A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism

[1]  Jean-Claude Némery,et al.  Union européenne , 2018, Statistiques trimestrielles de l'OCDE du commerce international.

[2]  Bung-Nyun Kim,et al.  The effects of GRIN2B and DRD4 gene variants on local functional connectivity in attention-deficit/hyperactivity disorder , 2018, Brain Imaging and Behavior.

[3]  Seung-Soo Baek,et al.  Role of exercise on molecular mechanisms in the regulation of antidepressant effects , 2017, Journal of exercise rehabilitation.

[4]  L. Andersson,et al.  To pace or not to pace: a pilot study of four- and five-gaited Icelandic horses homozygous for the DMRT3 'Gait Keeper' mutation. , 2017, Animal Genetics.

[5]  V. Medici,et al.  Wilson disease: At the crossroads between genetics and epigenetics-A review of the evidence. , 2017, Liver research.

[6]  E. Kuipers,et al.  Analysis of SHIP1 expression and activity in Crohn’s disease patients , 2017, PloS one.

[7]  S. Turvey,et al.  Monogenic immune disorders and severe atopic disease , 2017, Nature Genetics.

[8]  E. Barrey,et al.  Endurance Exercise Ability in the Horse: A Trait with Complex Polygenic Determinism , 2017, Front. Genet..

[9]  L. Andersson,et al.  Lack of significant associations with early career performance suggest no link between the DMRT3 “Gait Keeper” mutation and precocity in Coldblooded trotters , 2017, PloS one.

[10]  J. Sölkner,et al.  Heritability and factors associated with number of harness race starts in the Spanish Trotter horse population , 2017, Equine veterinary journal.

[11]  Winston A Hide,et al.  Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment , 2017, Human molecular genetics.

[12]  Anushya Muruganujan,et al.  PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements , 2016, Nucleic Acids Res..

[13]  Scott J. Myers,et al.  Human GRIN2B variants in neurodevelopmental disorders , 2016, Journal of pharmacological sciences.

[14]  M. Gómez,et al.  Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses. , 2016, Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie.

[15]  Y. Birnbaum,et al.  To Pace or Not to Pace? , 2016, Texas Heart Institute journal.

[16]  R. Polishchuk,et al.  A systems biology approach reveals new endoplasmic reticulum-associated targets for the correction of the ATP7B mutant causing Wilson disease. , 2016, Metallomics : integrated biometal science.

[17]  M. Cragg,et al.  FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells , 2016, The Journal of Immunology.

[18]  E. Bailey,et al.  Comparison of DMRT3 genotypes among American Saddlebred horses with reference to gait. , 2016, Animal genetics.

[19]  H. Kurahashi,et al.  A PDE3A mutation in familial hypertension and brachydactyly syndrome , 2016, Journal of Human Genetics.

[20]  Chaohong Liu,et al.  Novel DOCK8 gene mutations lead to absence of protein expression in patients with hyper-IgE syndrome , 2015, Immunologic Research.

[21]  D. Peden,et al.  Clinically focused exome sequencing identifies an homozygous mutation that confers DOCK8 deficiency , 2016, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[22]  T. Leeb,et al.  Genome-wide association studies based on sequence-derived genotypes reveal new QTL associated with conformation and performance traits in the Franches-Montagnes horse breed. , 2016, Animal genetics.

[23]  M. McCue,et al.  Identification and validation of risk loci for osteochondrosis in standardbreds , 2016, BMC Genomics.

[24]  G. Krystal,et al.  SHIP represses lung inflammation and inhibits mammary tumor metastasis in BALB/c mice , 2015, Oncotarget.

[25]  L. Andersson,et al.  Different DMRT3 Genotypes Are Best Adapted for Harness Racing and Riding in Finnhorses. , 2015, The Journal of heredity.

[26]  C. Clay,et al.  Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. , 2015, Reproduction, fertility, and development.

[27]  Alastair J. Wilson,et al.  Racehorses are getting faster , 2015, Biology Letters.

[28]  L. Andersson,et al.  The importance of the DMRT3 ‘Gait keeper’ mutation on riding traits and gaits in Standardbred and Icelandic horses , 2015 .

[29]  I. Choi,et al.  A Genome-wide Scan for Selective Sweeps in Racing Horses , 2015, Asian-Australasian journal of animal sciences.

[30]  A. Ricard.  Does heterozygosity at the DMRT3 gene make French trotters better racers? , 2015, Genetics Selection Evolution.

[31]  I. Choi,et al.  Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds , 2015, Asian-Australasian journal of animal sciences.

