Physiological significance of metabolic channelling.

[1]  G. Pettersson,et al.  Evidence that 1,3-bisphosphoglycerate dissociation from phosphoglycerate kinase is an intrinsically rapid reaction step. , 1989, European journal of biochemistry.

[2]  L. Bülow.  Characterization of an artificial bifunctional enzyme, beta-galactosidase/galactokinase, prepared by gene fusion. , 1987, European journal of biochemistry.

[3]  G. Hervé,et al.  In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. 3. Catalytic and regulatory properties of carbamylphosphate synthetase: channeling of carbamylphosphate to aspartate transcarbamylase. , 1988, Archives of biochemistry and biophysics.

[4]  S. Wakil,et al.  Fatty acid synthase, a proficient multifunctional enzyme. , 1989, Biochemistry.

[5]  M. Vas,et al.  Evidence for absence of an interaction between purified 3-phosphoglycerate kinase and glyceraldehyde-3-phosphate dehydrogenase. , 1981, Biochimica et biophysica acta.

[6]  H. O. Spivey,et al.  Substrate channeling of NADH and binding of dehydrogenases to complex I. , 1989, The Journal of biological chemistry.

[7]  H. O. Spivey,et al.  Substrate channeling of oxalacetate in solid-state complexes of malate dehydrogenase and citrate synthase. , 1985, The Journal of biological chemistry.

[8]  J. Clegg,et al.  Evidence for intermediate channelling in the glycolytic pathway of permeabilized L-929 cells. , 1989, Biochemical and biophysical research communications.

[9]  C. Mathews,et al.  Functional compartmentation of DNA precursors in T4 phage-infected bacteria. , 1978, The Journal of biological chemistry.

[10]  M. Watford.  Channeling in the urea cycle: a metabolon spanning two compartments. , 1989, Trends in biochemical sciences.

[11]  H. Miziorko,et al.  Evidence for substrate channeling in the early steps of cholesterogenesis. , 1990, The Journal of biological chemistry.

[12]  J. Ovádi,et al.  A simple approach to identify the mechanism of intermediate transfer: enzyme system related to triose phosphate metabolism. , 1987, Biochimica et biophysica acta.

[13]  H. Schulz,et al.  Channeling of 3-hydroxy-4-trans-decenoyl coenzyme A on the bifunctional beta-oxidation enzyme from rat liver peroxisomes and on the large subunit of the fatty acid oxidation complex from Escherichia coli. , 1986, The Journal of biological chemistry.

[14]  M. Schlame,et al.  Dynamic compartmentation of adenine nucleotides in the mitochondrial intermembrane space of rat-heart mitochondria. , 1987, Biochimica et biophysica acta.

[15]  J. Ovádi,et al.  Kinetic and physico-chemical analysis of enzyme complexes and their possible role in the control of metabolism. , 1989, Progress in biophysics and molecular biology.

[16]  H. Westerhoff,et al.  On the origin of the limited control of mitochondrial respiration by the adenine nucleotide translocator. , 1987, Archives of biochemistry and biophysics.

[17]  Welch Gr,et al.  Enzyme Organization in the Polyaromatic—Biosynthetic Pathway: The arom Conjugate and Other Multienzyme Systems* , 1980 .

[18]  L. Raijman,et al.  Channeling of extramitochondrial ornithine to matrix ornithine transcarbamylase. , 1987, Journal of Biological Chemistry.

[19]  E. Padlan,et al.  Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium. , 1988, The Journal of biological chemistry.

[20]  J. S. Easterby,et al.  Coupled enzyme assays: a general expression for the transient. , 1973, Biochimica et biophysica acta.

[21]  F. Kwok,et al.  Interactions of pyridoxal kinase and aspartate aminotransferase emission anisotropy and compartmentation studies. , 1988, The Journal of biological chemistry.

[22]  J Ovádi,et al.  How to determine the efficiency of intermediate transfer in an interacting enzyme system? , 1987, FEBS letters.

[23]  J. Hajdu,et al.  An overview of supramolecular enzyme organization. , 1987, Biochemical Society transactions.

[24]  J. Ovádi,et al.  Control of metabolism by dynamic macromolecular interactions. , 1988, Current topics in cellular regulation.

