas chromatographic and mass spectrometric properties of these isomers were studied. High-resolution gas chromatography (HRGC) on a 55-m Silar 10 c glass capillary column allowed the separation of many of these isomers and allowed the unambiguous assignment of the toxic and environmentally hazardous 2378-substituted isomers (2378-tetra-, 12378-penta, 123478-, 123678-, and 123789-hexa-CDD). Analyses were carried out to determine the occurrence of these isomers in environmental samples and in fly ash from municipal incinerators.

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