[32]  C. Wade,et al.  Heritability of racing performance in the Australian Thoroughbred racing population. , 2015, Animal genetics.

[33]  J. Petersen,et al.  Haplotype diversity in the equine myostatin gene with focus on variants associated with race distance propensity and muscle fiber type proportions. , 2014, Animal genetics.

[34]  L. Andersson,et al.  Gaitedness is associated with the DMRT3 'Gait keeper' mutation in Morgan and American Curly horses. , 2014, Animal genetics.

[35]  S. Moore,et al.  Speed Index in the Racing Quarter Horse: A Genome-wide Association Study , 2014 .

[36]  L. Andersson,et al.  The DMRT3 'Gait keeper' mutation affects performance of Nordic and Standardbred trotters. , 2014, Journal of animal science.

[37]  Anne-Kathrin Kienzler,et al.  High Levels of SOX5 Decrease Proliferative Capacity of Human B Cells, but Permit Plasmablast Differentiation , 2014, PloS one.

[38]  E. G. Cothran,et al.  Worldwide frequency distribution of the 'Gait keeper' mutation in the DMRT3 gene. , 2014, Animal genetics.

[39]  M. McCue,et al.  Equine developmental orthopaedic diseases--a genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters. , 2013, Animal genetics.

[40]  S. Mohammed,et al.  Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction. , 2013, The Biochemical journal.

[41]  Anushya Muruganujan,et al.  Large-scale gene function analysis with the PANTHER classification system , 2013, Nature Protocols.

[42]  C. Mello,et al.  Genomics analysis of potassium channel genes in songbirds reveals molecular specializations of brain circuits for the maintenance and production of learned vocalizations , 2013, BMC Genomics.

[43]  M. Georges,et al.  Detection of copy number variants in the horse genome and examination of their association with recurrent laryngeal neuropathy. , 2013, Animal genetics.

[44]  Sang Yoon Lee,et al.  Phosphatidylinositol 4-phosphate 5-kinase α negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells , 2013, Experimental & Molecular Medicine.

[45]  G. Apodaca,et al.  PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells , 2013, PloS one.

[46]  E. G. Cothran,et al.  Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds , 2013, PLoS genetics.

[47]  E. Hill,et al.  MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance. , 2012, Animal genetics.

[48]  T. Tozaki,et al.  Heritability estimates for racing performance in Japanese Thoroughbred racehorses using linear and non-linear model analyses. , 2012, Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie.

[49]  M. Ojala,et al.  Genetic parameters for racing records in trotters using linear and generalized linear models. , 2012, Journal of animal science.

[50]  K. Kullander,et al.  Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice , 2012, Nature.

[51]  O. Distl,et al.  A genome-wide association study for quantitative trait loci of show-jumping in Hanoverian warmblood horses. , 2012, Animal genetics.

[52]  T. Árnason,et al.  Validation of alternative models in genetic evaluation of racing performance in North Swedish and Norwegian cold-blooded trotters. , 2012, Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie.

[53]  Stephanie E. Vallee,et al.  Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features , 2012, Human mutation.

[54]  E. Hill,et al.  A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18. , 2012, Animal genetics.

[55]  E. Hill,et al.  Sequence variants at the myostatin gene locus influence the body composition of Thoroughbred horses. , 2011, The Journal of veterinary medical science.

[56]  R. Sacco,et al.  A follow-up study for left ventricular mass on chromosome 12p11 identifies potential candidate genes , 2011, BMC Medical Genetics.

[57]  M. Georges,et al.  Results of a haplotype-based GWAS for recurrent laryngeal neuropathy in the horse , 2011, Mammalian Genome.

[58]  Edwin K Silverman,et al.  SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development. , 2011, American journal of respiratory and critical care medicine.

[59]  M. McCue,et al.  Genome-wide association analysis of osteochondrosis of the tibiotarsal joint in Norwegian Standardbred trotters. , 2010, Animal genetics.

[60]  T. Tozaki,et al.  A genome-wide association study for racing performances in Thoroughbreds clarifies a candidate region near the MSTN gene. , 2010, Animal genetics.

[61]  M. Binns,et al.  Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA. , 2010, Animal genetics.

[62]  E. Hill,et al.  Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance. , 2010, Animal genetics.

[63]  E. Hill,et al.  Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses. , 2010, Equine veterinary journal. Supplement.

[64]  E. Hill,et al.  A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses , 2010, BMC Genomics.

[65]  M. Gómez,et al.  Estimation of genetic parameters for racing speed at different distances in young and adult Spanish Trotter horses using the random regression model. , 2010, Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie.