[25]  V. Muronetz,et al.  Interaction between D-glyceraldehyde-3-phosphate dehydrogenase and 3-phosphoglycerate kinase labeled by fluorescein-5'-isothiocyanate: evidence that the dye participates in the interaction. , 1989, Biochemical and biophysical research communications.

[26]  J Ovádi,et al.  A simple approach to detect active-site-directed enzyme-enzyme interactions. The aldolase/glycerol-phosphate-dehydrogenase enzyme system. , 1987, European journal of biochemistry.

[27]  Z. Dinya,et al.  New vistas for P-aminobenzoate participation in the biosynthesis of dihydro folate: a tentative model of the tetrahydro folate multienzyme complex. , 1975, Bio Systems.

[28]  John Eric Wilson.  Ambiquitous enzymes: Variation in intracellular distribution as a regulatory mechanism , 1978 .

[29]  L. Reed,et al.  Use of trypsin and lipoamidase to study the role of lipoic acid moieties in the pyruvate and alpha-ketoglutarate dehydrogenase complexes of Escherichia coli. , 1981, Biochemistry.

[30]  R. Christopherson,et al.  The overall synthesis of L-5,6-dihydroorotate by multienzymatic protein pyr1-3 from hamster cells. Kinetic studies, substrate channeling, and the effects of inhibitors. , 1980, The Journal of biological chemistry.

[31]  S. Bernhard,et al.  Halibut muscle 3-phosphoglycerate kinase. Chemical and physical properties of the enzyme and its substrate complexes. , 1982, Biochemistry.

[32]  B. Alberts,et al.  Efficient in vitro replication of double-stranded DNA templates by a purified T4 bacteriophage replication system. , 1980, The Journal of biological chemistry.

[33]  H. Sauro,et al.  Enzyme-enzyme interactions and control analysis. 2. The case of non-independence: heterologous associations. , 1990, European journal of biochemistry.

[34]  H. O. Spivey,et al.  Kinetics of the coupled aspartate aminotransferase-malate dehydrogenase reactions and instability of oxaloacetate on anion-exchange resin. , 1980, Archives of biochemistry and biophysics.

[35]  G. Pettersson,et al.  Mechanism of glyceraldehyde-3-phosphate transfer from aldolase to glyceraldehyde-3-phosphate dehydrogenase. , 1988, European journal of biochemistry.

[36]  C. Mathews,et al.  Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells. , 1982, The Journal of biological chemistry.

[37]  F. Gaertner.  Unique catalytic properties of enzyme clusters , 1978 .

[38]  J. Ovádi,et al.  Kinetics of coupled reactions catalyzed by aspartate aminotransferase and glutamate dehydrogenase. , 1982, European journal of biochemistry.

[39]  D. Mann,et al.  Protein serine/threonine phosphatases; an expanding family , 1990, FEBS letters.

[40]  G R Welch,et al.  The control of cell metabolism for homogeneous vs. heterogeneous enzyme systems. , 1988, Journal of theoretical biology.

[41]  M. J. MacDonald,et al.  Kinetic advantages of hetero-enzyme complexes with glutamate dehydrogenase and the alpha-ketoglutarate dehydrogenase complex. , 1989, The Journal of biological chemistry.

[42]  P. Friedrich,et al.  The 'enzyme-probe' method for characterizing metabolite pools. The use of NAD-glycohydrolase in human erythrocyte sonicate as a model system. , 1979, European journal of biochemistry.

[43]  A. Cornish-Bowden,et al.  The kinetics of coupled enzyme reactions. Applications to the assay of glucokinase, with glucose 6-phosphate dehydrogenase as coupling enzyme. , 1974, The Biochemical journal.

[44]  S. Rapoport,et al.  A reappraisal of the binding of cytosolic enzymes to erythrocyte membranes. , 1989, Trends in biochemical sciences.

[45]  J. Mowbray,et al.  The tentative identification in Escherichia coli of a multienzyme complex with glycolytic activity. , 1976, European journal of biochemistry.

[46]  S. Bernhard,et al.  Mechanism of transfer of reduced nicotinamide adenine dinucleotide among dehydrogenases. Transfer rates and equilibria with enzyme-enzyme complexes. , 1987, Biochemistry.

