论文信息 - Evaluation of hypoglycemic and antihyperglycemic effects of Luffa cylindrica fruit extract in rats

Evaluation of hypoglycemic and antihyperglycemic effects of Luffa cylindrica fruit extract in rats

The present study aimed to assess the hypoglycemic and antihyperglycemic activity of fruit methanolic extract of Luffa cylindrica fruits. The effect of methanolic fruit extract on oral glucose tolerance and its effect on normoglycemic rats were studied. The same was tested for antihyperglycemic activity in alloxan induced hyperglycemic rats at the two dose levels 200 and 400 mg/kg body weight p.o. The serum biochemical parameters were also assessed in the alloxin induced experimental animals. The methanolic extract of Luffa cylindrica exhibited remarkable antihyperglycemic activity. The treatment of diabetic rats with methanolic extract of the test plant improved the serum biochemical parameters and the activities were found to be dose dependent. The present study concludes that Luffa cylindrica fruit extract demonstrated promising antidiabetic activity in alloxan-induced diabetic Wistar rats.

[1] K. D. Tripathi,et al. Essentials of Medical Pharmacology , 2004 .

[2] M. Sabu,et al. Effect of Cassia auriculata Linn. on serum glucose level, glucose utilization by isolated rat hemidiaphragm. , 2002, Journal of ethnopharmacology.

[3] C. Seghers. The Garden , 1999, The Lancet.

[4] M. H. Al-Hakiem,et al. Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. , 1997, Journal of ethnopharmacology.

[5] P. Weidmann,et al. Pathogenesis and treatment of hypertension associated with diabetes mellitus. , 1993, American heart journal.

[6] M. McGrath,et al. GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[7] W. O. HOWARTH,et al. A Text-Book of Pharmacognosy , 1939, Nature.

[8] L. Bailey. The Garden of Gourds , 2019, The Liberty Hyde Bailey Gardener's Companion.

[9] Z. Feng,et al. Improved isolation and further characterization of beta-trichosanthin, a ribosome-inactivating and abortifacient protein from tubers of trichosanthes cucumeroides (cucurbitaceae) , 1991 .

[10] J. Harborne,et al. Phytochemical methods , 1973 .