Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
暂无分享,去创建一个
B. Ebert | O. Abdel-Wahab | R. Bradley | Peter G. Smith | Stanley C Lee | A. Pastore | M. Seiler | Esther A. Obeng | J. Palacino | S. Monette | S. Buonamici | Hana Cho | Eunhee Kim | Y. R. Chung | D. Inoue | Bo Liu | Khrystyna North | A. Yoshimi | Sydney X. Lu | Justin Taylor | E. Jang | B. Durham | Sydney X Lu | Michelle Ki | Mirae Yeo | X. J. Zhang | Min Kyung Kim | Young Joon Kim | S. Lu | Stanley C. Lee
[1] M. Weirauch,et al. Correction: Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia , 2017, Nature Immunology.
[2] Gunnar Rätsch,et al. Prediction of ultra-potent shRNAs with a sequential classification algorithm , 2017, Nature Biotechnology.
[3] Jiwang Zhang,et al. Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice , 2017, Haematologica.
[4] M. Weirauch,et al. Ubiquitination of the spliceosome auxiliary factor hnRNPA1 by TRAF6 links chronic innate immune signaling with hematopoietic defects and myelodysplasia , 2016, Nature Immunology.
[5] J. Cleveland,et al. The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. , 2016, Blood.
[6] Michelle C. Chen,et al. Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation. , 2016, Cancer cell.
[7] D. Kent,et al. Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts , 2016, Leukemia.
[8] S. Armstrong,et al. Modulation of splicing catalysis for therapeutic targeting of leukemias with spliceosomal mutations , 2016, Nature Medicine.
[9] M. Warmuth,et al. Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point. , 2015, Cell reports.
[10] A. Karsan,et al. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling , 2015, The Journal of experimental medicine.
[11] Alexander V Penson,et al. Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities , 2015, Proceedings of the National Academy of Sciences.
[12] H. Deeg,et al. SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition. , 2015, Cancer cell.
[13] A. Derti,et al. A chemical genetics approach for the functional assessment of novel cancer genes. , 2015, Cancer research.
[14] Dennis Carson,et al. Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers , 2015, PLoS Comput. Biol..
[15] Raphael Gottardo,et al. Orchestrating high-throughput genomic analysis with Bioconductor , 2015, Nature Methods.
[16] M Cazzola,et al. Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells , 2014, Leukemia.
[17] H. Dvinge,et al. Sample processing obscures cancer-specific alterations in leukemic transcriptomes , 2014, Proceedings of the National Academy of Sciences.
[18] M. Weirauch,et al. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network. , 2014, Cell reports.
[19] D. Starczynowski. Errant innate immune signaling in del(5q) MDS. , 2014, Blood.
[20] Philip Bradley,et al. U2AF1 mutations alter splice site recognition in hematological malignancies , 2014, bioRxiv.
[21] Christof Fellmann,et al. An optimized microRNA backbone for effective single-copy RNAi. , 2013, Cell reports.
[22] M. Stratton,et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. , 2013, Blood.
[23] C Haferlach,et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes , 2013, Leukemia.
[24] D. Neuberg,et al. Toll-like receptor alterations in myelodysplastic syndrome , 2013, Leukemia.
[25] A. Hinnebusch,et al. Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3 , 2013, Nature Genetics.
[26] T. Graf,et al. CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age. , 2013, Blood.
[27] Emily J. Girard,et al. Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A , 2013 .
[28] A. M. de Bruin,et al. In Vivo Knockdown of TAK1 Accelerates Bone Marrow Proliferation/Differentiation and Induces Systemic Inflammation , 2013, PloS one.
[29] A. Tefferi,et al. Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: Prevalence, clinical correlates, and prognostic relevance , 2013, American journal of hematology.
[30] Ying Zhao,et al. Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice , 2013, PloS one.
[31] A. Bowcock,et al. Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma , 2013, Nature Genetics.
[32] Michael D. Schneider,et al. Deletion of TAK1 in the Myeloid Lineage Results in the Spontaneous Development of Myelomonocytic Leukemia in Mice , 2012, PloS one.
[33] Laurent Gil,et al. Ensembl 2013 , 2012, Nucleic Acids Res..
[34] Brian T. Lee,et al. The UCSC Genome Browser database: extensions and updates 2013. , 2012, Nucleic acids research.
[35] A. Tefferi,et al. SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival. , 2012, Blood.
[36] S. Ogawa,et al. SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML). , 2012, Blood.
[37] D. Neuberg,et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[38] M. Gönen,et al. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. , 2012, Blood.
[39] Michael Heuser,et al. Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. , 2012, Blood.
[40] A. Jankowska,et al. Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. , 2012, Blood.
[41] Claude Preudhomme,et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. , 2012, Blood.
[42] D. Stupack,et al. Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules , 2012, Apoptosis.
[43] G. Kollias,et al. Myeloid Takl Acts as a Negative Regulator of the LPS Response and Mediates Resistance to Endotoxemia , 2012, PloS one.
[44] B. Su,et al. TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils. , 2012, Immunity.
[45] A. Sivachenko,et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. , 2011, The New England journal of medicine.
[46] Mary Goldman,et al. The UCSC Genome Browser database: extensions and updates 2011 , 2011, Nucleic Acids Res..
[47] M. Stratton,et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. , 2011, The New England journal of medicine.
[48] S. Sugano,et al. Frequent pathway mutations of splicing machinery in myelodysplasia , 2011, Nature.
[49] Colin N. Dewey,et al. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome , 2011, BMC Bioinformatics.
[50] L. Nie,et al. Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells , 2011, The Journal of Immunology.
[51] Eric T. Wang,et al. Analysis and design of RNA sequencing experiments for identifying isoform regulation , 2010, Nature Methods.
[52] Peter A. C. 't Hoen,et al. mRNA degradation controls differentiation state-dependent differences in transcript and splice variant abundance , 2010, Nucleic Acids Res..
[53] E. Wagenmakers,et al. Bayesian hypothesis testing for psychologists: A tutorial on the Savage–Dickey method , 2010, Cognitive Psychology.
[54] M. Robinson,et al. A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.
[55] Matthew D. Young,et al. Gene ontology analysis for RNA-seq: accounting for selection bias , 2010, Genome Biology.
[56] Q. Rao,et al. A New Caspase-8 Isoform Caspase-8s Increased Sensitivity to Apoptosis in Jurkat Cells , 2010, Journal of biomedicine & biotechnology.
[57] Cole Trapnell,et al. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.
[58] S. Akira,et al. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice , 2008, The Journal of experimental medicine.
[59] Mark J. Murphy,et al. Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. , 2008, Cell stem cell.
[60] Lina A. Thoren,et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. , 2007, Cell stem cell.
[61] T. Suda,et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. , 2007, Cell stem cell.
[62] S. Akira,et al. Essential function for the kinase TAK1 in innate and adaptive immune responses , 2005, Nature Immunology.
[63] T. Miyashita,et al. Caspase‐8 and caspase‐10 activate NF‐κB through RIP, NIK and IKKα kinases , 2003 .
[64] L. Hood,et al. Activation of the NF-κB pathway by Caspase 8 and its homologs , 2000, Oncogene.
[65] H. Shu,et al. Activation of NF-κB by FADD, Casper, and Caspase-8* , 2000, The Journal of Biological Chemistry.
[66] D. Goeddel,et al. Casper is a FADD- and caspase-related inducer of apoptosis. , 1997, Immunity.
[67] J. Tschopp,et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors , 1997, Nature.
[68] W S Alexander,et al. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. , 1996, Blood.
[69] Lior Pachter,et al. Sequence Analysis , 2020, Definitions.