Effect of sarcopenia and visceral obesity on mortality and pancreatic fistula following pancreatic cancer surgery

Analytical morphometric assessment has recently been proposed to improve preoperative risk stratification. However, the relationship between body composition and outcomes following pancreaticoduodenectomy is still unclear. The aim of this study was to assess the impact of body composition on outcomes in patients undergoing pancreaticoduodenectomy for cancer.

[1]  N. Demartines,et al.  Classification of Surgical Complications: A New Proposal With Evaluation in a Cohort of 6336 Patients and Results of a Survey , 2004, Annals of Surgery.

[2]  Francesco Carli,et al.  Prehabilitation versus Rehabilitation: A Randomized Control Trial in Patients Undergoing Colorectal Resection for Cancer , 2014, Anesthesiology.

[3]  S. Pocock,et al.  The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies , 2007, The Lancet.

[4]  J. Ijzermans,et al.  Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies , 2015, The British journal of surgery.

[5]  A. Jah,et al.  Scoring System to Predict Pancreatic Fistula After Pancreaticoduodenectomy: A UK Multicenter Study. , 2015, Annals of surgery.

[6]  J. Izbicki,et al.  Preoperative Pancreatic Resection (PREPARE) Score: A Prospective Multicenter-Based Morbidity Risk Score , 2014, Annals of surgery.

[7]  Michael A. Choti,et al.  Impact of Sarcopenia on Outcomes Following Resection of Pancreatic Adenocarcinoma , 2012, Journal of Gastrointestinal Surgery.

[8]  S B Heymsfield,et al.  Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. , 1998, Journal of applied physiology.

[9]  Jae Keun Kim,et al.  The Effect of Visceral Fat Mass on Pancreatic Fistula after Pancreaticoduodenectomy , 2012, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[10]  J. Després,et al.  Abdominal obesity and metabolic syndrome , 2006, Nature.

[11]  H. Yamaue,et al.  Influence of Visceral Obesity for Postoperative Pulmonary Complications After Pancreaticoduodenectomy , 2011, Journal of Gastrointestinal Surgery.

[12]  Abe Fingerhut,et al.  Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition. , 2007, Surgery.

[13]  Tony Reiman,et al.  Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. , 2008, The Lancet. Oncology.

[14]  G. Balzano,et al.  Effect of hospital volume on outcome of pancreaticoduodenectomy in Italy , 2008, The British journal of surgery.

[15]  S. Pocock,et al.  The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. , 2007, Preventive medicine.

[16]  V. Lemmens,et al.  Impact of centralization of pancreatic cancer surgery on resection rates and survival , 2014, The British journal of surgery.

[17]  S. Glantz.  Primer of applied regression and analysis of variance / Stanton A. Glantz, Bryan K. Slinker , 1990 .

[18]  P. Deurenberg,et al.  Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship , 2002, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[19]  Michael A. Choti,et al.  1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience , 2006, Journal of Gastrointestinal Surgery.

[20]  M. Braga,et al.  A Prognostic Score to Predict Major Complications After Pancreaticoduodenectomy , 2011, Annals of surgery.

[21]  Tony Reiman,et al.  A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. , 2008, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[22]  M. Braga,et al.  Enhanced Recovery After Surgery Pathway in Patients Undergoing Pancreaticoduodenectomy , 2014, World Journal of Surgery.

[23]  Stanley Heshka,et al.  Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. , 2004, Journal of applied physiology.

[24]  J. Cameron,et al.  Assessment of Complications After Pancreatic Surgery: A Novel Grading System Applied to 633 Patients Undergoing Pancreaticoduodenectomy , 2006, Annals of surgery.

[25]  T. Osler,et al.  Redesigning surgical decision making for high-risk patients. , 2014, The New England journal of medicine.

[26]  Jeffrey E. Lee,et al.  Ninety-day Postoperative Mortality Is a Legitimate Measure of Hepatopancreatobiliary Surgical Quality , 2015, Annals of surgery.

[27]  Sumithra J. Mandrekar,et al.  Finding Optimal Cutpoints for Continuous Covariates with Binary and Time-to-Event Outcomes , 2006 .

[28]  F. Harrell,et al.  Regression modelling strategies for improved prognostic prediction. , 1984, Statistics in medicine.

[29]  L. Mccargar,et al.  Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[30]  J. Neoptolemos,et al.  Postoperative pancreatic fistula: an international study group (ISGPF) definition. , 2005, Surgery.

[31]  N. Tomita,et al.  A Pancreaticoduodenectomy Risk Model Derived From 8575 Cases From a National Single-Race Population (Japanese) Using a Web-Based Data Entry System: The 30-Day and In-hospital Mortality Rates for Pancreaticoduodenectomy , 2014, Annals of surgery.

[32]  N. Takahashi,et al.  Prediction of Pancreatic Anastomotic Failure After Pancreatoduodenectomy: The Use of Preoperative, Quantitative Computed Tomography to Measure Remnant Pancreatic Volume and Body Composition , 2013, Annals of surgery.

[33]  Zheng Zhou,et al.  Redefining Mortality After Pancreatic Cancer Resection , 2010, Journal of Gastrointestinal Surgery.

[34]  M. Braga,et al.  Effect of Surgeon Volume on Outcome Following Pancreaticoduodenectomy in a High-Volume Hospital , 2012, Journal of Gastrointestinal Surgery.

[35]  W. J. Boscardin,et al.  Functional Status After Colon Cancer Surgery in Elderly Nursing Home Residents , 2012, Journal of the American Geriatrics Society.

[36]  L. Sjöström,et al.  Adipose tissue volume determinations in women by computed tomography: technical considerations. , 1986, International journal of obesity.

[37]  T. Yamanaka,et al.  Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma , 2013, The British journal of surgery.

[38]  W. Uhl,et al.  Pancreatic Surgery in the Very Old: Face to Face With a Challenge of the Near Future , 2013, World Journal of Surgery.

[39]  K. Lassen,et al.  Patient optimization for gastrointestinal cancer surgery , 2013, The British journal of surgery.

[40]  B. Starfield,et al.  Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. , 2002, Archives of internal medicine.

[41]  I. Gögenur,et al.  Core muscle size assessed by perioperative abdominal CT scan is related to mortality, postoperative complications, and hospitalization after major abdominal surgery: a systematic review , 2014, Langenbeck's Archives of Surgery.

[42]  M. Ruiz,et al.  Frailty Syndrome in Geriatric Medicine , 2012, The American journal of the medical sciences.

[43]  Geerard L Beets,et al.  Functional compromise reflected by sarcopenia, frailty, and nutritional depletion predicts adverse postoperative outcome after colorectal cancer surgery. , 2015, Annals of surgery.

[44]  M. Braga,et al.  Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: a randomised multicentre trial , 2001, The Lancet.