Double functionalization of carbon nanotubes for multimodal drug delivery.

Multi-walled carbon nanotubes have been covalently functionalized via 1,3-dipolar cycloaddition of azomethine ylides with orthogonally protected amino functions that can be selectively deprotected and subsequently modified with drugs and fluorescent probes.

[1]  M. Prato,et al.  Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes. , 2005, Angewandte Chemie.

[2]  Zhuang Liu,et al.  Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. , 2005, Journal of the American Chemical Society.

[3]  H. Dai,et al.  Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4]  M. Prato,et al.  Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. , 2005, Journal of the American Chemical Society.

[5]  M. Ferrari Cancer nanotechnology: opportunities and challenges , 2005, Nature Reviews Cancer.

[6]  H. Dai,et al.  Carbon nanotubes as intracellular protein transporters: generality and biological functionality. , 2005, Journal of the American Chemical Society.

[7]  M. Prato,et al.  Biomedical applications of functionalised carbon nanotubes. , 2005, Chemical communications.

[8]  Maurizio Prato,et al.  Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties. , 2005, Journal of the American Chemical Society.

[9]  M. Prato,et al.  Carbon nanotube-mediated delivery of peptides and genes to cells: translating nanobiotechnology to therapeutics , 2005 .

[10]  M. Prato,et al.  Translocation of bioactive peptides across cell membranes by carbon nanotubes. , 2004, Chemical communications.

[11]  Alberto Bianco,et al.  Carbon nanotubes for the delivery of therapeutic molecules , 2004, Expert opinion on drug delivery.

[12]  M. Prato,et al.  Functionalized carbon nanotubes for plasmid DNA gene delivery. , 2004, Angewandte Chemie.

[13]  C. Di Giacomo,et al.  Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling. , 2004, Bioorganic & medicinal chemistry.

[14]  H. Dai,et al.  Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. , 2004, Journal of the American Chemical Society.

[15]  James M Tour,et al.  Overcoming the insolubility of carbon nanotubes through high degrees of sidewall functionalization. , 2004, Chemistry.

[16]  Wei Wang,et al.  Advances toward bioapplications of carbon nanotubes , 2004 .

[17]  Thommey P. Thomas,et al.  Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor , 2002, Pharmaceutical Research.

[18]  J. Bradbury Beyond pills and jabs , 2003, The Lancet.

[19]  M. Prato,et al.  Can Carbon Nanotubes be Considered Useful Tools for Biological Applications? , 2003 .

[20]  Maurizio Prato,et al.  Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. , 2003, Chemistry & biology.

[21]  M. Prato,et al.  Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides. , 2003, Journal of the American Chemical Society.

[22]  C. R. Martin,et al.  The emerging field of nanotube biotechnology , 2003, Nature Reviews Drug Discovery.

[23]  M. Prato,et al.  Amino acid functionalisation of water soluble carbon nanotubes. , 2002, Chemical communications.

[24]  A. Hirsch Functionalization of single-walled carbon nanotubes. , 2002, Angewandte Chemie.

[25]  M. Prato,et al.  Organic functionalization of carbon nanotubes. , 2002, Journal of the American Chemical Society.

[26]  A. Schally,et al.  Selective coupling of methotrexate to peptide hormone carriers through a gamma-carboxamide linkage of its glutamic acid moiety: benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate activation in salt coupling. , 1993, Proceedings of the National Academy of Sciences of the United States of America.