Using CorePromoter to Find Human Core Promoters

The CorePromoter program is very useful for identification of transcriptional start sites (TSS) and core promoter regions when 5′‐upstream genomic DNA sequences of human genes are available. It is very simple to use and can be accessed either through the Web or after downloading to a local computer. The protocols in this unit introduce its basic methodology and discuss how to apply it to a sample problem in conjunction with other gene‐finding programs.