Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer’s Disease Lymphoblast Alterations
暂无分享,去创建一个
C. Pérez | N. Campillo | Á. Martín-Requero | J. A. Páez | F. Bartolomé | M. L. Ceballos | E. Nuñez-Borque | Pedro González-Naranjo | Alejandro Reinares-Sebastián | C. Alquézar
[1] M. L. de Ceballos,et al. Indazolylketones as new multitarget cannabinoid drugs. , 2019, European journal of medicinal chemistry.
[2] Ping Li,et al. Observation of Acetylcholinesterase in Stress-Induced Depression Phenotypes by Two-Photon Fluorescence Imaging in the Mouse Brain. , 2019, Journal of the American Chemical Society.
[3] C. Pérez,et al. Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer’s Disease , 2018, CNS Drugs.
[4] Hongyun Wang,et al. Stimulated CB1 Cannabinoid Receptor Inducing Ischemic Tolerance and Protecting Neuron from Cerebral Ischemia. , 2017, Central nervous system agents in medicinal chemistry.
[5] Maria Vanina Martinez,et al. Hybridizing Feature Selection and Feature Learning Approaches in QSAR Modeling for Drug Discovery , 2017, Scientific Reports.
[6] T. Ulas,et al. A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice , 2017, Nature Medicine.
[7] G. Du,et al. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice , 2017, Molecules.
[8] Jihong Wu,et al. Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons , 2016, Redox biology.
[9] M. Staufenbiel,et al. A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice , 2015, Molecular Neurodegeneration.
[10] J. Molina,et al. G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson’s Disease Patients , 2015, Molecular Neurobiology.
[11] S. Pasquaré,et al. Normal aging in rats and pathological aging in human Alzheimer’s disease decrease FAAH activity: Modulation by cannabinoid agonists , 2014, Experimental Gerontology.
[12] Mohammad A Kamal,et al. Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus. , 2014, CNS & neurological disorders drug targets.
[13] A. Alzualde,et al. PGRN haploinsufficiency increased Wnt5a signaling in peripheral cells from frontotemporal lobar degeneration-progranulin mutation carriers , 2014, Neurobiology of Aging.
[14] I. Ferrer,et al. Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic , 2014, Front. Pharmacol..
[15] M. García-Arencibia,et al. Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease. , 2014, European journal of medicinal chemistry.
[16] F. Bermejo-Pareja,et al. Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer’s disease patients , 2013, Neurobiology of Aging.
[17] C. Pérez,et al. Multitarget cannabinoids as novel strategy for Alzheimer disease. , 2013, Current Alzheimer research.
[18] O. Dı́az-Ruiz,et al. Early post-treatment with 9-cis retinoic acid reduces neurodegeneration of dopaminergic neurons in a rat model of Parkinson’s disease , 2012, BMC Neuroscience.
[19] C. Cotman,et al. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease , 2012, Neurobiology of Aging.
[20] T. Arendt. Cell Cycle Activation and Aneuploid Neurons in Alzheimer's Disease , 2012, Molecular Neurobiology.
[21] P. Chameau,et al. Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors , 2012, Proceedings of the National Academy of Sciences.
[22] Naaheed Mukadam,et al. Systematic review of the effectiveness of non-pharmacological interventions to improve quality of life of people with dementia , 2012, International Psychogeriatrics.
[23] M. Delgado,et al. Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice , 2012, Journal of Neuroinflammation.
[24] A. M. Martín-Moreno,et al. Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease , 2011, Molecular Pharmacology.
[25] Masahiko Watanabe,et al. Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. , 2011, Brain : a journal of neurology.
[26] I. Grundke‐Iqbal,et al. Alzheimer's disease, a multifactorial disorder seeking multitherapies , 2010, Alzheimer's & Dementia.
[27] G. Nikkhah,et al. Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains. , 2009, Current protocols in stem cell biology.
[28] N. Campillo,et al. Cannabinoid system in neurodegeneration: new perspectives in Alzheimer's disease. , 2009, Mini reviews in medicinal chemistry.
[29] Á. Martín-Requero,et al. Enhanced proteasome-dependent degradation of the CDK inhibitor p27kip1 in immortalized lymphocytes from Alzheimer's dementia patients , 2008, Neurobiology of Aging.
[30] Á. Martín-Requero,et al. Impaired apoptosis in lymphoblasts from Alzheimer’s disease patients: Cross-talk of Ca2+/calmodulin and ERK1/2 signaling pathways , 2007, Cellular and Molecular Life Sciences.
[31] A. Makriyannis,et al. Effects of the CB1R agonist WIN-55,212-2 and the CB1R antagonists SR-141716 and AM-1387: Open-field examination in rats , 2006, Pharmacology Biochemistry and Behavior.
[32] G. Uhl,et al. Discovery of the Presence and Functional Expression of Cannabinoid CB2 Receptors in Brain , 2006, Annals of the New York Academy of Sciences.
[33] O. Bachs,et al. The Diverging Roles of Calmodulin and PKC in the Regulation of p21 Intracellular Localization , 2006, Cell cycle.
[34] Rena Li,et al. Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[35] D. Alkon,et al. Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice , 2005, Neurobiology of Aging.
[36] P. Deyn,et al. Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models , 2005, Neurochemistry International.
[37] M. L. de Ceballos,et al. Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation , 2005, The Journal of Neuroscience.
[38] K. Herrup,et al. Divide and Die: Cell Cycle Events as Triggers of Nerve Cell Death , 2004, The Journal of Neuroscience.
[39] R. Weiss. p21Waf1/Cip1 as a therapeutic target in breast and other cancers. , 2003, Cancer cell.
[40] B. Martin,et al. Cannabinoid pharmacological properties common to other centrally acting drugs. , 2003, European journal of pharmacology.
[41] O. Coqueret,et al. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? , 2003, Trends in cell biology.
[42] C. Geula,et al. Neurobiology of butyrylcholinesterase , 2003, Nature Reviews Neuroscience.
[43] C. Masters,et al. Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease , 2002 .
[44] M. Mesulam,et al. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine , 2002, Neuroscience.
[45] M. L. de Ceballos,et al. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. , 2001, Cancer research.
[46] S. Brimijoin,et al. Abundant Tissue Butyrylcholinesterase and Its Possible Function in the Acetylcholinesterase Knockout Mouse , 2000, Journal of neurochemistry.
[47] M. Weinstock,et al. Effect of rivastigmine on scopolamine-induced memory impairment in rats. , 1999, European journal of pharmacology.
[48] D. Ibarreta,et al. Altered Ca2+ homeostasis in lymphoblasts from patients with late-onset Alzheimer disease. , 1997, Alzheimer disease and associated disorders.
[49] C. Geula,et al. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia , 1994, Annals of neurology.
[50] S. Munro,et al. Molecular characterization of a peripheral receptor for cannabinoids , 1993, Nature.
[51] M. Herkenham,et al. Cannabinoid receptor localization in brain. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[52] F. Denizot,et al. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. , 1986, Journal of immunological methods.
[53] N. Campillo,et al. Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's disease and Less Well-Known Diseases. , 2018, Current medicinal chemistry.
[54] P. Wong,et al. Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease , 2003, Nature Medicine.
[55] R. Hampson,et al. Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons , 2003, Hippocampus.
[56] C. Masters,et al. Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. , 2002, Annals of neurology.