Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend.

Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV-VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations.

[1]  S. Stavchansky,et al.  Electrostatic spraying and its use in drug delivery — Cholesterol microspheres , 1995 .

[2]  R. Jerome,et al.  Microencapsulation by coacervation of poly(lactide-co-glycolide). IV. Effect of the processing parameters on coacervation and encapsulation , 1995 .

[3]  David G Simpson,et al.  Electrospinning of collagen nanofibers. , 2002, Biomacromolecules.

[4]  R. Langer,et al.  Polymers for the sustained release of proteins and other macromolecules , 1976, Nature.

[5]  D. Reneker,et al.  Nanometre diameter fibres of polymer, produced by electrospinning , 1996 .

[6]  M. Cugini,et al.  Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers. , 1990, Journal of periodontal research.

[7]  R. Langer,et al.  Biodegradable polymers as drug delivery systems , 1990 .

[8]  J D Stitzel,et al.  Arterial Smooth Muscle Cell Proliferation on a Novel Biomimicking, Biodegradable Vascular Graft Scaffold , 2001, Journal of biomaterials applications.

[9]  Donald L. Wise,et al.  Handbook of Pharmaceutical Controlled Release Technology , 2000 .

[10]  Elliot L. Chaikof,et al.  Generation of Synthetic Elastin-Mimetic Small Diameter Fibers and Fiber Networks , 2000 .

[11]  David C. Martin,et al.  Processing and microstructural characterization of porous biocompatible protein polymer thin films , 1999 .

[12]  M. Goosen,et al.  An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made using electrostatics , 1997 .

[13]  R. Bettini.  Biomaterials for drug and cell delivery: A.G. Mikos, R.M. Murphy, H. Bernstein and N.A. Peppas (Eds.), Material Research Society, Pittsburgh, 1994, 290 pp., $ 78 , 1995 .

[14]  R L Dunn,et al.  Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets. , 1983, Journal of periodontology.

[15]  Darrell H. Reneker,et al.  Bending instability of electrically charged liquid jets of polymer solutions in electrospinning , 2000 .

[16]  J. Deitzel,et al.  The effect of processing variables on the morphology of electrospun nanofibers and textiles , 2001 .

[17]  G. Wnek,et al.  Electrospraying and electrospinning of polymers for biomedical applications. Poly(lactic-co-glycolic acid) and poly(ethylene-co-vinylacetate) , 2000 .