Novel enzymology in futalosine-dependent menaquinone biosynthesis.

[1]  G. Evans,et al.  Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. , 2018, ACS Chemical Biology.

[2]  M. Seyedsayamdost,et al.  Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes. , 2018, Biochemistry.

[3]  G. Evans,et al.  Immucillins in Infectious Diseases. , 2017, ACS infectious diseases.

[4]  T. Begley,et al.  Aminofutalosine Synthase (MqnE): A New Catalytic Motif in Radical SAM Enzymology. , 2018, Methods in enzymology.

[5]  K. Matsuo,et al.  Protective efficacy of a hydroxy fatty acid against gastric Helicobacter infections , 2017, Helicobacter.

[6]  D. Leys,et al.  The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN). , 2017, Archives of biochemistry and biophysics.

[7]  M. Stubbs,et al.  A Distinct Aromatic Prenyltransferase Associated with the Futalosine Pathway , 2017 .

[8]  D. Pagliarini,et al.  Biochemistry of Mitochondrial Coenzyme Q Biosynthesis. , 2017, Trends in biochemical sciences.

[9]  T. Begley,et al.  Aminofutalosine Synthase: Evidence for Captodative and Aryl Radical Intermediates Using β-Scission and SRN1 Trapping Reactions. , 2017, Journal of the American Chemical Society.

[10]  Christopher T. Walsh,et al.  Oxidative Cyclization in Natural Product Biosynthesis. , 2017, Chemical reviews.

[11]  T. Dairi,et al.  Identification of tirandamycins as specific inhibitors of the futalosine pathway , 2017, The Journal of Antibiotics.

[12]  O. Klimmek,et al.  A class C radical S‐adenosylmethionine methyltransferase synthesizes 8‐methylmenaquinone , 2017, Molecular microbiology.

[13]  Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate. , 2016, Biochemistry.

[14]  G. Evans,et al.  Neutron structures of the Helicobacter pylori 5′-methylthioadenosine nucleosidase highlight proton sharing and protonation states , 2016, Proceedings of the National Academy of Sciences.

[15]  S. Ōmura,et al.  Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. , 2016, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[16]  E. Baker,et al.  Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms. , 2016, Structure.

[17]  P. Tonge,et al.  A Methyl 4-Oxo-4-phenylbut-2-enoate with in Vivo Activity against MRSA that Inhibits MenB in the Bacterial Menaquinone Biosynthesis Pathway. , 2016, ACS infectious diseases.

[18]  J. Klinman,et al.  Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD*♦ , 2016, The Journal of Biological Chemistry.

[19]  I. Thiele,et al.  Genomic Analysis of the Human Gut Microbiome Suggests Novel Enzymes Involved in Quinone Biosynthesis , 2016, Front. Microbiol..

[20]  S. Hinrichs,et al.  Discovery of bicyclic inhibitors against menaquinone biosynthesis. , 2016, Future medicinal chemistry.

[21]  G. Evans,et al.  New Antibiotic Candidates against Helicobacter pylori. , 2015, Journal of the American Chemical Society.

[22]  Derek S. Tan,et al.  Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents. , 2015, Biochemistry.

[23]  M. Blumenberg,et al.  C35 Hopanoid Side Chain Biosynthesis: Reduction of Ribosylhopane into Bacteriohopanetetrol by a Cell‐Free System Derived from Methylobacterium organophilum , 2015, Chembiochem : a European journal of chemical biology.

[24]  Rebecca Beveridge,et al.  New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition , 2015, Nature.

[25]  Mark D. White,et al.  UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis , 2015, Nature.

[26]  M. Seyedsayamdost,et al.  Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink , 2015, Nature chemistry.

[27]  Erica L. Schwalm,et al.  Mechanistic Diversity of Radical S-Adenosylmethionine (SAM)-dependent Methylation* , 2014, The Journal of Biological Chemistry.

[28]  T. Begley,et al.  Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions* , 2014, The Journal of Biological Chemistry.

[29]  E. Takano,et al.  Ribosylhopane, a Novel Bacterial Hopanoid, as Precursor of C35 Bacteriohopanepolyols in Streptomyces coelicolor A3(2) , 2014, Chembiochem : a European journal of chemical biology.

[30]  M. Fontecave,et al.  Biosynthesis and physiology of coenzyme Q in bacteria. , 2014, Biochimica et biophysica acta.

[31]  J. Broderick,et al.  Radical S-Adenosylmethionine Enzymes , 2014, Chemical reviews.

[32]  Shukun Tang,et al.  The Futalosine Pathway Played an Important Role in Menaquinone Biosynthesis during Early Prokaryote Evolution , 2014, Genome biology and evolution.

[33]  T. Begley,et al.  Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. , 2013, Journal of the American Chemical Society.

[34]  A. Sali,et al.  Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes. , 2013, Biochemistry.

