Differential coexpression network modules observed in human hepatocellular carcinoma progression

Background While an understanding of the human interactome is within attainable reach [1], an impending challenge is to uncover the condition-specific dynamics of the proteinprotein interaction (PPI) network, especially those that coordinate with disease progression [2]. Differential coexpression analysis (DCA) [3,4] has recently emerged as an effective approach to address this issue, but such an effort has yet to be thoroughly tested.