论文信息 - A Class of Designs for Sequential Clinical Trials

A Class of Designs for Sequential Clinical Trials

Abstract In a situation comparing the effectiveness of two clinical treatments, eligible subjects come to an experimental site sequentially and must be treated at once. In order to reduce different kinds of experimental bias and also increase the precision of inferences about treatment effects, a class of designs which offers a compromise between perfect balance and complete randomization is proposed and analyzed in this article. These new designs have the desirable property of forcing a small-sized experiment to be balanced while tending toward a complete randomization scheme as the size of the experiment increases.

Lee-Jen Wei | L. J. Wei

[1] Hill Ab,et al. The clinical trial. , 1952 .

[2] J. L. Hodges,et al. Design for the Control of Selection Bias , 1957 .

[3] Stephen M. Stigler. The use of random allocation for the control of selection bias , 1969 .

[4] R. A. Fisher,et al. Design of Experiments , 1936 .

[5] M Zelen,et al. The randomization and stratification of patients to clinical trials. , 1974, Journal of chronic diseases.

[6] B. Friedman,et al. A simple urn model , 1949 .

[7] L. J. Wei,et al. The Adaptive Biased Coin Design for Sequential Experiments , 1978 .

[8] S. Pocock,et al. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. , 1975, Biometrics.

[9] D. Freedman. Bernard Friedman's Urn , 1965 .

[10] Alvan R. Feinstein,et al. XIV. The purposes of prognostic stratification , 1972 .

[11] E. Lehmann,et al. Testing Statistical Hypothesis. , 1960 .

[12] B. Efron. Forcing a sequential experiment to be balanced , 1971 .

[13] P. Armitage. Sequential Medical Trials , 1961, Biomedicine / [publiee pour l'A.A.I.C.I.G.].