A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway
暂无分享,去创建一个
Dimitrios Vlachakis | Leonidas Stefanis | L. Stefanis | D. Vlachakis | W. Dauer | S. Przedborski | Katerina Melachroinou | Serge Przedborski | D. Re | H. Rideout | Katerina Melachroinou | William T. Dauer | Diane B. Re | Hardy J. Rideout | Nasia Antoniou | Anna Memou | Emmanouela Leandrou | Polytimi-Eleni Valkimadi | Nasia Antoniou | Polytimi-Eleni Valkimadi | Anna Memou | Emmanouela Leandrou
[1] G. Hadjigeorgiou,et al. Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations , 2016, PloS one.
[2] Robert F Gahl,et al. Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis , 2016, Cell Death and Disease.
[3] Young Ho Suh,et al. Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy , 2016, PloS one.
[4] M. Ueffing,et al. Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts , 2016, Proceedings of the National Academy of Sciences.
[5] Matthias Mann,et al. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases , 2016, eLife.
[6] D. Longley,et al. DED or alive: assembly and regulation of the death effector domain complexes , 2015, Cell Death and Disease.
[7] H. Miyatake,et al. Crystal Structure of Human Importin-α1 (Rch1), Revealing a Potential Autoinhibition Mode Involving Homodimerization , 2015, PloS one.
[8] J. Martinou,et al. Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis. , 2014, Chemistry and physics of lipids.
[9] G. Garden,et al. Bax Interacting Factor-1 Promotes Survival and Mitochondrial Elongation in Neurons , 2014, The Journal of Neuroscience.
[10] Marta Tormos-Pérez,et al. Structural and functional in silico analysis of LRRK2 missense substitutions , 2014, Molecular Biology Reports.
[11] M. Cookson,et al. Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies , 2014, The Journal of Neuroscience.
[12] Marta Tormos-Pérez,et al. Structural and functional in silico analysis of LRRK 2 missense substitutions , 2014 .
[13] M. Cookson,et al. Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers , 2012, PloS one.
[14] T. Yeh,et al. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD , 2012, Cell Death and Differentiation.
[15] Mark Ellisman,et al. LRRK2 Parkinson disease mutations enhance its microtubule association. , 2011, Human molecular genetics.
[16] Wei Lu,et al. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease , 2011, Nature Immunology.
[17] Zhiheng Xu,et al. Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system. , 2011, Bioscience reports.
[18] C. Schnell,et al. LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice , 2011, Human molecular genetics.
[19] H. Walczak,et al. Caspase-8 and bid: caught in the act between death receptors and mitochondria. , 2011, Biochimica et biophysica acta.
[20] 張文騰. 台灣族群帕金森氏症Leucine-Rich Repeat Kinase 2 (LRRK2) 基因變異的分子功能研究 , 2011 .
[21] F. Sun,et al. Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2. , 2010, Biochimica et biophysica acta.
[22] U. Stochaj,et al. Dissecting the Signaling Events That Impact Classical Nuclear Import and Target Nuclear Transport Factors , 2009, PloS one.
[23] G. Gores,et al. Life and death by death receptors , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[24] W. Lasoń,et al. Protective Effect of Memantine Against Doxorubicin Toxicity in Primary Neuronal Cell Cultures: Influence a Development Stage , 2009, Neurotoxicity Research.
[25] W. Dauer,et al. The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration , 2009, The Journal of Neuroscience.
[26] Boguslaw Stec,et al. The Fas/FADD death domain complex structure unravels signaling by receptor clustering , 2008, Nature.
[27] M. Cookson,et al. The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation* , 2008, Journal of Biological Chemistry.
[28] M. P. van der Brug,et al. Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1 , 2007, Journal of neurochemistry.
[29] P. Barone,et al. Apoptotic mechanisms in mutant LRRK2-mediated cell death. , 2007, Human molecular genetics.
[30] Hynek Wichterle,et al. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons , 2007, Nature Neuroscience.
[31] K. Lim,et al. Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. , 2007, Human molecular genetics.
[32] J. Johnson,et al. Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants , 2007, European journal of neurology.
[33] M. H. Werner,et al. FADD self-association is required for stable interaction with an activated death receptor , 2006, Cell Death and Differentiation.
[34] C. Ross,et al. Kinase activity of mutant LRRK2 mediates neuronal toxicity , 2006, Nature Neuroscience.
[35] David W. Miller,et al. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin , 2006, Neurobiology of Disease.
[36] M. H. Werner,et al. The structure of FADD and its mode of interaction with procaspase-8. , 2006, Molecular cell.
[37] Andrew B West,et al. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[38] G. Rosenberg,et al. Vulnerability of mouse cortical neurons to doxorubicin-induced apoptosis is strain-dependent and is correlated with mRNAs encoding Fas, Fas-Ligand, and metalloproteinases , 2004, Apoptosis.
[39] Maurizio Pellecchia,et al. Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules. , 2004, Chemistry & biology.
[40] A J Carlson,et al. Frederick R. Rickles, MD, FACP, Appointed Executive Director of the Federation of American Societies for Experimental Biology , 2004, Journal of Investigative Medicine.
[41] J. Cidlowski,et al. Molecular evidence for the nuclear localization of FADD , 2003, Cell Death and Differentiation.
[42] L. Stefanis,et al. Proteasomal Inhibition-Induced Inclusion Formation and Death in Cortical Neurons Require Transcription and Ubiquitination , 2002, Molecular and Cellular Neuroscience.
[43] J. Tschopp,et al. Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling , 2002, FEBS letters.
[44] S. Korsmeyer,et al. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[45] J. Bertin,et al. Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis , 1998, The Journal of cell biology.
[46] E. White,et al. E1B 19K Inhibits Fas-mediated Apoptosis through FADD-dependent Sequestration of FLICE , 1998, The Journal of cell biology.
[47] Stephen W. Fesik,et al. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain , 1998, Nature.