Vitamin D receptor polymorphism and posttransplantation bone loss

Comments Genetic factors have an important role in bone metabolism. Epidemiological data, including twin studies, leave little doubt that bone mass and osteoporosis are predominantly influenced by genetic factors, with approximately 80% of the variance in bone density genetically determined. 1 The need for prevention of osteoporosis has logically led to an active search for its genetic predictors. The normal allelic variants of several genes are being investigated for their role in the regulation of bone mass. 2 With the importance of vitamin D in calcium homeostasis, the vitamin D receptor (VDR) gene is an obvious candidate gene

[1]  Y. Nakanuma,et al.  Immunohistochemical study on bile ductular proliferation in various hepatobiliary diseases. , 2008, Liver.

[2]  M. Manns,et al.  Tumor necrosis factor α in the pathogenesis of human and murine fulminant hepatic failure , 2000 .

[3]  J. Bruix,et al.  Tumor necrosis factor primes hepatocytes for DNA replication in the rat , 1998, Hepatology.

[4]  A. Demetriou.  Support of the acutely failing liver: state of the art. , 1998, Annals of surgery.

[5]  M. Brandi,et al.  Vitamin D Receptor Genotypes and Intestinal Calcium Absorption in Postmenopausal Women , 1997, Calcified Tissue International.

[6]  B. Portmann,et al.  Auxiliary partial orthotopic liver transplantation for acute liver failure. , 1997, Journal of hepatology.

[7]  Y. Yamaoka,et al.  Coexistence of a graft with the preserved native liver in auxiliary partial orthotopic liver transplantation from a living donor for ornithine transcarbamylase deficiency. , 1997, Transplantation.

[8]  S. Thung,et al.  Characterization of ductular hepatocytes in primary liver allograft failure. , 1997, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[9]  D. Samuel,et al.  Auxiliary partial orthotopic liver transplantation for fulminant hepatitis. The Paul Brousse experience. , 1996, Annals of surgery.

[10]  E. Furth,et al.  Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice , 1996, Science.

[11]  E. Salido,et al.  Influence of vitamin D receptor genotype on bone mass changes after renal transplantation. , 1996, Kidney international.

[12]  C. Christiansen,et al.  Relation of common allelic variation at vitamin D receptor locus to bone mineral density and postmenopausal bone loss: cross sectional and longitudinal population study , 1996, BMJ.

[13]  A. Hofman,et al.  A large‐scale population‐based study of the association of vitamin D receptor gene polymorphisms with bone mineral density , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[14]  R. Purcell,et al.  Hepatitis C virus-associated fulminant hepatic failure. , 1996, The New England journal of medicine.

[15]  L. Byrne.  High conviction rates are seen in child abuse cases , 1996 .

[16]  G. Michalopoulos,et al.  Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes. , 1996, The American journal of pathology.

[17]  Elie,et al.  Auxiliary liver transplantation: Regeneration of the native liver and outcome in 30 patients with fulminant hepatic failure–a multicenter European study , 1996, Hepatology.

[18]  L. Podestá,et al.  Detection of hepatitis C virus with RNA polymerase chain reaction in fulminant hepatic failure , 1995, Hepatology.

[19]  M. Peacock.  Vitamin D receptor gene alleles and osteoporosis: A contrasting view , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  P. Delmas,et al.  Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  B. Dawson-Hughes,et al.  Vitamin D receptor alleles and rates of bone loss: Influences of years since menopause and calcium intake , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[22]  J. Eisman,et al.  The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  T. Spector,et al.  Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain , 1995, BMJ.

[24]  J. Hoofnagle,et al.  Fulminant Hepatic Failure : Summary of a Workshop , 2017 .

[25]  K. Boudjema,et al.  Auxiary Liver Transplantation For Fulminant And Subfulminant Hepatic Failure , 1995 .

[26]  J. Christian,et al.  Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. , 1994, The Journal of clinical investigation.

[27]  J. Eisman,et al.  Prediction of bone density from vitamin D receptor alleles , 1994, Nature.

[28]  J. Lemire,et al.  Cell Lineages in Hepatic Development and the Identification of Progenitor Cells in Normal and Injured Liver , 1993, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[29]  Hay Je.  Bone disease in liver transplant recipients , 1993 .

[30]  S. A. Kucharski.  Fulminant hepatic failure. , 1993, Critical care nursing clinics of North America.

[31]  L. Elmore,et al.  Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan. , 1991, Cancer research.

[32]  M. Moritz,et al.  Heterotopic liver transplantation for fulminant hepatic failure--a bridge to recovery. , 1990, Transplantation.

[33]  S. Sell,et al.  Is there a liver stem cell? , 1990, Cancer research.

[34]  W. Weimar,et al.  Recovery of failing liver after auxiliary heterotopic transplantation , 1990, The Lancet.

[35]  S. Thung.  The development of proliferating ductular structures in liver disease. An immunohistochemical study. , 1990, Archives of pathology & laboratory medicine.

[36]  D. Cole,et al.  Vitamin D-receptor genotypes as independent genetic predictors of decreased bone mineral density in primary biliary cirrhosis. , 2000, Gastroenterology.

[37]  M. G. Peters,et al.  Etiology and outcome for 295 patients with acute liver failure in the United States. , 1999, Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[38]  M. Loda,et al.  Hepatitis C infection: a rare cause of fulminant hepatic failure. , 1995, The American journal of gastroenterology.

[39]  H. Schlitt,et al.  Auxiliary partial orthotopic liver transplantation for acute liver failure: the Hannover experience. , 1994, Clinical transplants.

[40]  J. Hay.  Bone disease in liver transplant recipients. , 1993, Gastroenterology clinics of North America.