DNA Methylation Changes during In Vitro Propagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability?
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M. Miloso | G. Tredici | L. Dalprà | A. Bentivegna | G. Riva | D. Foudah | V. Butta
[1] T. Ye,et al. Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells , 2013, Journal of cellular biochemistry.
[2] Seok-Goo Cho,et al. Clinical applications of mesenchymal stem cells , 2013, The Korean journal of internal medicine.
[3] Manuel Serrano,et al. The Hallmarks of Aging , 2013, Cell.
[4] Kirsten R. McEwen,et al. The impact of culture on epigenetic properties of pluripotent stem cells and pre-implantation embryos. , 2013, Biochemical Society transactions.
[5] L. Bouzas,et al. Stability of human mesenchymal stem cells during in vitro culture: considerations for cell therapy , 2013, Cell proliferation.
[6] W. Wagner. Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation? , 2012, Stem Cell Research & Therapy.
[7] D. Yamaguchi,et al. Constitutive Expression of Human Telomerase Enhances the Proliferation Potential of Human Mesenchymal Stem Cells , 2012, BioResearch open access.
[8] M. Miloso,et al. From cytogenomic to epigenomic profiles: monitoring the biologic behavior of in vitro cultured human bone marrow mesenchymal stem cells , 2012, Stem Cell Research & Therapy.
[9] Jin Choul Chai,et al. Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture , 2012, Experimental & Molecular Medicine.
[10] Leping Li,et al. Development of bone marrow mesenchymal stem cell culture in vitro. , 2012, Chinese medical journal.
[11] M. Zenke,et al. Monitoring of cellular senescence by DNA‐methylation at specific CpG sites , 2012, Aging cell.
[12] F. Locatelli,et al. Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine? , 2012, Bone Marrow Transplantation.
[13] W. Khan,et al. Optimising Human Mesenchymal Stem Cell Numbers for Clinical Application: A Literature Review , 2012, Stem cells international.
[14] Tomoaki Tanaka,et al. Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions , 2011, Journal of cellular and molecular medicine.
[15] M. Esteller,et al. DNA methylation in stem cell renewal and multipotency , 2011, Stem Cell Research & Therapy.
[16] Wolfgang Wagner,et al. Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks , 2011, Aging.
[17] Huey-Kang Sytwu,et al. Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells , 2011, Journal of Biomedical Science.
[18] T. He,et al. Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation , 2011, Stem cells international.
[19] Yaojiong Wu,et al. Epigenetic Dysregulation in Mesenchymal Stem Cell Aging and Spontaneous Differentiation , 2011, PLoS ONE.
[20] M. Shi,et al. Immunomodulatory properties and therapeutic application of mesenchymal stem cells , 2011, Clinical and experimental immunology.
[21] Natalia de Isla,et al. Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status , 2011, BMC Cell Biology.
[22] C. Herberts,et al. Risk factors in the development of stem cell therapy , 2011, Journal of Translational Medicine.
[23] S. Welford,et al. Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression , 2011, Molecular Cancer Research.
[24] A. Cometa,et al. Ex vivo expansion of mesenchymal stromal cells. , 2011, Best practice & research. Clinical haematology.
[25] Xiao-bing Fu,et al. MSCs: Biological characteristics, clinical applications and their outstanding concerns , 2011, Ageing Research Reviews.
[26] C. Chiu,et al. Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST. , 2011, Blood.
[27] B. Tannous,et al. miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis , 2010, Oncotarget.
[28] M. Esteller,et al. Aberrant epigenetic landscape in cancer: how cellular identity goes awry. , 2010, Developmental cell.
[29] P. Collas. Programming differentiation potential in mesenchymal stem cells , 2010, Epigenetics.
[30] J. Cigudosa,et al. Retraction: Spontaneous human adult stem cell transformation. , 2010, Cancer research.
[31] R. Bjerkvig,et al. Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track - letter. , 2010, Cancer research.
[32] Sterling Thomas,et al. A survey of current software for network analysis in molecular biology , 2010, Human Genomics.
[33] J. Cigudosa,et al. Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells. , 2010, Experimental cell research.
[34] Lee E. Edsall,et al. Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. , 2010, Cell stem cell.
[35] Wolfgang Wagner,et al. Different facets of aging in human mesenchymal stem cells. , 2010, Tissue engineering. Part B, Reviews.
[36] Wolfgang Wagner,et al. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. , 2010, Genome research.
[37] Carmen Koch,et al. How to track cellular aging of mesenchymal stromal cells? , 2010, Aging.
[38] D. Brash,et al. Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair , 2010, PLoS genetics.
[39] Young-ho Kim. Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase , 2010 .
[40] Hélène Rouard,et al. Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation. , 2010, Blood.
[41] B. Korn,et al. DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells , 2010, Aging cell.
[42] M. Miloso,et al. Monitoring the genomic stability of in vitro cultured rat bone-marrow-derived mesenchymal stem cells , 2009, Chromosome Research.
[43] T. de Lange. How Telomeres Solve the End-Protection Problem , 2009, Science.
[44] S. Gronthos,et al. Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine , 2009, Journal of dental research.
[45] Jianhua Guo,et al. Genome-Wide Analysis of Histone H3 Lysine9 Modifications in Human Mesenchymal Stem Cell Osteogenic Differentiation , 2009, PloS one.