[47]  P. Tompa,et al.  Interaction of enzymes involved in triosephosphate metabolism. Comparison of yeast and rabbit muscle cytoplasmic systems. , 1986, European journal of biochemistry.

[48]  J Ovádi,et al.  Old pathway--new concept: control of glycolysis by metabolite-modulated dynamic enzyme associations. , 1988, Trends in biochemical sciences.

[49]  J. Ovádi,et al.  Kinetic pathways of formation and dissociation of the glycerol-3-phosphate dehydrogenase-fructose-1,6-bisphosphate aldolase complex. , 1985, The Biochemical journal.

[50]  Tryptophan synthetase of E. coli: a multifunctional, multicomponent enzyme; a commentary on ‘A second reaction catalyzed by the trypotophan synthetase of Escherichia coli’ by C. Yanofsky Biochim. Biophys. Acta 31 (1959) 408–416 , 1989 .

[51]  P. Reichard,et al.  Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts. , 1985, The Journal of biological chemistry.

[52]  R. Perham,et al.  Lipoic acid residues in a take-over mechanism for the pyruvate dehydrogenase multienzyme complex of Escherichia coli. , 1981, Biochemical Journal.

[53]  M. Cárdenas,et al.  A functional five-enzyme complex of chloroplasts involved in the Calvin cycle. , 1988, European journal of biochemistry.

[54]  S. Bernhard,et al.  Metabolite transfer via enzyme-enzyme complexes. , 1986, Science.

[55]  J. S. Easterby.  The analysis of metabolite channelling in multienzyme complexes and multifunctional proteins. , 1989, The Biochemical journal.

[56]  G. Wagner,et al.  Endoplasmic reticulum as a site of phenylpropanoid and flavonoid metabolism in hippeastrum. , 1984, Plant physiology.

[57]  J. G. Cory,et al.  Studies directed toward testing the "channeling" hypothesis--ribonucleotides----DNA in leukemia L1210 cells. , 1984, Biochemical and biophysical research communications.

[58]  S. Bernhard,et al.  Transfer of 1,3-diphosphoglycerate between glyceraldehyde-3-phosphate dehydrogenase and 3-phosphoglycerate kinase via an enzyme-substrate-enzyme complex. , 1982, Biochemistry.

[59]  C. Mathews,et al.  Eukaryotic DNA metabolism. Are deoxyribonucleotides channeled to replication sites? , 1986, Experimental cell research.

[60]  P. Srere,et al.  Complexes of sequential metabolic enzymes. , 1987, Annual review of biochemistry.

[61]  P. Fasella,et al.  The anomalous kinetics of coupled aspartate aminotransferase and malate dehydrogenase. Evidence for compartmentation of oxaloacetate. , 1976, The Biochemical journal.

[62]  P. Srere.  Protein crystals as a model for mitochondrial matrix proteins , 1981 .

[63]  P. Cook,et al.  Initial kinetic characterization of the multienzyme complex, cysteine synthetase , 1977 .

[64]  G. R. Welch,et al.  On the role of organized multienzyme systems in cellular metabolism: a general synthesis. , 1977, Progress in biophysics and molecular biology.

[65]  J. Ovádi,et al.  Enzyme‐enzyme interactions and their metabolic role , 1990, FEBS letters.

[66]  J. Ovádi,et al.  Kinetic evidence for interaction between aldolase and D-glyceraldehyde-3-phosphate dehydrogenase. , 1978, European journal of biochemistry.

[67]  B. Hess,et al.  Transient time of the pyruvate kinase‐lactate dehydrogenase system of rabbit muscle in vitro , 1970, FEBS letters.

[68]  C. Masters.  Metabolic control and the microenvironment. , 1977, Current topics in cellular regulation.

[69]  G R Welch,et al.  Transient-time analysis of substrate-channelling in interacting enzyme systems. , 1989, The Biochemical journal.

[70]  K. Mosbach,et al.  Metabolic compartmentation: symbiotic, organellar, multienzymic, and microenvironmental. , 1974, Annual review of microbiology.

[71]  Daniel E. Atkinson,et al.  Limitation of Metabolite Concentrations and the Conservation of Solvent Capacity in the Living Cell , 1969 .