Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency

[1]  J. Svendsen,et al.  Genome-wide association study identifies 18 novel loci associated with left atrial volume and function , 2021, European heart journal.

[2]  M. Olesen,et al.  Loss-of-Function Variants in the SYNPO2L Gene Are Associated With Atrial Fibrillation , 2021, Frontiers in Cardiovascular Medicine.

[3]  J. Araya,et al.  Cohort Profile. , 2020, International journal of epidemiology.

[4]  R. Kronmal,et al.  Differences by Race/Ethnicity in the Prevalence of Clinically Detected and Monitor-Detected Atrial Fibrillation , 2020, Circulation. Arrhythmia and electrophysiology.

[5]  Christopher D. Brown,et al.  The GTEx Consortium atlas of genetic regulatory effects across human tissues , 2019, Science.

[6]  A. Boyle,et al.  Predicting functional variants in enhancer and promoter elements using RegulomeDB , 2019, Human mutation.

[7]  S. Rasmussen,et al.  Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation , 2018, Nature Communications.

[8]  J. Ge,et al.  SCN5A Variants: Association With Cardiac Disorders , 2018, Front. Physiol..

[9]  P. Donnelly,et al.  The UK Biobank resource with deep phenotyping and genomic data , 2018, Nature.

[10]  Jay A. Montgomery,et al.  Multi-ethnic genome-wide association study for atrial fibrillation , 2018, Nature Genetics.

[11]  A. Wilde,et al.  Clinical Spectrum of SCN5A Mutations: Long QT Syndrome, Brugada Syndrome, and Cardiomyopathy. , 2018, JACC. Clinical electrophysiology.

[12]  Henry J. Lin,et al.  Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy , 2018, Scientific Reports.

[13]  M. Chung,et al.  Genetic Control of Left Atrial Gene Expression Yields Insights into the Genetic Susceptibility for Atrial Fibrillation , 2018, Circulation. Genomic and precision medicine.

[14]  J. Monshouwer-Kloots,et al.  Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart , 2017, PloS one.

[15]  Lars G Fritsche,et al.  Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies , 2017, Nature Genetics.

[16]  M. de Andrade,et al.  Cohort profile: the Baependi Heart Study—a family-based, highly admixed cohort study in a rural Brazilian town , 2016, BMJ Open.

[17]  T. Chao,et al.  Prognostic Significance of Premature Atrial Complexes Burden in Prediction of Long-Term Outcome , 2015, Journal of the American Heart Association.

[18]  O. Nielsen,et al.  Excessive Atrial Ectopy and Short Atrial Runs Increase the Risk of Stroke Beyond Incident Atrial Fibrillation. , 2015, Journal of the American College of Cardiology.

[19]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[20]  Eleazar Eskin,et al.  Identifying Causal Variants at Loci with Multiple Signals of Association , 2014, Genetics.

[21]  E. Vittinghoff,et al.  Atrial Ectopy as a Predictor of Incident Atrial Fibrillation , 2013, Annals of Internal Medicine.

[22]  D. Conen,et al.  Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors (GAPP). , 2013, Swiss medical weekly.

[23]  Martin Adam,et al.  Premature Atrial Contractions in the General Population: Frequency and Risk Factors , 2012, Circulation.

[24]  Eurie L. Hong,et al.  Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.

[25]  Manolis Kellis,et al.  HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants , 2011, Nucleic Acids Res..

[26]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[27]  J. Towbin,et al.  An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. , 2010, Heart rhythm.

[28]  J. Brugada,et al.  A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation. , 2008, Heart rhythm.

[29]  U. Ackermann-Liebrich,et al.  SAPALDIA: Methods and participation in the cross-sectional part of the Swiss Study on Air Pollution and Lung Diseases in Adults , 2005, Sozial- und Präventivmedizin.

[30]  R. Kronmal,et al.  Multi-Ethnic Study of Atherosclerosis: objectives and design. , 2002, American journal of epidemiology.

[31]  P. C. Viswanathan,et al.  Clinical, Genetic, and Biophysical Characterization of SCN5A Mutations Associated With Atrioventricular Conduction Block , 2002, Circulation.

[32]  K. Ueda,et al.  A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome , 2000, FEBS letters.

[33]  U Ackermann-Liebrich,et al.  Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. , 1997, American journal of respiratory and critical care medicine.

[34]  R. Kronmal,et al.  The Cardiovascular Health Study: design and rationale. , 1991, Annals of epidemiology.