Spirooxindole-pyrrolidine heterocyclic hybrids promotes apoptosis through activation of caspase-3.

[1]  H. Abdel‐Aziz,et al.  Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents , 2017, Journal of enzyme inhibition and medicinal chemistry.

[2]  N. Yusof,et al.  In vivo tumor targeting and anti-tumor effects of 5-fluororacil loaded, folic acid targeted quantum dot system. , 2016, Journal of colloid and interface science.

[3]  H. Al‐Lohedan,et al.  Toxicity assessment of engineered Mn–ZnS quantum dots in vitro , 2016, Journal of Materials Science.

[4]  Dongjun Fu,et al.  Design, Synthesis and Structure-Activity Relationships of Novel Chalcone-1,2,3-triazole-azole Derivates as Antiproliferative Agents , 2016, Molecules.

[5]  Hong-min Liu,et al.  Spirooxindoles: Promising scaffolds for anticancer agents. , 2015, European journal of medicinal chemistry.

[6]  A. Almansour,et al.  A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines , 2015, Molecules.

[7]  C. Kumar,et al.  Targeted hyperthermia-induced cancer cell death by superparamagnetic iron oxide nanoparticles conjugated to luteinizing hormone-releasing hormone , 2014 .

[8]  Liu Liu,et al.  A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. , 2013, Journal of medicinal chemistry.

[9]  Hong-min Liu,et al.  Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole-dithiocarbamate-urea hybrids. , 2013, European journal of medicinal chemistry.

[10]  J. Deschamps,et al.  Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors. , 2013, Journal of the American Chemical Society.

[11]  S. Perumal,et al.  Multi‐Component, 1,3‐Dipolar Cycloaddition Reactions for the Chemo‐, Regio‐ and Stereoselective Synthesis of Novel Hybrid Spiroheterocycles in Ionic Liquid. , 2012 .

[12]  Chun‐Jiang Wang,et al.  Catalytic asymmetric construction of spiro(γ-butyrolactam-γ-butyrolactone) moieties through sequential reactions of cyclic imino esters with Morita-Baylis-Hillman bromides. , 2012, Chemistry.

[13]  Ghodsi Mohammadi Ziarani,et al.  Synthesis of heterocyclic compounds based on isatin through 1,3-dipolar cycloaddition reactions , 2012 .

[14]  P. T. Perumal,et al.  Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity. , 2012, European journal of medicinal chemistry.

[15]  Rebecca SY Wong,et al.  Apoptosis in cancer: from pathogenesis to treatment , 2011, Journal of experimental & clinical cancer research : CR.

[16]  A. Thangamani.  Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+2] cycloaddition of azomethine ylide. , 2010, European journal of medicinal chemistry.

[17]  A. Abbasi,et al.  A facile synthesis of chromeno[3,4-c]spiropyrrolidine-oxindoles via 1,3-dipolar cycloadditions , 2010 .

[18]  B. Conradt.  Genetic control of programmed cell death during animal development. , 2009, Annual review of genetics.

[19]  R. O’Connor,et al.  A review of mechanisms of circumvention and modulation of chemotherapeutic drug resistance. , 2009, Current cancer drug targets.

[20]  K. Scheidt,et al.  Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents. , 2007, Angewandte Chemie.

[21]  S. Elmore.  Apoptosis: A Review of Programmed Cell Death , 2007, Toxicologic pathology.

[22]  H. Pellissier.  Asymmetric 1,3-Dipolar Cycloadditions , 2007 .

[23]  C. Qian,et al.  Basic ionic liquid as catalysis and reaction medium: a novel and green protocol for the Markovnikov addition of N-heterocycles to vinyl esters, using a task-specific ionic liquid, [bmIm]OH. , 2006, The Journal of organic chemistry.

[24]  K. Rück-Braun,et al.  1,3-dipolar cycloaddition on solid supports: nitrone approach towards isoxazolidines and isoxazolines and subsequent transformations. , 2005, Chemical Society reviews.

[25]  E. Carreira,et al.  Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids , 2003 .

[26]  N. Tokitoh,et al.  Asymmetric reduction of nitroalkenes with baker's yeast , 2001 .

[27]  H. Kakeya,et al.  Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties. , 1996, The Journal of antibiotics.