论文信息 - Polylink: to support two-point linkage analysis in autotetraploids

Polylink: to support two-point linkage analysis in autotetraploids

SUMMARY Polylink runs under Microsoft Windows (95 or later). It performs various calculations that are useful for investigating two-point linkage analysis for autopolyploids, based on the random chromosome pairing model. These include calculation of offspring phenotypic probabilities as functions of the recombination fraction, calculation of theoretical standard errors for the maximum likelihood estimator of and numerical computation of maximum likelihood estimates. It also includes simulation facilities. AVAILABILITY Polylink is free and available from Xiangming Xu via email

[1] R. C. Jackson,et al. Gene segregation in autotetraploids: prediction from meiotic configurations , 1996 .

[2] C. Hackett,et al. Linkage analysis in tetraploid species: a simulation study , 1998 .

[3] K. P. Pauls,et al. Segregation of random amplified polymorphic DNA markers and strategies for molecular mapping in tetraploid alfalfa. , 1993, Genome.

[4] C. Hackett,et al. Linkage analysis in tetraploid potato and association of markers with quantitative resistance to late blight (Phytophthora infestans) , 1998, Molecular and General Genetics MGG.

[5] G A Churchill,et al. Statistical aspects of genetic mapping in autopolyploids. , 1999, Gene.

[6] R. Fisher. ALLOWANCE FOR DOUBLE REDUCTION IN THE CALCULATION OF GENOTYPE FREQUENCIES WITH POLYSOMIC INHERITANCE , 1943 .

[7] Rory A. Fisher,et al. The theory of linkage in polysomic inheritance , 1947, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.