Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells

[1]  J. Yu,et al.  Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches , 2017, Oncogene.

[2]  Xiaobing Shi,et al.  LSD1 binds to HPV16 E7 and promotes the epithelial-mesenchymal transition in cervical cancer by demethylating histones at the Vimentin promoter , 2016, Oncotarget.

[3]  Mishal N. Patel,et al.  British Society of Breast Radiology Annual Scientific Meeting 2016 , 2016, Breast Cancer Research.

[4]  F. Sotgia,et al.  Cancer stem cell metabolism , 2016, Breast Cancer Research.

[5]  H. Matsui,et al.  A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells , 2016, Scientific Reports.

[6]  K. Machida,et al.  NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism. , 2016, Cell metabolism.

[7]  J. Yates,et al.  Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth. , 2015, Developmental cell.

[8]  Z. Weng,et al.  The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential. , 2015, Cancer cell.

[9]  M. Pappalardi,et al.  A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. , 2015, Cancer cell.

[10]  Yau-Huei Wei,et al.  Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma , 2015, Cell cycle.

[11]  H. Ishii,et al.  Visualization and characterization of cancer stem-like cells in cervical cancer. , 2014, International journal of oncology.

[12]  H. Ishii,et al.  Identification of chemoradiation-resistant osteosarcoma stem cells using an imaging system for proteasome activity. , 2014, International journal of oncology.

[13]  J. Long,et al.  LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process. , 2014, Cancer letters.

[14]  A. Krešo,et al.  Evolution of the cancer stem cell model. , 2014, Cell stem cell.

[15]  A. Iavarone,et al.  The ID proteins: master regulators of cancer stem cells and tumour aggressiveness , 2014, Nature Reviews Cancer.

[16]  Hong Sun,et al.  LSD1 Regulates Pluripotency of Embryonic Stem/Carcinoma Cells through Histone Deacetylase 1-Mediated Deacetylation of Histone H4 at Lysine 16 , 2013, Molecular and Cellular Biology.

[17]  J. Locasale Serine, glycine and one-carbon units: cancer metabolism in full circle , 2013, Nature Reviews Cancer.

[18]  Simon Kasif,et al.  An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. , 2013, Cell reports.

[19]  J. Wysocka,et al.  Modification of enhancer chromatin: what, how, and why? , 2013, Molecular cell.

[20]  J. Issa,et al.  The epigenome of AML stem and progenitor cells , 2013, Epigenetics.

[21]  S. Arii,et al.  Identification of pancreatic cancer stem cells and selective toxicity of chemotherapeutic agents. , 2012, Gastroenterology.

[22]  A. Krešo,et al.  ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. , 2012, Cancer cell.

[23]  T. Lv,et al.  Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer , 2012, PloS one.

[24]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[25]  S. Merali,et al.  Polyamine-Regulated Translation of Spermidine/Spermine-N1-Acetyltransferase , 2012, Molecular and Cellular Biology.

[26]  Helga Thorvaldsdóttir,et al.  Integrative Genomics Viewer , 2011, Nature Biotechnology.

[27]  D. Geerts,et al.  The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification , 2010, International journal of cancer.

[28]  J. Sayre,et al.  In vivo imaging, tracking, and targeting of cancer stem cells. , 2009, Journal of the National Cancer Institute.

[29]  R. Versteeg,et al.  Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. , 2009, Cancer research.

[30]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[31]  S. Baylin,et al.  Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes , 2007, Proceedings of the National Academy of Sciences.

[32]  R. Schüle,et al.  Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. , 2006, Cancer research.

[33]  Matthew P. Repasky,et al.  Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. , 2006, Journal of medicinal chemistry.

[34]  Yong Chen,et al.  Crystal structure of human histone lysine-specific demethylase 1 (LSD1) , 2006, Proceedings of the National Academy of Sciences.

[35]  André Hoelz,et al.  Crystal structure and mechanism of human lysine-specific demethylase-1 , 2006, Nature Structural &Molecular Biology.

[36]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[37]  M. Takamura,et al.  Overexpressed Id‐1 is associated with a high risk of hepatocellular carcinoma development in patients with cirrhosis without transcriptional repression of p16 , 2005, Cancer.

[38]  Andy J. Minn,et al.  Genes that mediate breast cancer metastasis to lung , 2005, Nature.

[39]  Yang Shi,et al.  Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 , 2004, Cell.

[40]  E. Gerner,et al.  Polyamines and cancer: old molecules, new understanding , 2004, Nature Reviews Cancer.

[41]  B. Honig,et al.  A hierarchical approach to all‐atom protein loop prediction , 2004, Proteins.

[42]  Y. Itahana,et al.  Id-1 and Id-2 Proteins as Molecular Markers for Human Prostate Cancer Progression , 2004, Clinical Cancer Research.

[43]  P. Coffino Ubiquitin and proteasomes: Regulation of cellular polyamines by antizyme , 2001, Nature Reviews Molecular Cell Biology.

[44]  S. Gilmour,et al.  High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation , 2000, Journal of cellular biochemistry.

[45]  P. Gimotty,et al.  Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[46]  S. Matsufuji,et al.  Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination , 1992, Nature.

[47]  Hiroshi Kobayashi,et al.  Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver. , 1991, The Journal of biological chemistry.