Dissociation between declarative and procedural learning in dementia and depression.

Declarative and procedural learning were assessed in patients with probable Alzheimer's Disease (AD) and major depression, patients with AD and no depression, patients with major depression but no dementia, and a group of age-comparable nondemented and nondepressed normal controls. AD patients showed significant deficits in declarative but not in procedural learning, while depressed nondemented patients showed the opposite pattern (i.e., a significantly worse procedural than declarative learning). Patients with both AD and major depression showed a similar learning pattern to the AD nondepressed group (relatively preserved procedural learning but severe deficits in declarative memory). These findings provide further evidence for the independence between declarative and procedural learning, and demonstrate their different vulnerability in dementia and depressive-like states.

[1]  R. Post,et al.  Effortful and automatic cognitive processes in depression. , 1986, Archives of general psychiatry.

[2]  M. Nissen,et al.  Implicit learning in patients with probable Alzheimer's disease , 1987, Neurology.

[3]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[4]  D. Schacter,et al.  Implicit and explicit memory for new associations in normal and amnesic subjects. , 1985, Journal of experimental psychology. Learning, memory, and cognition.

[5]  R. Bornstein,et al.  Depression and memory in major depressive disorder. , 1991, The Journal of neuropsychiatry and clinical neurosciences.

[6]  N. Pomara,et al.  Aging, emotional states, and memory. , 1993, The American journal of psychiatry.

[7]  M. First,et al.  The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description. , 1992, Archives of general psychiatry.

[8]  O L Lopez,et al.  Awareness of cognitive deficits and anosognosia in probable Alzheimer's disease. , 1994, European neurology.

[9]  J. Becker,et al.  Alzheimer's disease and depression: neuropsychological impairment and progression of the illness. , 1990, The American journal of psychiatry.

[10]  A R Damasio,et al.  Preserved motor learning in Alzheimer's disease: implications for anatomy and behavior , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[11]  J Marshall,et al.  Cerebral blood flow in dementia. , 1975, Archives of neurology.

[12]  J. Danion,et al.  Explicit memory and repetition priming in depression. Preliminary findings. , 1991, Archives of general psychiatry.

[13]  R. Hamer,et al.  Digit symbol performance in mild dementia and depression. , 1987, Journal of consulting and clinical psychology.

[14]  J. Moossy,et al.  Major depression in primary dementia. Clinical and neuropathologic correlates. , 1988, Archives of neurology.

[15]  HERMAN BUSCHKE,et al.  Evaluating storage, retention, and retrieval in disordered memory and learning , 1974, Neurology.

[16]  L. Bieliauskas.  Depressed or not depressed? that is the question , 1993 .

[17]  D. Salmon,et al.  Neuropsychological evidence for multiple implicit memory systems: a comparison of Alzheimer's, Huntington's, and Parkinson's disease patients , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[18]  R. Robinson,et al.  Depression in neurologic disease , 1993 .

[19]  D. Price,et al.  The neuropathology of aminergic nuclei in Alzheimer's disease , 1988, Progress in clinical and biological research.

[20]  H. Buschke,et al.  Implicit and explicit memory in young, old, and demented adults. , 1992, Journal of clinical and experimental neuropsychology.

[21]  M. Hamilton.  A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[22]  S. Kugelmass,et al.  Verbal and non-verbal recall by depressed and euthymic affective patients , 1986, Psychological Medicine.

[23]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[24]  R. Wilson,et al.  Maze learning in Alzheimer's disease , 1991, Brain and Cognition.

[25]  S. Starkstein,et al.  Quantified electroencephalographic changes in depressed patients with and without dementia , 1995, Biological Psychiatry.