Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
暂无分享,去创建一个
[1] G. Carmeliet,et al. The skeletal vascular system - Breathing life into bone tissue. , 2017, Bone.
[2] Klaus Engelke,et al. Effects of Romosozumab Compared With Teriparatide on Bone Density and Mass at the Spine and Hip in Postmenopausal Women With Low Bone Mass , 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[3] P. Carmeliet,et al. Adequate hypoxia inducible factor 1α signaling is indispensable for bone regeneration. , 2016, Bone.
[4] M. Gassmann,et al. Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO‐Producing Cells , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[5] P. Carmeliet,et al. HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival. , 2016, Cell metabolism.
[6] M. Amling,et al. The Anti‐Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5 , 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[7] Marc N. Wein,et al. The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro* , 2015, The Journal of Biological Chemistry.
[8] E. Rankin,et al. Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin , 2015, Genes & development.
[9] Z. Bing,et al. Dimethyloxalylglycine Prevents Bone Loss in Ovariectomized C57BL/6J Mice through Enhanced Angiogenesis and Osteogenesis , 2014, PloS one.
[10] P. Kostenuik,et al. Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats. , 2014, Bone.
[11] Jan Schrooten,et al. Expansion of Murine Periosteal Progenitor Cells with Fibroblast Growth Factor 2 Reveals an Intrinsic Endochondral Ossification Program Mediated by Bone Morphogenetic Protein 2 , 2014, Stem cells.
[12] T. Bellido,et al. The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice. , 2014, Endocrinology.
[13] J. Arbeit,et al. Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation , 2014, Proceedings of the National Academy of Sciences.
[14] R. Adams,et al. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone , 2014, Nature.
[15] Sergei A. Vinogradov,et al. Direct measurement of local oxygen concentration in the bone marrow of live animals , 2014, Nature.
[16] Cesar Libanati,et al. Romosozumab in postmenopausal women with low bone mineral density , 2014, The New England journal of medicine.
[17] T. Martin,et al. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. , 2014, BoneKEy reports.
[18] L. Deng,et al. Prolyl Hydroxylase Inhibitors Protect from the Bone Loss in Ovariectomy Rats by Increasing Bone Vascularity , 2014, Cell Biochemistry and Biophysics.
[19] M. Almeida,et al. The role of estrogen and androgen receptors in bone health and disease , 2013, Nature Reviews Endocrinology.
[20] E. Canalis. Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches , 2013, Nature Reviews Endocrinology.
[21] Sarah L Dallas,et al. The osteocyte: an endocrine cell ... and more. , 2013, Endocrine reviews.
[22] Roland Baron,et al. WNT signaling in bone homeostasis and disease: from human mutations to treatments , 2013, Nature Medicine.
[23] L. Guarente,et al. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin , 2013, EMBO molecular medicine.
[24] J. Kanis,et al. Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[25] Jan Schrooten,et al. Engineering Vascularized Bone: Osteogenic and Proangiogenic Potential of Murine Periosteal Cells , 2012, Stem cells.
[26] G. Loots,et al. Targeted deletion of Sost distal enhancer increases bone formation and bone mass , 2012, Proceedings of the National Academy of Sciences.
[27] M. Ohh,et al. The updated biology of hypoxia‐inducible factor , 2012, The EMBO journal.
[28] J. Schrooten,et al. Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. , 2012, The Journal of clinical investigation.
[29] E. Rankin,et al. The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO , 2012, Cell.
[30] Geert Carmeliet,et al. Hypoxia-driven pathways in bone development, regeneration and disease , 2012, Nature Reviews Rheumatology.
[31] Matthew R Allen,et al. Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. , 2012, Bone.
[32] L. Bonewald,et al. Cell line IDG‐SW3 replicates osteoblast‐to‐late‐osteocyte differentiation in vitro and accelerates bone formation in vivo , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[33] Lynda F. Bonewald,et al. Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway , 2011, PloS one.
[34] R Bogaerts,et al. Development of micro-CT protocols for in vivo follow-up of mouse bone architecture without major radiation side effects. , 2011, Bone.
[35] Kosaku Kurata,et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression , 2011, Nature Medicine.
[36] D. Toiber,et al. Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor. , 2011, Endocrinology.
[37] Jinhu Xiong,et al. Matrix-embedded cells control osteoclast formation , 2011, Nature Medicine.
[38] R. Chen,et al. Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner* , 2011, The Journal of Biological Chemistry.
[39] L. Bonewald,et al. The Amazing Osteocyte , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[40] Ralph Müller,et al. Guidelines for assessment of bone microstructure in rodents using micro–computed tomography , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[41] T. Clemens,et al. Role of HIF‐1α in skeletal development , 2010, Annals of the New York Academy of Sciences.
[42] Y. Mishina,et al. Wnt Inhibitors Dkk1 and Sost Are Downstream Targets of BMP Signaling Through the Type IA Receptor (BMPRIA) in Osteoblasts , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[43] M. Bouxsein,et al. Hypoxia‐inducible factors 1α and 2α exert both distinct and overlapping functions in long bone development , 2010, Journal of cellular biochemistry.
[44] Guoyin Feng,et al. Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β‐Catenin Signaling , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[45] Frederik De Smet,et al. Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization , 2009, Cell.
[46] R. Vennekens,et al. TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. , 2008, Cell metabolism.
[47] P. Kostenuik,et al. Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[48] Matthew R Allen,et al. Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin* , 2008, Journal of Biological Chemistry.
[49] J. Myllyharju. Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets , 2008, Annals of medicine.
[50] Chao Wan,et al. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. , 2007, The Journal of clinical investigation.
[51] L. Bonewald,et al. DMP1-targeted Cre Expression in Odontoblasts and Osteocytes , 2007, Journal of dental research.
[52] R. Jilka,et al. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. , 2005, Endocrinology.
[53] J. Reeve,et al. The FASEB Journal express article 10.1096/fj.05-4221fje. Published online August 25, 2005. ©2005 FASEB , 2022 .
[54] M. Kneissel,et al. SOST is a target gene for PTH in bone. , 2005, Bone.
[55] C. G. Bellows,et al. Effect of simulated weightlessness on osteoprogenitor cell number and proliferation in young and adult rats. , 2005, Bone.
[56] M. Karperien,et al. Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist , 2004, The Journal of experimental medicine.
[57] John A Latham,et al. Osteocyte control of bone formation via sclerostin, a novel BMP antagonist , 2003, The EMBO journal.
[58] P. Ratcliffe,et al. Regulation of angiogenesis by hypoxia: role of the HIF system , 2003, Nature Medicine.
[59] Emily R Morey-Holton,et al. Hindlimb unloading rodent model: technical aspects. , 2002, Journal of applied physiology.
[60] P. Carmeliet,et al. Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 , 2000, Mechanisms of Development.
[61] Yanlei Hao,et al. Hindlimb unloading rodent model : technical aspects , 2002 .
[62] Michael I. Wilson,et al. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.
[63] Toshitaka Nakamura,et al. Trabecular Bone Turnover and Bone Marrow Cell Development in Tail‐Suspended Mice , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[64] D. Lewis,et al. Technical aspects. , 1999, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.
[65] G. Semenza,et al. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. , 1996, The American journal of physiology.
[66] R. Albin. Regeneration , 1993, Neurology.
[67] J. Verhaeghe,et al. Osteocalcin during the reproductive cycle in normal and diabetic rats. , 1989, The Journal of endocrinology.