Prevalence and Severity of Coronary Artery Disease and Adverse Events Among Symptomatic Patients With Coronary Artery Calcification Scores of Zero Undergoing Coronary Computed Tomography Angiography

Todd C. Villines, MD,* Edward A. Hulten, MD, MPH,* Leslee J. Shaw, PHD,† Manju Goyal, MD,* Allison Dunning, MS,‡ Stephan Achenbach, MD,§ Mouaz Al-Mallah, MD, MSC, Daniel S. Berman, MD,¶ Matthew J. Budoff, MD,# Filippo Cademartiri, MD, PHD,** Tracy Q. Callister, MD,†† Hyuk-Jae Chang, MD, PHD,‡‡ Victor Y. Cheng, MD,¶ Kavitha Chinnaiyan, MD,§§ Benjamin J. W. Chow, MD, Augustin Delago, MD,¶¶ Martin Hadamitzky, MD,## Jörg Hausleiter, MD,## Philipp Kaufmann, MD,*** Fay Y. Lin, MD,††† Erica Maffei, MD,** Gilbert L. Raff, MD,§§ James K. Min, MD,‡‡‡ for the CONFIRM Registry Investigators Bethesda, Maryland; Atlanta, Georgia; Albany and New York, New York; Giessen, Germany; Detroit and Royal Oaks, Michigan; Los Angeles, California; Parma, Italy; Rotterdam, the Netherlands; Hendersonville, Tennessee; Seoul Korea; Ottawa, Ontario, Canada; Munich, Germany; and Zurich, Switzerland

[1]  M. Pencina,et al.  Rationale and design of the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) Registry. , 2011, Journal of cardiovascular computed tomography.

[2]  M. Budoff,et al.  2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults: Executive Summary , 2010 .

[3]  P. Greenland,et al.  Coronary artery calcium score and risk classification for coronary heart disease prediction. , 2010, JAMA.

[4]  Ilan Gottlieb,et al.  The absence of coronary calcification does not exclude obstructive coronary artery disease or the need for revascularization in patients referred for conventional coronary angiography. , 2010, Journal of the American College of Cardiology.

[5]  S. Abbara SCCT guidelines for performance of coronary computed tomographic angiography: A report of the Society of Cardiovascular Computed Tomography Guidelines Committee , 2010 .

[6]  Hirofumi Anno,et al.  Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome. , 2009, Journal of the American College of Cardiology.

[7]  Udo Hoffmann,et al.  Diagnostic and prognostic value of absence of coronary artery calcification. , 2009, JACC. Cardiovascular imaging.

[8]  D. Berman,et al.  Absence of coronary artery calcification and all-cause mortality. , 2009, JACC. Cardiovascular imaging.

[9]  Jörg Hausleiter,et al.  Prognostic value of coronary computed tomographic angiography for prediction of cardiac events in patients with suspected coronary artery disease. , 2009, JACC. Cardiovascular imaging.

[10]  S. King,et al.  Influence of symptomatic status on the prevalence of obstructive coronary artery disease in patients with zero calcium score. , 2009, Atherosclerosis.

[11]  D. Berman,et al.  SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography. , 2009, Journal of cardiovascular computed tomography.

[12]  Chiara Martini,et al.  Diagnostic accuracy of computed tomography coronary angiography in patients with a zero calcium score , 2009, European Radiology.

[13]  Jeroen J. Bax,et al.  Noninvasive evaluation with multislice computed tomography in suspected acute coronary syndrome: plaque morphology on multislice computed tomography versus coronary calcium score. , 2008, Journal of the American College of Cardiology.

[14]  B. Lewis,et al.  Prevalence and extent of obstructive coronary artery disease in patients with zero or low calcium score undergoing 64-slice cardiac multidetector computed tomography for evaluation of a chest pain syndrome. , 2007, The American journal of cardiology.

[15]  Mark A. Hlatky,et al.  ACCF/AHA 2007 Clinical Expert Consensus Document on Coronary Artery Calcium Scoring By Computed Tomography in Global Cardiovascular Risk Assessment and in Evaluation of Patients With Chest Pain , 2007 .

[16]  P. Steinbigler,et al.  Multislice spiral computed tomographic angiography of coronary arteries in patients with suspected coronary artery disease: an effective filter before catheter angiography? , 2005, American heart journal.

[17]  W. Edwards,et al.  Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology. , 1998, Journal of the American College of Cardiology.

[18]  A. Morise,et al.  Development and validation of a clinical score to estimate the probability of coronary artery disease in men and women presenting with suspected coronary disease. , 1997, The American journal of medicine.

[19]  R. Detrano,et al.  Quantification of coronary artery calcium using ultrafast computed tomography. , 1990, Journal of the American College of Cardiology.

[20]  E. DeLong,et al.  Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. , 1988, Biometrics.

[21]  G. Diamond,et al.  Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. , 1979, The New England journal of medicine.