TLR signals license CD8 T cells to destroy oligodendrocytes expressing an antigen shared with a Listeria pathogen

Increasing evidence suggests a role of CD8 T cells in autoimmune demyelinating CNS disease, which, however, is still controversially discussed. Mice, which express ovalbumin (OVA) as cytosolic self‐antigen in oligodendrocytes (ODC‐OVA mice), respond to CNS infection induced by OVA‐expressing attenuated Listeria with CD8 T cell‐mediated inflammatory demyelination. This model is suitable to decipher the contribution of CD8 T cells and the pathogen in autoimmune CNS disease.

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