The globus pallidus pars interna in goal‐oriented and routine behaviors: Resolving a long‐standing paradox

There is an apparent contradiction between experimental data showing that the basal ganglia are involved in goal‐oriented and routine behaviors and clinical observations. Lesion or disruption by deep brain stimulation of the globus pallidus interna has been used for various therapeutic purposes ranging from the improvement of dystonia to the treatment of Tourette's syndrome. None of these approaches has reported any severe impairment in goal‐oriented or automatic movement.

[1]  Nicolas P. Rougier,et al.  A long journey into reproducible computational neuroscience , 2015, Front. Comput. Neurosci..

[2]  M. Jahanshahi,et al.  Parkinson's Disease, the Subthalamic Nucleus, Inhibition, and Impulsivity , 2015, Movement disorders : official journal of the Movement Disorder Society.

[3]  P. Hedera.  Treatment of Wilson's disease motor complications with deep brain stimulation , 2014, Annals of the New York Academy of Sciences.

[4]  M. Okun,et al.  Surgical Treatment of Dyskinesia in Parkinson’s Disease , 2014, Front. Neurol..

[5]  Y. Loewenstein,et al.  Complex Population Response of Dorsal Putamen Neurons Predicts the Ability to Learn , 2013, PloS one.

[6]  X. Leinekugel,et al.  Why am I lost without dopamine? Effects of 6-OHDA lesion on the encoding of reward and decision process in CA3 , 2013, Neurobiology of Disease.

[7]  T. Boraud,et al.  Interaction between cognitive and motor cortico-basal ganglia loops during decision making: a computational study. , 2013, Journal of neurophysiology.

[8]  B. Bioulac,et al.  Basal Ganglia Preferentially Encode Context Dependent Choice in a Two-Armed Bandit Task , 2011, Front. Syst. Neurosci..

[9]  M. Vidailhet,et al.  Deep brain stimulation for hyperkinetics disorders: dystonia, tardive dyskinesia, and tics. , 2010, Current Opinion in Neurology.

[10]  Michel Desmurget,et al.  Motor Sequences and the Basal Ganglia: Kinematics, Not Habits , 2010, The Journal of Neuroscience.

[11]  B. Day,et al.  What can man do without basal ganglia motor output? The effect of combined unilateral subthalamotomy and pallidotomy in a patient with Parkinson's disease , 2009, Experimental Neurology.

[12]  M. Pessiglione,et al.  Brain Hemispheres Selectively Track the Expected Value of Contralateral Options , 2009, The Journal of Neuroscience.

[13]  John A. Shivik,et al.  Coyotes (Canis latrans) and the matching law , 2009, Behavioural Processes.

[14]  A. Graybiel.  Habits, rituals, and the evaluative brain. , 2008, Annual review of neuroscience.

[15]  P. Glimcher,et al.  Value Representations in the Primate Striatum during Matching Behavior , 2008, Neuron.

[16]  F. Piedimonte,et al.  Pallidal surgery for the treatment of primary generalized dystonia: Long-term follow-up , 2008, Clinical Neurology and Neurosurgery.

[17]  Michael J. Frank,et al.  Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism , 2007, Science.

[18]  K. Doya,et al.  Multiple Representations of Belief States and Action Values in Corticobasal Ganglia Loops , 2007, Annals of the New York Academy of Sciences.

[19]  E. Bézard,et al.  Shaping of Motor Responses by Incentive Values through the Basal Ganglia , 2007, The Journal of Neuroscience.

[20]  E. Vaadia,et al.  Midbrain dopamine neurons encode decisions for future action , 2006, Nature Neuroscience.

[21]  D. Hansel,et al.  Competition between Feedback Loops Underlies Normal and Pathological Dynamics in the Basal Ganglia , 2006, The Journal of Neuroscience.

[22]  P. Dayan,et al.  Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control , 2005, Nature Neuroscience.

[23]  K. Doya,et al.  Representation of Action-Specific Reward Values in the Striatum , 2005, Science.

[24]  E. Miller,et al.  Different time courses of learning-related activity in the prefrontal cortex and striatum , 2005, Nature.

[25]  Barbara J Knowlton,et al.  Analysis of probabilistic classification learning in patients with Parkinson's disease before and after pallidotomy surgery. , 2003, Learning & memory.

[26]  A. Toga,et al.  The Rhesus Monkey Brain in Stereotaxic Coordinates , 1999 .

[27]  O. Hikosaka,et al.  Expectation of reward modulates cognitive signals in the basal ganglia , 1998, Nature Neuroscience.

[28]  T. Robbins,et al.  Bilateral Lesions of the Subthalamic Nucleus Induce Multiple Deficits in an Attentional Task in Rats , 1997, The European journal of neuroscience.

[29]  M. E. Anderson,et al.  Pallidal discharge related to the kinematics of reaching movements in two dimensions. , 1997, Journal of neurophysiology.

[30]  P. Brotchie,et al.  Motor function of the monkey globus pallidus. 2. Cognitive aspects of movement and phasic neuronal activity. , 1991, Brain : a journal of neurology.

[31]  W T Thach,et al.  Basal ganglia motor control. III. Pallidal ablation: normal reaction time, muscle cocontraction, and slow movement. , 1991, Journal of neurophysiology.

[32]  G. E. Alexander,et al.  Preparation for movement: neural representations of intended direction in three motor areas of the monkey. , 1990, Journal of neurophysiology.

[33]  J. Penney,et al.  The functional anatomy of basal ganglia disorders , 1989, Trends in Neurosciences.

[34]  F. Mcsweeney,et al.  Some parameters of behavioral contrast and allocation of interim behavior in rats. , 1985, Journal of the experimental analysis of behavior.

[35]  F. Horak,et al.  Influence of globus pallidus on arm movements in monkeys. I. Effects of kainic acid-induced lesions. , 1984, Journal of neurophysiology.

[36]  W. Temple,et al.  Concurrent schedule assessment of food preference in cows. , 1979, Journal of the experimental analysis of behavior.

[37]  R. O’Reilly,et al.  Separate neural substrates for skill learning and performance in the ventral and dorsal striatum , 2007, Nature Neuroscience.

[38]  T. Vilis,et al.  Arm movement performance during reversible basal ganglia lesions in the monkey , 2004, Experimental Brain Research.

[39]  K. Doya.  Reinforcement Learning in Continuous Time and Space , 2000, Neural Computation.

[40]  G. E. Alexander,et al.  Functional organization of the basal ganglia: contributions of single-cell recording studies. , 1984, Ciba Foundation symposium.

[41]  S. Lea,et al.  OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR THE MATCHING LAW IN AND WITHIN GROUPS OF RATS 1 D , 2005 .

[42]  R J Herrnstein,et al.  Formal properties of the matching law. , 1974, Journal of the experimental analysis of behavior.