[35]  In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinone. , 2013, Biochemistry.

[36]  G. Evans,et al.  A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori. , 2012, Biochemistry.

[37]  S. Franzblau,et al.  Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis. , 2012, Journal of medicinal chemistry.

[38]  Derek S. Tan,et al.  Stable Analogues of OSB‐AMP: Potent Inhibitors of MenE, the o‐Succinylbenzoate‐CoA Synthetase from Bacterial Menaquinone Biosynthesis , 2012, Chembiochem : a European journal of chemical biology.

[39]  T. Dairi Menaquinone biosyntheses in microorganisms. , 2012, Methods in enzymology.

[40]  Carlos Simmerling,et al.  CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway. , 2011, ACS medicinal chemistry letters.

[41]  M. García-Díaz,et al.  Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member. , 2011, Biochemistry.

[42]  T. Dairi,et al.  Synthesis of (±)-cyclic dehypoxanthine futalosine, the biosynthetic intermediate in an alternative biosynthetic pathway for menaquinones , 2011 .

[43]  M. Nishiyama,et al.  Convergent strategies in biosynthesis. , 2011, Natural product reports.

[44]  H. Takami,et al.  Branched fatty acids inhibit the biosynthesis of menaquinone in Helicobacter pylori , 2011, The Journal of Antibiotics.

[45]  Nobuya Itoh,et al.  Diversity of the Early Step of the Futalosine Pathway , 2010, Antimicrobial Agents and Chemotherapy.

[46]  P. Tonge,et al.  Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. , 2010, Bioorganic & medicinal chemistry letters.

[47]  J. Kruk,et al.  Occurrence, biosynthesis and function of isoprenoid quinones. , 2010, Biochimica et biophysica acta.

[48]  R. Meganathan Menaquinone/Ubiquinone Biosynthesis and Enzymology , 2010 .

[49]  O. Kwon,et al.  Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q) , 2009, EcoSal Plus.

[50]  Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8. , 2009, Journal of structural biology.

[51]  Zhihong Guo,et al.  Catalytic mechanism of SHCHC synthase in the menaquinone biosynthesis of Escherichia coli: identification and mutational analysis of the active site residues. , 2009, Biochemistry.

[52]  T. Dairi An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains , 2009, The Journal of Antibiotics.

[53]  Joshua R. Widhalm,et al.  A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1 , 2009, Proceedings of the National Academy of Sciences.

[54]  Jun Ishikawa,et al.  An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms , 2008, Science.

[55]  T. Dairi,et al.  Studies on a new biosynthetic pathway for menaquinone. , 2008, Journal of the American Chemical Society.

[56]  A. Chatterjee,et al.  Cofactor biosynthesis--still yielding fascinating new biological chemistry. , 2008, Current opinion in chemical biology.

[57]  G. Evans,et al.  Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. , 2007, ACS chemical biology.

[58]  L. Schurgers,et al.  Vitamin K: The coagulation vitamin that became omnipotent , 2007, Thrombosis and Haemostasis.

[59]  P. Tonge,et al.  Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family. , 2007, Biochemistry.

[60]  F. Raushel,et al.  Structural and catalytic diversity within the amidohydrolase superfamily. , 2005, Biochemistry.

[61]  D. Lamson,et al.  Vitamin K2 in bone metabolism and osteoporosis. , 2005, Alternative medicine review : a journal of clinical therapeutic.

[62]  I. Rayment,et al.  Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli. , 2003, Biochemistry.

[63]  R. Rossi,et al.  Nucleophilic substitution reactions by electron transfer. , 2003, Chemical reviews.

[64]  B. Barrell,et al.  Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) , 2002, Nature.

[65]  J. Vanderleyden,et al.  A Metabolic Node in Action: Chorismate-Utilizing Enzymes in Microorganisms , 2001, Critical reviews in microbiology.

[66]  R. Meganathan Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms. , 2001, Vitamins and hormones.

[67]  I. Rayment,et al.  Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. , 2000, Biochemistry.

[68]  S. Ham,et al.  Vitamin K and energy transduction: a base strength amplification mechanism. , 1995, Science.

[69]  J. Suttie The importance of menaquinones in human nutrition. , 1995, Annual review of nutrition.

[70]  J. Chen,et al.  Fragmentation of substituted acetophenones and halobenzophenone ketyls. Calibration of a mechanistic probe , 1991 .

[71]  R. Bentley,et al.  Biosynthesis of vitamin K (menaquinone) in bacteria , 1982 .

[72]  M. J. Lindstrom,et al.  Photochemistry of .delta.-haloketones: anchimeric assistance in triplet-state .gamma.-hydrogen abstraction and .beta.-elimination of halogen atoms from the resulting diradicals , 1981 .

[73]  I. G. Young,et al.  Enzymic and nonenzymic transformations of chorismic acid and related cyclohexadienes. , 1969, Biochimica et biophysica acta.