Performance study of a new time-delay estimation algorithm in ultrasonic echo signals and ultrasound elastography.

Time-delay estimation has countless applications in ultrasound medical imaging. Previously, we proposed a new time-delay estimation algorithm, which was based on the summation of the sign function to compute the time-delay estimate (Shaswary et al., 2015). We reported that the proposed algorithm performs similar to normalized cross-correlation (NCC) and sum squared differences (SSD) algorithms, even though it was significantly more computationally efficient. In this paper, we study the performance of the proposed algorithm using statistical analysis and image quality analysis in ultrasound elastography imaging. Field II simulation software was used for generation of ultrasound radio frequency (RF) echo signals for statistical analysis, and a clinical ultrasound scanner (Sonix® RP scanner, Ultrasonix Medical Corp., Richmond, BC, Canada) was used to scan a commercial ultrasound elastography tissue-mimicking phantom for image quality analysis. The statistical analysis results confirmed that, in overall, the proposed algorithm has similar performance compared to NCC and SSD algorithms. The image quality analysis results indicated that the proposed algorithm produces strain images with marginally higher signal-to-noise and contrast-to-noise ratios compared to NCC and SSD algorithms.