Pertussis (Whooping Cough)

Abstract Pertussis (whooping cough) is a respiratory infection caused by Bordetella pertussis. All ages are susceptible. In the prevaccine era, almost all children became infected. Pertussis is particularly dangerous in young infants, who account for practically all hospitalizations and deaths, but clinical disease is burdensome at any age. Widespread use of pertussis vaccines dramatically reduced cases, but concern over adverse reactions led to the replacement of standard whole-cell by acellular pertussis vaccines that contain only a few selected pertussis antigens and are far less reactogenic. Routine administration of acellular pertussis vaccines combined with diphtheria and tetanus toxoids is recommended in infancy with toddler and preschool boosters, at age 11, and during pregnancy. Boosting in the second half of every pregancy is critical to protection of the newborn. Waning of vaccine immunity over time has become an increasing concern, and several new pertussis vaccines are being evaluated to address this problem.

[1]  E. Lewis,et al.  Acellular Pertussis Vaccine Effectiveness Over Time , 2019, Pediatrics.

[2]  S. Plotkin.  Composition of pertussis vaccine given to infants determines long-term T cell polarization , 2018, The Journal of clinical investigation.

[3]  B. Pulendran,et al.  Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters , 2018, The Journal of clinical investigation.

[4]  T. Skoff,et al.  Impact of the US Maternal Tetanus, Diphtheria, and Acellular Pertussis Vaccination Program on Preventing Pertussis in Infants <2 Months of Age: A Case-Control Evaluation , 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  T. Merkel,et al.  Pertussis disease and transmission and host responses: insights from the baboon model of pertussis. , 2017, The Journal of infection.

[6]  Anna M. Acosta,et al.  Tdap Vaccine Effectiveness in Adolescents During the 2012 Washington State Pertussis Epidemic , 2015, Pediatrics.

[7]  T. Merkel,et al.  Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model , 2013, Proceedings of the National Academy of Sciences.

[8]  C. Locht,et al.  New pertussis vaccination approaches: en route to protect newborns? , 2012, FEMS immunology and medical microbiology.

[9]  Robert S Ware,et al.  Number and order of whole cell pertussis vaccines in infancy and disease protection. , 2012, JAMA.

[10]  M. Brennan,et al.  Changing epidemiology of pertussis in the United States: increasing reported incidence among adolescents and adults, 1990-1996. , 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  M. Pichichero,et al.  Comparison of 13 acellular pertussis vaccines: overview and serologic response. , 1995, Pediatrics.

[12]  M. Pichichero,et al.  Comparison of 13 acellular pertussis vaccines: adverse reactions. , 1993, Pediatrics.

[13]  H. Fineberg,et al.  Adverse events following pertussis and rubella vaccines. Summary of a report of the Institute of Medicine. , 1992, JAMA.

[14]  Nancy E. Messonnier,et al.  Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP). , 2018, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[15]  A. Jindal,et al.  Pertussis vaccine , 2012, Reactions Weekly.