论文信息 - Development and validation of spectrofluorimetric method for the estimation of Flupirtine maleate in bulk drug and pharmaceutical dosage form

Development and validation of spectrofluorimetric method for the estimation of Flupirtine maleate in bulk drug and pharmaceutical dosage form

Flupirtine maleate, ethyl (2-amino-6-[(4fluorobenzyl) amino] pyridine-3-yl) carbamate (Figure 1), is an aminopyridine derivative, it used as a centrally acting non-opioid analgesic. Its muscle relaxant properties make it popular for back pain and other orthopaedic uses[1]. Flupirtine also indirectly act as Nmethyl-D-aspartate (NMDA) antagonist[2]. Various methods have been reported for estimation of Flupirtine maleate in bulk and pharmaceutical formulations: the examples of which being. UV SpecUmang Shah*, Mansukh Kavad, Manan Raval Ramanbhai Patel College of Pharmacy, Charotar University of Science & Technology, Changa 388421, Ta.Petlad, Dist.Anand, Gujarat, (INDIA) E-mail: umangshah.ph@ecchanga.ac.in

M. Raval | U. Shah | Ramanbhai B. Patel | M. Kavad

[1] Karthikeyan Kandasamy,et al. Bioanalytical method development, validation and quantification of flupirtine maleate in rat plasma by liquid chromatography-tandem mass spectrometry , 2011, Arzneimittelforschung.

[2] T. P. Aneesh,et al. Method development and validation for estimation of flupirtine maleate in bulk and pharmaceutical dosage forms using UV-Visible Spectrophotometry , 2011 .