A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
暂无分享,去创建一个
Shijun Zhang | Yuqi Jiang | Dong Sun | Liu He | R. Kuwar | Hongyu Xu | A. Rolfe | Long Di
[1] Jian-ning Zhang,et al. The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury , 2018, Brain Research.
[2] Fei Li,et al. Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury , 2018, Neurobiology of Disease.
[3] C. Beyer,et al. Inflammasome: Its role in traumatic brain and spinal cord injury , 2018, Journal of cellular physiology.
[4] A. Abbate,et al. Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization. , 2018, Journal of medicinal chemistry.
[5] S. Nasoohi,et al. Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke , 2018, Scientific Reports.
[6] S. Nasoohi,et al. MCC950, the selective NLRP3 inflammasome inhibitor protects mice against traumatic brain injury , 2018 .
[7] Y. Kong,et al. Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage , 2018, Stroke.
[8] Yangang Wang,et al. Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1. , 2017, Molecular medicine reports.
[9] A. Bitto,et al. Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury , 2017, Front. Pharmacol..
[10] S. Villapol,et al. Sexual dimorphism in the inflammatory response to traumatic brain injury , 2017, Glia.
[11] Xiaomin Wang,et al. Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury , 2017, Experimental Neurology.
[12] Xiongwei Zhu,et al. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease , 2017, Molecular Neurobiology.
[13] Hülya Bayır,et al. The far-reaching scope of neuroinflammation after traumatic brain injury , 2017, Nature Reviews Neurology.
[14] A. Bitto,et al. BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis. , 2017, Clinical science.
[15] P. Kochanek,et al. Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children , 2017, Neurocritical Care.
[16] P. Kochanek,et al. The far-reaching scope of neuroinflammation after traumatic brain injury , 2017, Nature Reviews Neurology.
[17] J. Lukens,et al. Emerging Roles for the Immune System in Traumatic Brain Injury , 2016, Front. Immunol..
[18] Jianwen Gu,et al. Propofol Inhibits NLRP3 Inflammasome and Attenuates Blast-Induced Traumatic Brain Injury in Rats , 2016, Inflammation.
[19] D. Brough,et al. Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models , 2016, Nature Communications.
[20] T. Williams,et al. Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury , 2016, Mediators of inflammation.
[21] Sally Freeman,et al. Inhibiting the Inflammasome: A Chemical Perspective. , 2016, Journal of medicinal chemistry.
[22] D. Loane,et al. Microglia in the TBI brain: The good, the bad, and the dysregulated , 2016, Experimental Neurology.
[23] D. Butterfield,et al. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. , 2016, Journal of Alzheimer's disease : JAD.
[24] J. Gugenheim,et al. ER stress induces NLRP3 inflammasome activation and hepatocyte death , 2015, Cell Death and Disease.
[25] Anindita Das,et al. Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse , 2015, Journal of cardiovascular pharmacology.
[26] A. Rösen‐Wolff,et al. Caspase-1: an integral regulator of innate immunity , 2015, Seminars in Immunopathology.
[27] K. Schroder,et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases , 2015, Nature Medicine.
[28] Scott W. Rose,et al. A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse , 2014, Journal of cardiovascular pharmacology.
[29] C. Power,et al. Inflammasomes in the CNS , 2014, Nature Reviews Neuroscience.
[30] J. P. de Rivero Vaccari,et al. Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome , 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[31] Simon C Watkins,et al. Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation , 2013, The Journal of Immunology.
[32] C. Hang,et al. Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model , 2013, Neurochemical Research.
[33] G. Núñez,et al. K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. , 2013, Immunity.
[34] L. Tan,et al. The NLRP3 Inflammasome in Alzheimer’s Disease , 2013, Molecular Neurobiology.
[35] K. Schroder,et al. AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC , 2013, Cell Death and Differentiation.
[36] M. Morganti-Kossmann,et al. The Role of Markers of Inflammation in Traumatic Brain Injury , 2013, Front. Neurol..
[37] M. Heneka,et al. NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice , 2012, Nature.
[38] J. P. de Rivero Vaccari,et al. Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome: clinical article. , 2012, Journal of neurosurgery.
[39] R. Germain,et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP , 2012, Nature.
[40] Jiujiu Yu,et al. Critical role for calcium mobilization in activation of the NLRP3 inflammasome , 2012, Proceedings of the National Academy of Sciences.
[41] S. Hammerschmidt,et al. The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release , 2011, The Journal of Immunology.
[42] T. Kielian,et al. Inflammasome activation and IL‐1β/IL‐18 processing are influenced by distinct pathways in microglia , 2011, Journal of neurochemistry.
[43] Dong Sun,et al. Sustained survival and maturation of adult neural stem/progenitor cells after transplantation into the injured brain. , 2011, Journal of neurotrauma.
[44] J. Tschopp,et al. A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.
[45] Denis Gris,et al. The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18 , 2010, The Journal of Neuroscience.
[46] J. Levasseur,et al. Strain-related differences after experimental traumatic brain injury in rats. , 2010, Journal of neurotrauma.
[47] B. Conti,et al. Interleukin 18 in the CNS , 2010, Journal of Neuroinflammation.
[48] V. Dixit,et al. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome , 2009, The Journal of cell biology.
[49] N. Marklund,et al. Neutralization of interleukin‐1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice , 2009, The European journal of neuroscience.
[50] H. Bramlett,et al. Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[51] K. Moore,et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-β , 2008, Nature Immunology.
[52] J. Pickard,et al. Inflammation in Human Brain Injury: Intracerebral Concentrations of IL-1α, IL-1β, and Their Endogenous Inhibitor IL-1ra , 2007 .
[53] J. Pickard,et al. Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. , 2007, Journal of neurotrauma.
[54] N. Rothwell,et al. Interleukin-1 and neuronal injury , 2005, Nature Reviews Immunology.
[55] C. Dinarello,et al. Elevated Intracranial IL-18 in Humans and Mice after Traumatic Brain Injury and Evidence of Neuroprotective Effects of IL-18—Binding Protein after Experimental Closed Head Injury , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[56] W. D. Dietrich,et al. Interleukin-1β Messenger Ribonucleic Acid and Protein Levels after Fluid-Percussion Brain Injury in Rats: Importance of Injury Severity and Brain Temperature. , 2002, Neurosurgery.
[57] G. Stoll,et al. Interleukin-18 Expression after Focal Ischemia of the Rat Brain: Association with the Late-Stage Inflammatory Response , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[58] O. Alonso,et al. Interleukin-1beta messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: importance of injury severity and brain temperature. , 2002, Neurosurgery.
[59] C. Gabel,et al. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. , 2001, The Journal of pharmacology and experimental therapeutics.
[60] G. Stoll,et al. Induction of the proinflammatory cytokine interleukin‐18 by axonal injury , 2001, Journal of neuroscience research.
[61] Katherine J. Griswold,et al. Role of Chemokines, Neuronal Projections, and the Blood‐Brain Barrier in the Enhancement of Cerebral EAE Following Focal Brain Damage , 2000, Journal of Neuropathology and Experimental Neurology.
[62] M. Wadhwa,et al. Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production , 1991, Journal of Neuroimmunology.