SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter

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[53]  K. P. Lehre,et al.  The Number of Glutamate Transporter Subtype Molecules at Glutamatergic Synapses: Chemical and Stereological Quantification in Young Adult Rat Brain , 1998, The Journal of Neuroscience.

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[55]  A. Bendahan,et al.  Biotinylation of Single Cysteine Mutants of the Glutamate Transporter GLT-1 from Rat Brain Reveals Its Unusual Topology , 1998, Neuron.

[56]  A. Volterra,et al.  Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? , 1998, Trends in pharmacological sciences.

[57]  H. Horvitz,et al.  Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis , 1998, Annals of neurology.

[58]  A. Imperato,et al.  Glutamate uptake is decreased tardively in the spinal cord of FALS mice , 1998, Neuroreport.

[59]  Lin Jin,et al.  Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis , 1998, Neuron.

[60]  M. Gurney,et al.  Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis , 1998, Neurology.

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[62]  Robert H. Brown,et al.  Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis , 1997, Journal of neurochemistry.

[63]  E. Freye.  Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1 , 1997 .

[64]  A. Volterra,et al.  Differential Modulation of the Uptake Currents by Redox Interconversion of Cysteine Residues in the Human Neuronal Glutamate Transporter EAAC1 , 1997, The European journal of neuroscience.

[65]  D. Price,et al.  Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

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[67]  M. Gurney,et al.  Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[68]  D. Borchelt,et al.  ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions , 1997, Neuron.

[69]  K. P. Lehre,et al.  Brain Glutamate Transporter Proteins Form Homomultimers* , 1996, The Journal of Biological Chemistry.

[70]  M. Kavanaugh,et al.  Flux coupling in a neuronal glutamate transporter , 1996, Nature.

[71]  David W. Anderson,et al.  Altered expression of bcl‐2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons , 1996, Annals of neurology.

[72]  E. Stadtman,et al.  A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[73]  J. Rothstein,et al.  Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex , 1996, Annals of neurology.

[74]  B. Mackenzie,et al.  Amino-acid-dependent modulation of amino acid transport in Xenopus laevis oocytes. , 1996, The Journal of experimental biology.

[75]  A. Volterra,et al.  Peroxynitrite Inhibits Glutamate Transporter Subtypes (*) , 1996, The Journal of Biological Chemistry.

[76]  M. Hediger,et al.  Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate , 1996, Neuron.

[77]  D. Bredesen,et al.  Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis , 1996, Science.

[78]  P. Leigh,et al.  Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. , 1996, Lancet.

[79]  R. H. Brown.  Free radicals, programmed cell death and muscular dystrophy. , 1995, Current opinion in neurology.

[80]  A. Levey,et al.  Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis , 1995, Annals of neurology.

[81]  Andrew A. Eisen.  Amyotrophic lateral sclerosis is a multifactorial disease , 1995, Muscle & nerve.

[82]  Robert H. Brown,et al.  Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice , 1995, Cell.

[83]  D. Borchelt,et al.  Superoxide Dismutase 1 Subunits with Mutations Linked to Familial Amyotrophic Lateral Sclerosis Do Not Affect Wild-type Subunit Function (*) , 1995, The Journal of Biological Chemistry.

[84]  J. Wadiche,et al.  Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[85]  D. Borchelt,et al.  Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[86]  M. Gurney,et al.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.

[87]  V. Meininger,et al.  A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. , 1994, The New England journal of medicine.

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[89]  M. Pericak-Vance,et al.  Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. , 1993, Science.

[90]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[91]  A. Driessen,et al.  What we can learn from the effects of thiol reagents on transport proteins. , 1992, Biochimica et biophysica acta.

[92]  J. Rothstein,et al.  Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. , 1992, The New England journal of medicine.

[93]  K. Davies,et al.  Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure. , 1987, The Journal of biological chemistry.

[94]  S. W. Lin,et al.  Protein damage and degradation by oxygen radicals. II. Modification of amino acids. , 1987, The Journal of biological chemistry.

[95]  K. Davies.  Protein damage and degradation by oxygen radicals. I. general aspects. , 1987, The Journal of biological chemistry.

[96]  S. W. Lin,et al.  Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein. , 1987, The Journal of biological chemistry.