[46] A. Borkhardt,et al. Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2 , 2009, Cell cycle.
[47] P. Lønning,et al. Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. , 2009, Cancer research.
[48] Wolfgang Wagner,et al. Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells , 2009, PloS one.
[49] E. Hara,et al. Cellular senescence: Its role in tumor suppression and aging , 2009, Cancer science.
[50] K. Friedman,et al. Chromosome End Maintenance by Telomerase* , 2009, The Journal of Biological Chemistry.
[51] Ren-Ke Li,et al. A Transformed Cell Population Derived from Cultured Mesenchymal Stem Cells has no Functional Effect after Transplantation into the Injured Heart , 2009, Cell transplantation.
[52] J. Blanco,et al. Optimization of mesenchymal stem cell expansion procedures by cell separation and culture conditions modification. , 2008, Experimental hematology.
[53] V. Moreno-Manzano,et al. Hypoxia Causes Downregulation of Mismatch Repair System and Genomic Instability in Stem Cells , 2008, Stem cells.
[54] D. Kaushal,et al. Long-term in vitro expansion alters the biology of adult mesenchymal stem cells. , 2008, Cancer research.
[55] V. Beneš,et al. Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process , 2008, PloS one.
[56] S. Lehmann,et al. Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials. , 2008, Experimental cell research.
[57] P. Lansdorp. Telomeres, stem cells, and hematology. , 2008, Blood.
[58] A. Cometa,et al. Human Bone Marrow-Derived Mesenchymal Stem Cells Do Not Undergo Transformation after Long-Term In Vitro Culture and Do Not Exhibit Telomere Maintenance Mechanisms. , 2007 .
[59] D. S. Perez,et al. Non-random inactivation of large common fragile site genes in different cancers , 2007, Cytogenetic and Genome Research.
[60] Feng Zhao,et al. Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. , 2007, Biochemical and biophysical research communications.
[61] Zhe Wang,et al. Cytogenetic analysis of human bone marrow‐derived mesenchymal stem cells passaged in vitro , 2007, Cell biology international.
[62] B. Spencer‐Dene,et al. Murine but Not Human Mesenchymal Stem Cells Generate Osteosarcoma‐Like Lesions in the Lung , 2007, Stem cells.
[63] P. Collas,et al. Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence , 2007, BMC Cell Biology.
[64] W. Reik. Stability and flexibility of epigenetic gene regulation in mammalian development , 2007, Nature.
[65] Kristian Helin,et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. , 2007, Genes & development.
[66] R. Izadpanah,et al. Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue , 2006, Journal of cellular biochemistry.
[67] G. Semenza,et al. Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. , 2006, Cancer research.
[68] T. Glover,et al. Common fragile sites as targets for chromosome rearrangements. , 2006, DNA repair.
[69] Baojin Fu,et al. Accumulated Chromosomal Instability in Murine Bone Marrow Mesenchymal Stem Cells Leads to Malignant Transformation , 2006, Stem cells.
[70] Ardeshir Ghavamzadeh,et al. BMC Cell Biology BioMed Central Research article Aging of mesenchymal stem cell in vitro , 2005 .
[71] X. Chen,et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells , 2006, Nature Genetics.
[72] Franca Fagioli,et al. Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow , 2006, Journal of cellular biochemistry.
[73] W. Ansorge,et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. , 2005, Experimental hematology.
[74] J. Cigudosa,et al. Spontaneous human adult stem cell transformation. , 2005, Cancer research.
[75] T. Ørntoft,et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis , 2005, Nature.
[76] I. Bellantuono,et al. Study of Telomere Length Reveals Rapid Aging of Human Marrow Stromal Cells following In Vitro Expansion , 2004, Stem cells.
[77] U. Klingmüller,et al. Effects of Telomerase Modulation in Human Hematopoietic Progenitor Cells , 2004, Stem cells.
[78] Christian Clausen,et al. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. , 2003, Bone.
[79] W. Hahn,et al. Telomerase Maintains Telomere Structure in Normal Human Cells , 2003, Cell.
[80] K. Mamchaoui,et al. Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization. , 2003, Molecular cancer research : MCR.
[81] C. Waller,et al. Lack of telomerase activity in human mesenchymal stem cells , 2003, Leukemia.
[82] T. Jensen,et al. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells , 2002, Nature Biotechnology.
[83] C. Harley. Telomerase is not an oncogene , 2002, Oncogene.
[84] E. Blackburn. Switching and Signaling at the Telomere , 2001, Cell.
[85] M. Mastrogiacomo,et al. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. , 2000, Experimental hematology.
[86] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[87] R. G. Allen,et al. Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[88] J. Shay,et al. A survey of telomerase activity in human cancer. , 1997, European journal of cancer.
[89] C Roskelley,et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[90] Carol W. Greider,et al. The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity , 1987, Cell.
[91] L. Hayflick. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. , 1965, Experimental cell research.
[92] P. Andrade,et al. Ex vivo expansion of human mesenchymal stem cells on microcarriers. , 2011, Methods in molecular biology.
[93] P. Collas,et al. Chromatin states of core pluripotency-associated genes in pluripotent, multipotent and differentiated cells. , 2010, Biochemical and biophysical research communications.
[94] D. Huso,et al. Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture. , 2005, Cytotherapy.