A genome‐wide study of microsatellite instability in advanced gastric carcinoma

Microsatellite instability (MSI) has been described in many human carcinomas, including gastric carcinomas (GCs). There are inconsistent findings regarding the association of MSI with various subsets of GC with specific clinicopathologic features. The objective of this study was to define MSI in advanced GC at a genome‐wide level and to evaluate the clinical relevance of MSI in these patients.

[1]  D. Shibata,et al.  p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. , 1994, Cancer research.

[2]  J. Gebert,et al.  Microsatellite instability analysis: a multicenter study for reliability and quality control. , 1997, Cancer research.

[3]  M. Mori,et al.  The heterogeneity of microsatellite instability in multiple gastric cancers. , 1995, The American journal of gastroenterology.

[4]  S. Leung,et al.  hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. , 1999, Cancer research.

[5]  D. Sidransky,et al.  Microsatellite instability in bladder cancer. , 1993, Cancer research.

[6]  S Srivastava,et al.  A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. , 1998, Cancer research.

[7]  M. Rhyu,et al.  Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. , 1996, Cancer research.

[8]  G. Tamura,et al.  Microsatellite alterations in adenoma and differentiated adenocarcinoma of the stomach. , 1995, Cancer research.

[9]  M. Slattery,et al.  Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer. , 1995, Gastroenterology.

[10]  P. Quirke,et al.  Microsatellite instability in colorectal cancer: improved assessment using fluorescent polymerase chain reaction. , 1995, Gastroenterology.

[11]  L. Strong,et al.  Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations. , 1996, Oncogene.

[12]  G. Hommel,et al.  Prognostic value and clinicopathological profile of microsatellite instability in gastric cancer. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

[13]  Hsiu‐Po Wang,et al.  Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes , 2000, Genes, chromosomes & cancer.

[14]  W. Park,et al.  Microsatellite instability occurs frequently in human gastric carcinoma. , 1994, Oncogene.

[15]  H. Yamasaki,et al.  Alterations of (CA)n DNA repeats and tumor suppressor genes in human gastric cancer. , 1994, Cancer research.

[16]  M. Fukayama,et al.  Microsatellite instability in the progression of gastric carcinoma. , 1994, Cancer research.

[17]  Darryl Shibata,et al.  Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis , 1993, Nature.

[18]  P. Laurén,et al.  THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. , 1965, Acta pathologica et microbiologica Scandinavica.

[19]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[20]  S. Semba,et al.  Frequent microsatellite instability and loss of heterozygosity in the region including BRCA1 (17q21) in young patients with gastric cancer. , 1998, International journal of oncology.

[21]  J. Sheu,et al.  Infrequent hMSH2 mutations in sporadic gastric adenocarcinoma with microsatellite instability. , 1997, Cancer letters.

[22]  H. Höfler,et al.  Analysis for microsatellite instability and mutations of the DNA mismatch repair gene hMLH1 in familial gastric cancer , 1996, International journal of cancer.

[23]  Y. Nakamura,et al.  Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. , 1993, Cancer research.

[24]  S. Lo,et al.  Results of curative gastrectomy for carcinoma of the distal third of the stomach. , 1996, Journal of the American College of Surgeons.

[25]  J. Weber.  Informativeness of human (dC-dA)n.(dG-dT)n polymorphisms. , 1990, Genomics.

[26]  H. P. Wang,et al.  Clinicopathological significance of altered loci of replication error and microsatellite instability-associated mutations in gastric cancer. , 1998, Cancer research.

[27]  K. Kinzler,et al.  Clues to the pathogenesis of familial colorectal cancer. , 1993, Science.

[28]  R. Seruca,et al.  Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. , 1996, Gastroenterology.

[29]  S N Thibodeau,et al.  Microsatellite instability in cancer of the proximal colon. , 1993, Science.

[30]  P. O'Connell,et al.  Allelic imbalance in gastric cancer: An affected site on chromosome arm 3p , 1995, Genes, chromosomes & cancer.

[31]  仙波 秀峰.  Frequent microsatellite instability and loss of heterozygosity in the region including BRCA1(17q21) in young patients with gastric cancer , 1998 .

[32]  S. Ming.  Gastric carcinoma: A pathobiological classification , 1977 .

[33]  Bert Vogelstein,et al.  Hypermutability and mismatch repair deficiency in RER+ tumor cells , 1993, Cell.

[34]  R. Mariani-Costantini,et al.  Microsatellite instability in gastric cancer is associated with tumor location and family history in a high-risk population from Tuscany. , 1997, Cancer research.

[35]  Cécile Fizames,et al.  The 1993–94 Généthon human genetic linkage map , 1994, Nature Genetics.

[36]  J. Sheu,et al.  Occurrence of microsatellite instability in gastric carcinoma is associated with enhanced expression of erbB-2 oncoprotein. , 1995, Cancer research.

[37]  A. Berchuck,et al.  Genetic instability of microsatellites in endometrial carcinoma. , 1993, Cancer research.

[38]  S. Lo,et al.  Lymph node metastasis from carcinoma of the distal one‐third of the stomach , 1994, Cancer.

[39]  R. Lothe,et al.  Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile , 1995, International journal of cancer.

[40]  S. Baylin,et al.  Frequent microsatellite instability in primary small cell lung cancer. , 1994, Cancer research.

[41]  N. Roodi,et al.  Microsatellite instability and loss of heterozygosity in breast cancer. , 1994, Cancer research.

[42]  H. Inoue,et al.  Microsatellite instability in Japanese gastric cancer , 1995, Cancer.

[43]  E. Hudson,et al.  Advances in Brief Microsatellite Instability Occurs Frequently and in Both Diploid and Aneuploid Cell Populations of Barrett ' s-associated Esophageal Adenocarcinomas ' , 2006 .

[44]  G. Wahl,et al.  Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer. , 1996, Cancer research.