The Association of Eosinophilia with Lymphoblastic Leukaemia or Lymphoma: a Study of Seven Patients

Summary Seven patients with hypereosinophilia in association with a lymphoblastic malignancy are described. The eosinophilia preceded or was present at diagnosis in all patients. Eosinophil counts fell during complete remission but rose significantly before or during relapses in five patients. Hypogranular and sometimes Pelgereosinophils were seen in five cases. Surface and enzyme markers defined the malignancy in six cases as common‐ALL (three), T‐ALL (two) and T‐lymphoblastic lymphoma (one). Although a diagnosis of eosinophilic leukaemia or acute myeloid leukaemia with cosinophil differentiation was considered in three patients, cytochemical and ultrastructural studies failed to show any evidence of myeloid differentiation in the blast cells. The bone marrow karyotype was normal in the four patients studied.

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