BANGO SEA XLOC/HMBC-H2OBC: complete heteronuclear correlation within minutes from one NMR pulse sequence.

Novel NMR experiments, BANGO SEA XLOC-H2OBC or BANGO HMBC-H2OBC, can deliver complete heteronuclear correlation maps on a time scale of minutes for small molecules. By way of example, it is demonstrated that all intra- and inter-residue 1H and 13C correlations and assignments of a trisaccharide are obtained in 20 or 5 minutes of instrument time without or with 25% NUS, respectively.

[1]  K. Kövér,et al.  Resolution Enhancement in SEA XLOC for Heteronuclear NMR Long‐Range Correlation , 2019, ChemistryOpen.

[2]  E. Kupče,et al.  Triplet NOAH supersequences optimised for small molecule structure characterisation , 2019, Magnetic resonance in chemistry : MRC.

[3]  O. W. Sørensen,et al.  Distinguishing between two- and three-bond correlations for all 13C multiplicities in heteronuclear NMR spectroscopy. , 2018, Chemical communications.

[4]  E. Kupče,et al.  NOAH: NMR Supersequences for Small Molecule Analysis and Structure Elucidation. , 2017, Angewandte Chemie.

[5]  E. Kupče,et al.  2BOB – extracting an H2BC and an HSQC‐type spectrum from the same data set, and H2OBC – a fast experiment delineating the protonated 13C backbone , 2017, Magnetic resonance in chemistry : MRC.

[6]  V. Orekhov,et al.  Non‐uniform sampling: post‐Fourier era of NMR data collection and processing , 2015, Magnetic resonance in chemistry : MRC.

[7]  N. Nyberg,et al.  Editing of H2BC NMR spectra , 2005, Magnetic resonance in chemistry : MRC.

[8]  N. Nyberg,et al.  Heteronuclear two-bond correlation: suppressing heteronuclear three-bond or higher NMR correlations while enhancing two-bond correlations even for vanishing 2J(CH). , 2005, Journal of the American Chemical Society.

[9]  O. W. Sørensen,et al.  Economizing spectrometer time and broadband excitation in small‐molecule heteronuclear NMR correlation spectroscopy. Broadband HMBC , 2000 .

[10]  A. Bax,et al.  1H and13C Assignments from Sensitivity-Enhanced Detection of Heteronuclear Multiple-Bond Connectivity by 2D Multiple Quantum NMR , 1986 .

[11]  A. Bax,et al.  Proton and carbon-13 assignments from sensitivity-enhanced detection of heteronuclear multiple-bond connectivity by 2D multiple quantum NMR , 1986 .

[12]  R. Freeman,et al.  An excitation sequence which discriminates between direct and long-range CH coupling , 1984 .

[13]  A. Pines,et al.  Bilinear rotation decoupling of homonuclear scalar interactions , 1982 .