Review article: β3‐adrenoceptor agonists—future anti‐inflammatory drugs for the gastrointestinal tract?

The β3‐adrenoceptor is now a recognized sub‐type of β‐adrenoceptor and is the principle adrenoceptor responsible for lipolysis in rat adipocytes. The receptor is also found in the gastrointestinal tract where β3‐adrenoceptor agonists are both spasmolytic and potent inhibitors of experimental non‐steroidal anti‐inflammatory drug (NSAID)‐induced gastric and small intestinal ulcers. There is evidence to suggest that the underlying mechanism of protection involves enhancement of mucosal blood flow, possibly as a result of relaxation of vascular and non‐vascular smooth muscle.

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