EFFECTS OF LACTOGEN ON NORMAL AND ADRENALECTOMIZED FEMALE RATS

LIPSCHUTZ and Iglesias (1, 2) have reported that subserous fibroids of the uterus and of different abdominal organs, or of the abdominal wall, can be elicited in the female guinea pig by estrogens. Uterine fibroids have been reported first by Nelson (3,4), Moricard and Cauchoix(5). The findings of Lipschiits and Iglesias referring to extragenital fibroids have been corroborated and amplified by the work of Lipschutz, Vargas, Koref and others (6) in this Department, and likewise by Sammartino and Gandolfo (7), L. M. Woodruff (8) and Von Wattenwyl (9). As has been shown (10, 11), these experimental fibroids can be prevented by different steroids such as testosterone, progesterone and desoxycorticosterone. The statement that a cortical hormone can be active as an antagonist against the fibromatogenic acton of estrogens is of considerable interest. It has also been demonstrated (12, 13) that the adrenal cortex, and also desoxycorticosterone, decrease the vaginal sensitivity of castrated rats to continuous sti...