[66]  Luca Fontanesi,et al.  Analysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types , 2010, Journal of biomedicine & biotechnology.

[67]  N. Orr,et al.  A Sequence Polymorphism in MSTN Predicts Sprinting Ability and Racing Stamina in Thoroughbred Horses , 2010, PloS one.

[68]  M. Mathew,et al.  Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels. , 2010, Biochemical and biophysical research communications.

[69]  Christian Gieger,et al.  Genome-wide association study of PR interval , 2010, Nature Genetics.

[70]  S. Holland,et al.  Combined immunodeficiency associated with DOCK8 mutations. , 2009, The New England journal of medicine.

[71]  A. Thiruvenkadan,et al.  Inheritance of racing performance of trotter horses: An overview , 2009 .

[72]  Brian Everitt,et al.  A Handbook of Statistical Analyses using SAS SECOND EDITION , 2007 .

[73]  Thomas Meitinger,et al.  Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. , 2009, JAMA.

[74]  N. Orr,et al.  A Genome Scan for Positive Selection in Thoroughbred Horses , 2009, PloS one.

[75]  S. Spier,et al.  Evidence for a single pedigree source of the hyperkalemic periodic paralysis susceptibility gene in quarter horses. , 2009, Animal genetics.

[76]  A. Thiruvenkadan,et al.  Inheritance of racing performance of Thoroughbred horses , 2009 .

[77]  S. Powers,et al.  Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. , 2008, Physiological reviews.

[78]  R. Saul,et al.  Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. , 2008, Genomics.

[79]  Joseph Hilbe,et al.  A Handbook of Statistical Analyses Using R , 2006 .

[80]  D. Tilley,et al.  Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease. , 2002, Diabetes.

[81]  J. Weller.  Quantitative Trait Loci Analysis in Animals , 2001 .

[82]  E. Shimizu,et al.  Genetic enhancement of learning and memory in mice , 1999, Nature.

[83]  J. Lübke,et al.  Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. , 1999, Science.

[84]  J. Beech,et al.  Effect of high-intensity exercise on arterial blood gas tensions and upper airway and cardiac function in clinically normal quarter horses and horses heterozygous and homozygous for hyperkalemic periodic paralysis. , 1998, American journal of veterinary research.

[85]  J. Naylor.  Hyperkalemic periodic paralysis. , 1997, The Veterinary clinics of North America. Equine practice.

[86]  J. Naylor,et al.  Hyperkalemic periodic paralysis, plasma lactate and exercise tolerance† , 1996 .

[87]  J. Bertone,et al.  Familial incidence of hyperkalemic periodic paralysis in quarter horses. , 1992, Journal of the American Veterinary Medical Association.

[88]  S. Cannon,et al.  A sodium channel defect in hyperkalemic periodic paralysis: Potassium-induced failure of inactivation , 1991, Neuron.

[89]  P. Grafe,et al.  Adynamia episodica hereditaria: What causes the weakness? , 1989, Muscle & nerve.

[90]  G. Lindgren,et al.  The importance of MSTN for harness racing performance in the Norwegian-Swedish Coldblooded Trotter and the Finnhorse , 2018 .

[91]  G. Gimelli,et al.  Interstitial 9p24.3 deletion involving only DOCK8 and KANK1 genes in two patients with non-overlapping phenotypic traits. , 2016, European journal of medical genetics.

[92]  C. Wade,et al.  Performance selection for Thoroughbreds racing in Hong Kong. , 2015, Equine veterinary journal.

[93]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[94]  D. Misceo,et al.  Post-zygotic breakage of a dicentric chromosome results in mosaicism for a telocentric 9p marker chromosome in a boy with developmental delay. , 2014, Gene.

[95]  E. Hill,et al.  MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses. , 2012, Journal of applied physiology.

[96]  J. Denoix,et al.  Genome-wide association studies for osteochondrosis in French Trotter horses. , 2012, Journal of animal science.

[97]  Mehdi Sargolzaei,et al.  CFC: a tool for monitoring genetic diversity. , 2006 .

[98]  M. Batey.  A handbook of statistical analyses using SPSS. Sabe Landau, Brian S. Everitt, Chapman and Hall/CRC. 2003. £25.99 (pbk) ISBN 1584883693 , 2006 .

[99]  A. Nylander,et al.  Genetic and phenotypic parameters for age at starting to race and racing performance during early career in trotters , 1996 .

[100]  M. Ojala,et al.  Estimates of genetic and phenotypic parameters for racing performance in young trotters , 1991 .

[101]  Edinburgh Research Explorer Genome-wide association analysis identifies multiple loci related to resting heart rate , 2022 .