Dextromethorphan O-demethylase activity in rat brain microsomes
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[1] G. Tucker,et al. The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6). , 1994, Biochemical pharmacology.
[2] M. Ames,et al. Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites. , 1977, Biochemical and biophysical research communications.
[3] J. Langston,et al. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. , 1983, Science.
[4] R. Foltz,et al. Ion trap tandem mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine. , 1991, Chemical research in toxicology.
[5] P. M. Daniel,et al. Comparison of the Vascular Permeability of the Brain and the Spinal Cord to Mannitol and Inulin in Rats , 1985, Journal of neurochemistry.
[6] B. Summers,et al. Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease , 1992, The Lancet.
[7] U. Meyer,et al. MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation. , 1987, Biochemical and biophysical research communications.
[8] M. Ingelman-Sundberg,et al. Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system , 1990, Neuroscience.
[9] C. Alm,et al. Interindividual and interethnic differences in the demethylation and glucuronidation of codeine. , 1989, British journal of clinical pharmacology.
[10] T. F. Murray,et al. High affinity [3H]dextrorphan binding in rat brain is localized to a noncompetitive antagonist site of the activated N-methyl-D-aspartate receptor-cation channel. , 1992, Molecular pharmacology.
[11] J. Idle,et al. Impaired oxidation of debrisoquine in patients with perhexiline neuropathy. , 1982, British medical journal.
[12] M. Ingelman-Sundberg,et al. Different regiospecificity in the hydroxylation of the antidepressant desmethylimipramine between rat brain and liver. , 1992, Pharmacology & toxicology.
[13] G. Siest,et al. Distribution of cytochrome P450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and isolated cerebral microvessels. , 1990, Biochemical pharmacology.
[14] G. Siest,et al. Subcellular distribution of cytochrome P-450 in the brain , 1986, Brain Research.
[15] L. Bertilsson,et al. Relationship between personality and debrisoquine hydroxylation capacity , 1993, Acta psychiatrica Scandinavica.
[16] H. W. Elliott,et al. N- AND O-DEMETHYLATION OF SOME NARCOTIC ANALGESICS BY BRAIN SLICES FROM MALE AND FEMALE LONG-EVANS RATS. , 1963, Biochemical pharmacology.
[17] Peter Bjerring,et al. Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine , 1990, Clinical pharmacology and therapeutics.
[18] W. Kalow. Pharmacogenetic variability in brain and muscle. , 1994, The Journal of pharmacy and pharmacology.
[19] G. Siest,et al. Drug metabolizing enzymes in the brain and cerebral microvessels , 1991, Brain Research Reviews.
[20] O. H. Lowry,et al. Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.
[21] R. Branch,et al. Genetically determined polymorphisms in drug oxidation , 1986, Hepatology.
[22] G. Siest,et al. Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain. , 1993, Biochemical pharmacology.
[23] J. Gustafsson,et al. Cytochrome P450s of the 4A Subfamily in the Brain , 1994, Journal of neurochemistry.
[24] R. Tyndale,et al. Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. , 1991, Molecular pharmacology.